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Start Over Author "Eikichi Hosoya" Journal japanese journal of pharmacology
33 results on '"Eikichi Hosoya"'

3. Pharmacological effect of Zokumei-to on cerebral ischemia

Author

Atsushi Ishige, Mamoru Suekawa, Eikichi Hosoya, Shuichi Takeda, and Kazuhiro Goto

Subjects
Pharmacology, medicine.medical_specialty, business.industry, Internal medicine, Ischemia, medicine, Cardiology, medicine.disease, business
Published
1990

4. Excellences of Kampo-prescriptions

Author

Eikichi Hosoya

Subjects
Pharmacology, Traditional medicine, business.industry, Kampo, Medicine, Medical prescription, business
Published
1990

8. Effects of Repeated Morphine Administration on Copulation and on the Hypothalamic-Pituitary-Gonadal Axis of Male Rats

Author

Eikichi Hosoya, Takamura Muraki, and Yukiko Tokunaga

Subjects
Male, endocrine system, medicine.medical_specialty, Hypothalamus, Hypothalamic–pituitary–gonadal axis, Genitalia, Male, Gonadotropin-Releasing Hormone, Pregnancy, Internal medicine, Copulation, medicine, Animals, Testosterone, Pharmacology, Diminution, Morphine, business.industry, Body Weight, Seminal Vesicles, Organ Size, Luteinizing Hormone, Sperm, Rats, Endocrinology, Pituitary Gland, Female, business, Luteinizing hormone, medicine.drug, Hormone
Abstract

Adult male rats were administered morphine twice a day for 45 days and the effects of morphine on the copulation rate, the weight of various organs, and on the hypothalamic-pituitary-gonadal axis were examined. Morphine administered rats showed a loss of weight, hypertrophy of the adrenals, decreased weight of accessory sex organs, low sperm count, and decreased copulation rate. The contents of the luteinizing hormone releasing hormone in the hypothalamus and the luteinizing hormone in the pituitary remained unchanged. Serum luteinizing hormone and testosterone levels decreased, but serum follicle-stimulating hormone levels increased. These results suggest that morphine inhibits the hypothalamic-pituitary-gonadal axis and causes a diminution in the number of fertilizations of the partner females.

Published
1977

9. Effect of humoral modulators of morphine-induced increase in locomotor activity of mice

Author

Eikichi Hosoya and Tetsuo Oka

Subjects
Male, medicine.medical_specialty, Physostigmine, Scopolamine, Scopolamine Derivatives, Methyltyrosines, Pharmacology, Adrenergic Neurons, Motor Activity, Mice, Internal medicine, medicine, Animals, Drug Interactions, Mice, Inbred ICR, Tyrosine hydroxylase, Morphine, Chemistry, Fenclonine, Neostigmine, Endocrinology, Cholinergic, Serotonin, Acetylcholine, medicine.drug
Abstract

The effect of humoral modulators on the morphine-induced increase in locomotor activity of mice was studied. The subcutaneous administration of 10 mg/kg of morphine-HC1 produced a marked increase in locomotor activity in mice. The morphine-induced hyperactivity was potentiated by scopolamine and attenuated by physostigmine. In contrast, both methscopolamine and neostigmine, which do not penetrate the blood-brain barrier, had no effect on the hyperactivity produced by morphine. Pretreatment of mice with α-methyltyrosine (20 mg/kg i.p., one hour), an inhibitor of tyrosine hydroxylase, significantly decreased the activity-increasing effects of morphine. On the other hand, pretreatment with p-chlorophenylalamine (3×320 mg/kg i.p., 24 hr), a serotonin depletor, caused no significant change in the hyperactivity. The study suggests that the activity-increasing effects of morphine are mediated by the release of catecholamines from adrenergic neurons in the brain. And the results are consistent with the hypothesis that morphine acts by retarding the release of acetylcholine at some central cholinergic synapses. It is also suggested from collected evidence that the activity-increasing effects of morphine in mice are mediated by mechanisms different from those which mediate the activity-increasing effects of morphine in rats.

Published
1976

14. Protective effects of TJ-960 against pathological changes due to cerebral ischemia

Author

Masaki Aburada, Kazuhiko Sudo, Atsushi Ishige, Eikichi Hosoya, Akira Sugimoto, Susumu Iizuka, Mitsutoshi Yuzurihara, Kyoji Sekiguchi, Kouichi Itoh, and Eiichi Sugaya

Subjects
Pharmacology, Pathology, medicine.medical_specialty, business.industry, medicine, Ischemia, business, medicine.disease, Pathological
Published
1988

15. Radioimmunoassay for methamphetamine [ 1 ]

Author

Eikichi Hosoya, Tetsukichi Niwaguchi, Seiichi Inayama, Yukiko Tokunaga, and Teruo Nakadate

Subjects
Pharmacology, Chromatography, business.industry, Medicine, Radioimmunoassay, Methamphetamine, business, medicine.drug
Published
1977

19. Inhibitory effect of 'TJ-960' on cobalt-induced epilepsy in rats

Author

Atsushi Ishige, Eiichi Sugaya, Susumu Iizuka, Mitsutoshi Yuzurihara, Masaki Aburada, Kyoji Sekiguchi, Akira Sugimoto, Eikichi Hosoya, and Kouichi Itoh

Subjects
Pharmacology, Epilepsy, Chemistry, medicine, chemistry.chemical_element, medicine.disease, Inhibitory effect, Cobalt
Published
1988

21. A new animal behaviour monitoring system

Author

Masaki Aburada, Sumio Minematsu, Yujiro Kobayashi, Yuichi Fujii, and Eikichi Hosoya

Subjects
Pharmacology, Computer science, Systems engineering, Monitoring system
Published
1987

22. Effect of morphine on serum prolactin levels in male rats

Author

Takamura Muraki, Shigenobu Matsumoto, Masako Yasuyama, Eikichi Hosoya, and Yukiko Tokunaga

Subjects
Pharmacology, Serum prolactin, medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Male rats, medicine, Morphine, business, medicine.drug
Published
1977

25. Inhibitory effects of TJ-960 on amygdaloid kindled cats

Author

Kyoji Sekiguchi, Atsushi Ishige, Eiichi Sugaya, Akira Sugimoto, Kouichi Itoh, Eikichi Hosoya, Masaki Aburada, and Susumu Iizuka

Subjects
Pharmacology, CATS, Chemistry, Inhibitory postsynaptic potential
Published
1988

27. Inhibitory effect of 'TJ-960' on cobalt-induced brain edema in rats

Author

Atsushi Ishiqe, Mitsutoshi Yuzurihara, Kyoji Sekiguchi, Susumu Iizuka, Yoko Wakui, Hiromi Sasaki, Kazuhisa Ishihara, Kouichi Itoh, Eikichi Hosoya, Eiichi Sugaya, Shuichi Takeda, and Akira Sugimoto

Subjects
Pharmacology, chemistry, Brain edema, chemistry.chemical_element, Cobalt, Inhibitory effect
Published
1989

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