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Thirty-four patients were treated with femtosecond lenticule extraction (FLEx) in 1 eye and small-incision lenticule extraction (SMILE) in the other eye for moderate to high myopia. The procedures were performed using the ReLEx VisuMax femtosecond laser system. Patients were examined before and 6 months after surgery. Overall, the 37 corneal waveform parameters from the Ocular Response Analyzer biomechanical waveform analyzer were not able to detect major differences in corneal biomechanical properties between the flap-based FLEx procedure and the cap-based SMILE procedure.