1. Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study
- Author
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Gülcan Seymen-Karabulut, Ayla Günlemez, Ayşe Sevim Gökalp, Şükrü Hatun, Fatma Kaya Narter, Mehmet Mutlu, Şebnem Kader, Demet Terek, Deniz Hanta, Emel Okulu, Leyla Karadeniz, H. Gözde Kanmaz Kutman, Ayşegül Zenciroğlu, Özmert M. A. Özdemir, Dilek Sarıcı, Muhittin Çelik, Nihat Demir, Özden Turan, Kıymet Çelik, Fatih Kılıçbay, Sinan Uslu, Sara Erol, Sabahattin Ertuğrul, Ilkay Er, Hasan Tolga Çelik, Merih Çetinkaya, Filiz Aktürk-Acar, Yakup Aslan, Gaffari Tunç, Ömer Güran, and Ayşe Engin Arısoy
- Subjects
vitamin d deficiency ,hypocalcemia ,infant ,newborn ,Pediatrics ,RJ1-570 ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Objective:Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D deficiency in LNH in Turkey and to describe the characteristics of affected newborns.Methods:Conducted with a cross-sectional design and with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered on the FAVOR Web Registry System. Serum samples of newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase, intact parathyroid hormone (iPTH) and 25 hydroxyvitamin D [25(OH)D] levels.Results:The median (range) onset time of hypocalcemia was 5.0 (4.0-8.0) days of age, with a male preponderance (60.4%). The median (range) serum 25(OH)D levels of the neonates and their mothers were 6.3 (4.1-9.05) and 5.2 (4.7-8.8) ng/mL, respectively. The prevalence of vitamin D deficiency (
- Published
- 2021
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