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Start Over Author "Okio Hino" Journal japanese journal of pharmacology
6 results on '"Okio Hino"'

2. Hepatoprotective Drugs for the Treatment of Virus-Induced Chronic Hepatitis: From Hypercarcinogenic State to Hypocarcinogenic State

Author

Kazunori Kajino, Okio Hino, and Toshihiro Okamoto

Subjects
Drug, Carcinoma, Hepatocellular, Hepatitis C virus, media_common.quotation_subject, Pharmacology, Protective Agents, medicine.disease_cause, chemistry.chemical_compound, Coumarins, Interferon, medicine, Humans, Glycyrrhizin, media_common, Hepatitis, business.industry, Ribavirin, Standard treatment, Liver Neoplasms, Alanine Transaminase, Hepatitis C, Chronic, Glycyrrhizic Acid, medicine.disease, Liver, chemistry, Hepatocellular carcinoma, Interferons, business, medicine.drug
Abstract

Interferon (IFN)-based therapy is a standard treatment for chronic hepatitis caused by hepatitis C virus (HCV) infection. This treatment is effective in approximately 30-40% of the patients and using ribavirin in combination with IFN increases the rate of sustained virologic clearance. For the remaining patients, glycyrrhizin is often used. Glycyrrhizin is known to prevent the development of hepatocellular carcinoma (HCC), but glycyrrhizin is usually administered intravenously. Drugs that are effective by oral administration are convenient for patients for long-term administration, and development of more effective drugs than glycyrrhizin is preferable. However, studies on drugs for the treatment of hepatitis are not actively conducted, and promotion of the study of drugs in this area is encouraging. For that reason, we show our approach to study drugs for the treatment of hepatitis. We analyzed the effect of glycyrrhizin on hepatitis as a standard chemical using the mouse liver injury model. Based on this, we screened drugs and found that a coumarin derivative seems to be one of model chemicals for the treatment of hepatitis.

Published
2001
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4. Induction of Fas ligand and Fas antigen mRNA expressions in interferon-gamma transgenic mouse liver

Author

Okio Hino, Ken Ichi Yamamura, Tomio Yamakawa, and Toshihiro Okamoto

Subjects
Piecemeal necrosis, Genetically modified mouse, Fas Ligand Protein, CD8 Antigens, Cell, Mice, Transgenic, Hepatitis, Animal, Polymerase Chain Reaction, Fas ligand, Interferon-gamma, Mice, Antigen, Interferon, medicine, Animals, Lymphocytes, RNA, Messenger, fas Receptor, DNA Primers, Pharmacology, Messenger RNA, Membrane Glycoproteins, Chemistry, Histocytochemistry, Tumor Necrosis Factor-alpha, Alanine Transaminase, medicine.disease, Molecular biology, Mice, Inbred C57BL, medicine.anatomical_structure, Gene Expression Regulation, Liver, Infiltration (medical), medicine.drug
Abstract

The interferon-γ (IFN-γ) transgenic mouse develops chronic hepatitis. In the present study, lymphoid cell infiltration and expression of the Fas system were studied in the transgenic mouse liver. Morphological analysis showed the infiltration of lymphoid cells at the portal area and necro-inflammation in the lobules. Furthermore, the infiltrating lymphoid cells were found to be present in the areas of piecemeal necrosis and the intralobular region. The polymerase chain reaction revealed induction of Fas antigen and Fas ligand mRNA expressions. The chronic hepatitis in this mouse reflects the profiles of human chronic hepatitis.

Published
1998

5. Induction of tumor necrosis factor-alpha mRNA in the kidney of the mouse chronic hepatitis model

Author

Tomio Yamakawa, Masami Furuya, Okio Hino, Toshihiro Okamoto, and Ken Ichi Yamamura

Subjects
Genetically modified mouse, Mice, Transgenic, Biology, Kidney, Polymerase Chain Reaction, Interferon-gamma, Mice, Interferon, Gene expression, medicine, Animals, RNA, Messenger, Hepatitis, Chronic, Pharmacology, Messenger RNA, Lung, Tumor Necrosis Factor-alpha, Interleukin, Glyceraldehyde-3-Phosphate Dehydrogenases, Disease Models, Animal, medicine.anatomical_structure, Gene Expression Regulation, Liver, Immunology, Cancer research, Interleukin-2, Tumor necrosis factor alpha, medicine.drug, Interleukin-1
Abstract

Previously we reported the induction of tumor necrosis factor (TNF)-alpha mRNA in the liver of interferon (IFN)-gamma transgenic mouse, which might be the result of IFN-gamma gene expression. In the present study, IFN-gamma mRNA was induced in the liver, kidney and lung. TNF-alpha mRNA was, however, induced in the liver and kidney, but not in the lung. Induction of interleukin (IL)-2 and IL-1beta mRNA was lacking in any of these organs. The present result showed the induction of TNF-alpha mRNA expression in the kidney of transgenic mouse.

Published
1998

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