Search

Your search keyword '"Katsuji Oguchi"' showing total 95 results
Start Over Author "Katsuji Oguchi" Journal japanese journal of pharmacology
95 results on '"Katsuji Oguchi"'

2. Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187-Induced Histamine Release From Rat Peritoneal Exudate Cells

Author

Mayumi Tsuji, Yuko Kanda, Masako Okazaki, Katsuji Oguchi, Yukako Yamazaki, and Shinichi Iwai

Subjects
Male, Iron, Ionophore, chemistry.chemical_element, Calcium, Pharmacology, Alkaline hydrolysis (body disposal), Inhibitory postsynaptic potential, Histamine Release, Rats, Sprague-Dawley, chemistry.chemical_compound, Cromolyn Sodium, Peritoneal exudate, Extracellular, Animals, Anti-Asthmatic Agents, Calcimycin, Microscopy, Confocal, Dose-Response Relationship, Drug, Ionophores, Plant Extracts, Degranulation, Exudates and Transudates, Rats, chemistry, Biochemistry, Peritoneum, Copper, Histamine
Abstract

The effects of Sasa senanensis Rehder extract (SE) by alkaline hydrolysis on histamine release from rat peritoneal exudate cells (PECs) were examined. Preincubation with SE for 5 min suppressed calcium-ionophore A23187-induced histamine release in a concentration-dependent manner. A23187 evoked a quick increase in cytoplasmic free calcium ([Ca2+]i) levels in the presence of extracellular calcium. Preincubation with SE also had an inhibitory effect on calcium influx increases induced by A23187. These results indicate that SE prevents degranulation from rat PECs by inhibiting [Ca2+]i level elevation.

Published
1999
Full Text
View/download PDF

3. Effect of the Centrally Acting Muscle Relaxant Tizanidine on Spinal Reflexes: Involvement of Descending Noradrenergic Systems

Author

Nobutomo Tsuruzoe, Mitsuaki Sakashita, Katsuji Oguchi, Masaki Kitahara, Toyoda Kyomi, and Sadao Nakayama

Subjects
Pharmacology, medicine.medical_specialty, Bile acid, biology, medicine.drug_class, Cholesterol, Reverse cholesterol transport, Metabolism, Cholesterol 7 alpha-hydroxylase, Intestinal absorption, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, HMG-CoA reductase, CYP27A1, medicine, biology.protein, lipids (amino acids, peptides, and proteins)
Abstract

We studied the mechanisms of hypolipidemic effects of NIP-200 (3,5-dimethyl-4,6-diphenyltetrahydro-2H-1,3,5-thiadiazine- 2-thione), a potent hypolipidemic compound, in cholesterol biosynthesis in the liver, cholesterol absorption in small intestine, and cholesterol catabolism and excretion in rats. NIP-200 did not reduce cholesterol biosynthesis and had no effects on cholesterol absorption in the small intestine. In the cholesterol catabolism and excretion, NIP-200 induced increases in cholesterol and bile acids levels in the bile and acidic steroids in the feces, and it enhanced cholesterol 7 alpha-hydroxylase activity in the liver. These results suggest that NIP-200 increases the synthesis of bile acids as a result of the activation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in the conversion of cholesterol to bile acids. Therefore, it is considered that one of the probable mechanisms of the serum total cholesterol lowering action of NIP-200 involves the enhancement of catabolism and excretion of cholesterol in the liver.

Published
1993
Full Text
View/download PDF

4. Sustained Increase in Adrenergic Activity in Gerbil Striatum Following Transient Ischemia

Author

Shino Usami, Katsuji Oguchi, Masahiro Inagaki, Yuji Kiuchi, Yukako Yamazaki, Junkichi Izumi, Daichi Morioka, and Manabu Matsumoto

Subjects
Male, medicine.medical_specialty, Microdialysis, Ischemia, Adrenergic, Biology, Catechol O-Methyltransferase, Gerbil, Brain Ischemia, Norepinephrine (medication), Dopamine, Internal medicine, medicine, Animals, Biogenic Monoamines, Monoamine Oxidase, Pharmacology, Catechol-O-methyl transferase, medicine.disease, Corpus Striatum, Disease Models, Animal, Endocrinology, Reperfusion, Catecholamine, Gerbillinae, medicine.drug
Abstract

We investigated the changes in striatal monoaminergic functions, focusing on the release and metabolism, in a cerebral ischemic model induced by a 5-min bilateral occlusion of the carotid arteries (BOCA) and reperfusion in anesthetized gerbils. In the microdialysis study, the striatal extracellular level of dopamine (DA) markedly increased (144-fold) immediately after BOCA. Although norepinephrine (NE) and 5-hydroxytryptamine (5-HT) could not be detected in the dialysates throughout the baseline period, they increased to detectable levels after BOCA. On the contrary, the tissue contents of NE and 5-HT decreased or tended to decrease up to 4 hr following reperfusion. Striatal DA contents did not show any changes in the early period after ischemia-reperfusion and slightly increased at 4 hr or later. Tissue contents of 3-methoxytyramine (3-MT), a metabolite of DA by catechol-O-methyltransferase (COMT), increased 0 and 5 min after reperfusion. Normethanephrine (NMN), which is a metabolite of NE by COMT, also increased not only 5 min after but also up to 4 hr after ischemia-reperfusion, indicating a sustained increase in NE release. These results suggested that the neuronal activity of NE, which is supposed to exert a protective effect on ischemic damage, was enhanced for a longer period than that of DA after transient ischemia.

Published
1993
Full Text
View/download PDF

8. Changes in Brain Lipid Composition in Thiamine Deficient Rats

Author

Masako Okazaki, Akira Ohtsuki, Hideharu Sakamoto, and Katsuji Oguchi

Subjects
Vitamin, medicine.medical_specialty, medicine.medical_treatment, Intraperitoneal injection, Phospholipid, Biology, Weight Gain, Oxythiamine, chemistry.chemical_compound, Cerebrosides, Internal medicine, medicine, Animals, Phospholipids, Triglycerides, Brain Chemistry, Pharmacology, Triglyceride, Thiamine Deficiency, Rats, Inbred Strains, Lipids, Cerebroside, Rats, Sphingomyelins, Cholesterol, Endocrinology, Pyrithiamine, chemistry, Thiamine, Sphingomyelin, Injections, Intraperitoneal
Abstract

Brain lipid composition was studied in thiamine deficient rats treated with thiamine antimetabolites (oxythiamine: OT, and pyrithiamine: PT) and thiamine deficient diet (TDD). After intraperitoneal injection of OT (40 mg/kg/day) or TDD feeding for 6 days, body weight gain decreased. However, the PT (500 micrograms/kg/day) treated rats or the pair fed control (PFC: TDD + thiamine of 5 mg/kg, i.p.) showed no decrease in body weight gain compared with the regular diet control (C). Brain lipid levels (total lipid, total cholesterol, triglyceride, phospholipid, sphingomyelin and cerebroside) were examined in four brain regions (cerebral cortex, subcortical structure, brain stem and cerebellum). Total lipid level increased in four regions in OT or TDD treated rats, but total lipid level in the cerebellum in PT treated rats decreased. Total cholesterol level increased in all treated rats, while the triglyceride level in the brain stem decreased dramatically in OT or TDD treated rats. Cerebroside levels of four regions in the PT, OT or TDD group remarkably decreased, and PFC rats showed a significant improvement of the decrease in cerebroside level. It is conceivable that these changes in brain lipid composition provided some clues for the histological and morphological changes of the brain as manifested by the myelin degradation in acute thiamine deficiency.

Published
1990
Full Text
View/download PDF

20. Antioxidant activity of tiopronin and bucillamine

Author

Masanori Kashimata, Shichiro Maruyama, Hiroshi Sakagami, Shiro Mita, Kazue Satoh, Katsuji Oguchi, Masahiro Inagaki, and Masamichi Tajima

Subjects
Pharmacology, Antioxidant, Chemistry, medicine.medical_treatment, Bucillamine, Tiopronin, medicine, medicine.drug
Published
1999
Full Text
View/download PDF

47. Effect of low-dose ranitidine on gastric acidity after tetragastrin administration in healthy young volunteers

Author

Akihiko Nagumo, Katsuji Oguchi, Daichi Morioka, Shinichi Kobayashi, Kenji Hamada, Ichiro Fukasawa, Hironori Kato, Haiime Yasuhara, and Eiji Uchida

Subjects
Pharmacology, Ranitidine, medicine.medical_specialty, Gastric acidity, business.industry, Internal medicine, Low dose, medicine, business, Tetragastrin, Gastroenterology, medicine.drug
Published
1993
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results