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Your search keyword '"Hudis, Clifford"' showing total 11 results
Start Over Author "Hudis, Clifford" Journal jnci: journal of the national cancer institute
11 results on '"Hudis, Clifford"'

1. Serial Analysis of Circulating Tumor Cells in Metastatic Breast Cancer Receiving First-Line Chemotherapy

Author

Magbanua, Mark Jesus M, primary, Hendrix, Laura H, additional, Hyslop, Terry, additional, Barry, William T, additional, Winer, Eric P, additional, Hudis, Clifford, additional, Toppmeyer, Deborah, additional, Carey, Lisa Anne, additional, Partridge, Ann H, additional, Pierga, Jean-Yves, additional, Fehm, Tanja, additional, Vidal-Martínez, José, additional, Mavroudis, Dimitrios, additional, Garcia-Saenz, Jose A, additional, Stebbing, Justin, additional, Gazzaniga, Paola, additional, Manso, Luis, additional, Zamarchi, Rita, additional, Antelo, María Luisa, additional, Mattos-Arruda, Leticia De, additional, Generali, Daniele, additional, Caldas, Carlos, additional, Munzone, Elisabetta, additional, Dirix, Luc, additional, Delson, Amy L, additional, Burstein, Harold J, additional, Qadir, Misbah, additional, Ma, Cynthia, additional, Scott, Janet H, additional, Bidard, François-Clément, additional, Park, John W, additional, and Rugo, Hope S, additional

Published
2020
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2. Serial Analysis of Circulating Tumor Cells in Metastatic Breast Cancer Receiving First-Line Chemotherapy.

Author

Magbanua, Mark Jesus M, Hendrix, Laura H, Hyslop, Terry, Barry, William T, Winer, Eric P, Hudis, Clifford, Toppmeyer, Deborah, Carey, Lisa Anne, Partridge, Ann H, Pierga, Jean-Yves, Fehm, Tanja, Vidal-Martínez, José, Mavroudis, Dimitrios, Garcia-Saenz, Jose A, Stebbing, Justin, Gazzaniga, Paola, Manso, Luis, Zamarchi, Rita, Antelo, María Luisa, and Mattos-Arruda, Leticia De

Subjects
METASTATIC breast cancer, AKAIKE information criterion, CANCER chemotherapy, PROGRESSION-free survival, RESEARCH, RESEARCH evaluation, RESEARCH methodology, METASTASIS, PROGNOSIS, RETROSPECTIVE studies, MEDICAL cooperation, EVALUATION research, TREATMENT effectiveness, COMPARATIVE studies, RESEARCH funding, BREAST tumors, PROPORTIONAL hazards models
Abstract

Background: We examined the prognostic significance of circulating tumor cell (CTC) dynamics during treatment in metastatic breast cancer (MBC) patients receiving first-line chemotherapy.Methods: Serial CTC data from 469 patients (2202 samples) were used to build a novel latent mixture model to identify groups with similar CTC trajectory (tCTC) patterns during the course of treatment. Cox regression was used to estimate hazard ratios for progression-free survival (PFS) and overall survival (OS) in groups based on baseline CTCs, combined CTC status at baseline to the end of cycle 1, and tCTC. Akaike information criterion was used to select the model that best predicted PFS and OS.Results: Latent mixture modeling revealed 4 distinct tCTC patterns: undetectable CTCs (56.9% ), low (23.7%), intermediate (14.5%), or high (4.9%). Patients with low, intermediate, and high tCTC patterns had statistically significant inferior PFS and OS compared with those with undetectable CTCs (P < .001). Akaike Information Criterion indicated that the tCTC model best predicted PFS and OS compared with baseline CTCs and combined CTC status at baseline to the end of cycle 1 models. Validation studies in an independent cohort of 1856 MBC patients confirmed these findings. Further validation using only a single pretreatment CTC measurement confirmed prognostic performance of the tCTC model.Conclusions: We identified 4 novel prognostic groups in MBC based on similarities in tCTC patterns during chemotherapy. Prognostic groups included patients with very poor outcome (intermediate + high CTCs, 19.4%) who could benefit from more effective treatment. Our novel prognostic classification approach may be used for fine-tuning of CTC-based risk stratification strategies to guide future prospective clinical trials in MBC. [ABSTRACT FROM AUTHOR]

Published
2021
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3. Response

Author

Ligibel, Jennifer A., primary, Winer, Eric, additional, Hudis, Clifford A., additional, and Barry, William T., additional

Published
2015
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4. Body Mass Index, PAM50 Subtype, and Outcomes in Node-Positive Breast Cancer: CALGB 9741 (Alliance)

Author

Ligibel, Jennifer A., primary, Cirrincione, Constance T., additional, Liu, Minetta, additional, Citron, Marc, additional, Ingle, James N., additional, Gradishar, William, additional, Martino, Silvana, additional, Sikov, William, additional, Michaelson, Richard, additional, Mardis, Elaine, additional, Perou, Charles M., additional, Ellis, Matthew, additional, Winer, Eric, additional, Hudis, Clifford A., additional, Berry, Donald, additional, and Barry, William T., additional

Published
2015
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5. Maastricht Delphi Consensus on Event Definitions for Classification of Recurrence in Breast Cancer Research

Author

Moossdorff, Martine, primary, van Roozendaal, Lori M., additional, Strobbe, Luc J. A., additional, Aebi, Stefan, additional, Cameron, David A., additional, Dixon, J. Michael, additional, Giuliano, Armando E., additional, Haffty, Bruce G., additional, Hickey, Brigid E., additional, Hudis, Clifford A., additional, Klimberg, V. Suzanne, additional, Koczwara, Bogda, additional, Kühn, Thorsten, additional, Lippman, Marc E., additional, Lucci, Anthony, additional, Piccart, Martine, additional, Smith, Benjamin D., additional, Tjan-Heijnen, Vivianne C. G., additional, van de Velde, Cornelis J. H., additional, Van Zee, Kimberly J., additional, Vermorken, Jan B., additional, Viale, Giuseppe, additional, Voogd, Adri C., additional, Wapnir, Irene L., additional, White, Julia R., additional, and Smidt, Marjolein L., additional

Published
2014
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7. Time to Adjuvant Chemotherapy for Breast Cancer in National Comprehensive Cancer Network Institutions

Author

Vandergrift, Jonathan L., primary, Niland, Joyce C., additional, Theriault, Richard L., additional, Edge, Stephen B., additional, Wong, Yu-Ning, additional, Loftus, Loretta S., additional, Breslin, Tara M., additional, Hudis, Clifford A., additional, Javid, Sara H., additional, Rugo, Hope S., additional, Silver, Samuel M., additional, Lepisto, Eva M., additional, and Weeks, Jane C., additional

Published
2013
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8. Dietary Fat Reduction and Breast Cancer Outcome: Interim Efficacy Results From the Women's Intervention Nutrition Study

Author

Chlebowski, Rowan T., primary, Blackburn, George L., additional, Thomson, Cynthia A., additional, Nixon, Daniel W., additional, Shapiro, Alice, additional, Hoy, M. Katherine, additional, Goodman, Marc T., additional, Giuliano, Armando E., additional, Karanja, Njeri, additional, McAndrew, Philomena, additional, Hudis, Clifford, additional, Butler, John, additional, Merkel, Douglas, additional, Kristal, Alan, additional, Caan, Bette, additional, Michaelson, Richard, additional, Vinciguerra, Vincent, additional, Del Prete, Salvatore, additional, Winkler, Marion, additional, Hall, Rayna, additional, Simon, Michael, additional, Winters, Barbara L., additional, and Elashoff, Robert M., additional

Published
2006
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10. The Taxane Limbo: How Low Can We Go?

Author

Hudis, Clifford and Chau Dang

Subjects
*BREAST cancer, *TUMORS, *DOCETAXEL, *ANTHRACYCLINES, *FLUOROURACIL, *PACLITAXEL
Abstract

The article comments on studies on the use of taxanes to treat breast cancer and other solid tumors, including a study by M. Martin and colleagues on the use of adjuvant docetaxel for node-positive breast cancer. Martin's team compared the effectiveness of an anthracycline-containing regimen against a sequence of fluorouracil, epirubicin and cyclophoshphamide (FEC). The effects of the uses of paclitaxel and docetaxel are also discussed.

Published
2008
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11. Response.

Author

Ligibel, Jennifer A., Winer, Eric, Hudis, Clifford A., and Barry, William T.

Subjects
BODY mass index, BREAST cancer, ANTINEOPLASTIC agents, PROTEIN analysis, BREAST tumors, LYMPH nodes
Abstract

A response by Jennifer A. Ligibel and colleagues to a letter to the editor about their article "Body Mass Index, PAM50 Subtype, and Outcomes in Node-Positive Breast Cancer: CALGB 9741," published in a previous issue is presented.

Published
2016
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