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6 results on '"Georges Herbein"'

1. Sirt1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis

Author

Daniel Wendling, Wasim Abbas, Claire Vidon, Georges Herbein, Eric Toussirot, and Xavier Guillot

Subjects
Adult, biology, business.industry, Sirtuin 1, Anti-Inflammatory Agents, Joint bone, Middle Aged, medicine.disease, Peripheral blood mononuclear cell, Arthritis, Rheumatoid, Rheumatology, Resveratrol, Rheumatoid arthritis, Immunology, Stilbenes, biology.protein, Leukocytes, Mononuclear, Medicine, Humans, business, Interleukin 6, Aged
Abstract

Joint Bone Spine - In Press.Proof corrected by the author Available online since jeudi 17 avril 2014

Published
2014

2. Biological treatments given in patients with rheumatoid arthritis or ankylosing spondylitis modify HAT/HDAC (histone acetyltransferase/histone deacetylase) balance

Author

Eric Toussirot, Daniel Wendling, and Georges Herbein

Subjects
Adult, Ankylosing spondylitis, biology, business.industry, Joint bone, Histone acetyltransferase, Middle Aged, medicine.disease, Histone Deacetylases, Arthritis, Rheumatoid, Biological Therapy, Rheumatology, Rheumatoid arthritis, Cancer research, biology.protein, Medicine, Humans, In patient, Spondylitis, Ankylosing, Histone deacetylase, Epigenetics, business, Aged, Histone Acetyltransferases
Abstract

Joint Bone Spine - In Press.Proof corrected by the author Available online since jeudi 3 avril 2014

Published
2014

3. Targeting intracellular signaling pathways to treat rheumatoid arthritis: Pandora's box?

Author

Clément Prati, Daniel Wendling, Georges Herbein, Eric Toussirot, Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
030203 arthritis & rheumatology, 0303 health sciences, business.industry, Arthritis, medicine.disease, 3. Good health, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Intracellular signaling pathways, Rheumatoid arthritis, Immunology, medicine, Humans, [SDV.IMM]Life Sciences [q-bio]/Immunology, Enzyme Inhibitors, business, ComputingMilieux_MISCELLANEOUS, Signal Transduction, 030304 developmental biology
Abstract

International audience

Published
2010

4. TNFα antagonist therapy in patients with joint disease and chronic viral infection

Author

Georges Herbein, Daniel Wendling, Service de Rhumatologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
Epstein-Barr Virus Infections, Tnfα antagonist, HIV Infections, MESH: Herpesviridae Infections, Viral infection, 03 medical and health sciences, Joint disease, 0302 clinical medicine, Rheumatology, Medicine, In patient, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, MESH: Hepatitis C, 030203 arthritis & rheumatology, 0303 health sciences, MESH: Epstein-Barr Virus Infections, MESH: Hepatitis B, Tumor Necrosis Factor-alpha, business.industry, MESH: Chronic Disease, MESH: HIV Infections, Herpesviridae Infections, Hepatitis B, Hepatitis C, Virology, 3. Good health, MESH: Virus Diseases, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, MESH: Joint Diseases, Virus Diseases, MESH: Tumor Necrosis Factor-alpha, Chronic Disease, Joint Diseases, business
Abstract

International audience

Published
2007

5. Histone deacetylase inhibitors: new treatment options for inflammatory joint disease?

Author

Georges Herbein, Kashif Aziz Khan, Eric Toussirot, Ewa Bertolini, and Daniel Wendling

Subjects
Histone deacetylase 5, HDAC11, business.industry, Histone deacetylase 2, HDAC10, Synovial Membrane, HDAC8, HDAC4, Arthritis, Rheumatoid, Histone Deacetylase Inhibitors, Rheumatology, Cancer research, Medicine, Animals, Humans, Cancer epigenetics, Histone deacetylase, business, Histone Acetyltransferases, Signal Transduction
Abstract

Histone deacetylase inhibitors (HDIs) are a new class of compounds that are being developed for the treatment of malignancies such as cutaneous T-cell lymphoma. HDIs inhibit the removal of acetyl groups from histones. The histone acetylation process is dependent on two enzymes, histone acetyl transferase (HAT) and histone deacetylase (HDAC), and regulates the expression of genes, including those encoding cell survival or apoptosis. In addition to regulating cell growth, HDIs exert anti-inflammatory effects by controlling the production of anti-inflammatory cytokines; modulating the function of cells such as T cells, monocytes-macrophages, chondrocytes, and osteoclasts; and modulating angiogenesis. In several animal models of arthritis, HDIs improve the clinical manifestations and prevent damage to the bone and cartilage. In humans, the only relevant data available so far come from studies of HAT and HDAC expression in the synovial membrane of patients with rheumatoid arthritis. HDIs may hold promise for the treatment of inflammatory joint disease.

Published
2010

6. Sirt1 and osteoarthritis. Comments on the paper by Gabay et al.: 'Sirt1-deficient mice exhibit an altered cartilage phenotype', Joint Bone Spine 2013

Author

Daniel Wendling and Georges Herbein

Subjects
Cartilage, Articular, Pathology, medicine.medical_specialty, biology, business.industry, Sirtuin 1, Cartilage, Joint bone, Osteoarthritis, Anatomy, medicine.disease, Phenotype, Spine (zoology), medicine.anatomical_structure, Rheumatology, biology.protein, Deficient mouse, Animals, Medicine, business
Abstract

Joint Bone Spine - In Press.Proof corrected by the author Available online since samedi 7 decembre 2013

Published
2014

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