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Your search keyword '"Granziera, Cristina"' showing total 7 results
Start Over Author "Granziera, Cristina" Journal jama neurology
7 results on '"Granziera, Cristina"'

1. Harmonizing Definitions for Progression Independent of Relapse Activity in Multiple Sclerosis

Author

Müller, Jannis, primary, Cagol, Alessandro, additional, Lorscheider, Johannes, additional, Tsagkas, Charidimos, additional, Benkert, Pascal, additional, Yaldizli, Özgür, additional, Kuhle, Jens, additional, Derfuss, Tobias, additional, Sormani, Maria Pia, additional, Thompson, Alan, additional, Granziera, Cristina, additional, and Kappos, Ludwig, additional

Published
2023
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2. Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination

Author

Ayroza Galvão Ribeiro Gomes, Ana Beatriz, primary, Kulsvehagen, Laila, additional, Lipps, Patrick, additional, Cagol, Alessandro, additional, Cerdá-Fuertes, Nuria, additional, Neziraj, Tradite, additional, Flammer, Julia, additional, Lerner, Jasmine, additional, Lecourt, Anne-Catherine, additional, de Oliveira S. Siebenborn, Nina, additional, Cortese, Rosa, additional, Schaedelin, Sabine, additional, Andreoli Schoeps, Vinicius, additional, de Moura Brasil Matos, Aline, additional, Trombini Mendes, Natalia, additional, dos Reis Pereira, Clarissa, additional, Ribeiro Monteiro, Mario Luiz, additional, dos Apóstolos-Pereira, Samira Luisa, additional, Schindler, Patrick, additional, Chien, Claudia, additional, Schwake, Carolin, additional, Schneider, Ruth, additional, Pakeerathan, Thivya, additional, Aktas, Orhan, additional, Fischer, Urs, additional, Mehling, Matthias, additional, Derfuss, Tobias, additional, Kappos, Ludwig, additional, Ayzenberg, Ilya, additional, Ringelstein, Marius, additional, Paul, Friedemann, additional, Callegaro, Dagoberto, additional, Kuhle, Jens, additional, Papadopoulou, Athina, additional, Granziera, Cristina, additional, and Pröbstel, Anne-Katrin, additional

Published
2023
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3. Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis.

Author

Abdelhak, Ahmed, Benkert, Pascal, Schaedelin, Sabine, Boscardin, W. John, Cordano, Christian, Oechtering, Johanna, Ananth, Kirtana, Granziera, Cristina, Melie-Garcia, Lester, Montes, Shivany Condor, Beaudry-Richard, Alexandra, Achtnichts, Lutz, Oertel, Frederike C., Lalive, Patrice H., Leppert, David, Müller, Stefanie, Henry, Roland G., Pot, Caroline, Matthias, Amandine, and Salmen, Anke

Published
2023
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4. Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis

Author

Meier, Stephanie, primary, Willemse, Eline A.J., additional, Schaedelin, Sabine, additional, Oechtering, Johanna, additional, Lorscheider, Johannes, additional, Melie-Garcia, Lester, additional, Cagol, Alessandro, additional, Barakovic, Muhamed, additional, Galbusera, Riccardo, additional, Subramaniam, Suvitha, additional, Barro, Christian, additional, Abdelhak, Ahmed, additional, Thebault, Simon, additional, Achtnichts, Lutz, additional, Lalive, Patrice, additional, Müller, Stefanie, additional, Pot, Caroline, additional, Salmen, Anke, additional, Disanto, Giulio, additional, Zecca, Chiara, additional, D’Souza, Marcus, additional, Orleth, Annette, additional, Khalil, Michael, additional, Buchmann, Arabella, additional, Du Pasquier, Renaud, additional, Yaldizli, Özgür, additional, Derfuss, Tobias, additional, Berger, Klaus, additional, Hermesdorf, Marco, additional, Wiendl, Heinz, additional, Piehl, Fredrik, additional, Battaglini, Marco, additional, Fischer, Urs, additional, Kappos, Ludwig, additional, Gobbi, Claudio, additional, Granziera, Cristina, additional, Bridel, Claire, additional, Leppert, David, additional, Maleska Maceski, Aleksandra, additional, Benkert, Pascal, additional, and Kuhle, Jens, additional

Published
2023
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5. Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis

Author

Cagol, Alessandro, Cortese, Rosa, Barakovic, Muhamed, Schaedelin, Sabine, Ruberte, Esther, Absinta, Martina, Barkhof, Frederik, Calabrese, Massimiliano, Castellaro, Marco, Ciccarelli, Olga, Cocozza, Sirio, De Stefano, Nicola, Enzinger, Christian, Filippi, Massimo, Jurynczyk, Maciej, Maggi, Pietro, Mahmoudi, Nima, Messina, Silvia, Montalban, Xavier, Palace, Jacqueline, Pontillo, Giuseppe, Pröbstel, Anne-Katrin, Rocca, Maria A., Ropele, Stefan, Rovira, Àlex, Schoonheim, Menno M., Sowa, Piotr, Strijbis, Eva, Wattjes, Mike P., Sormani, Maria Pia, Kappos, Ludwig, and Granziera, Cristina

Abstract

IMPORTANCE: Multiple sclerosis (MS) misdiagnosis remains an important issue in clinical practice. OBJECTIVE: To quantify the performance of cortical lesions (CLs) and central vein sign (CVS) in distinguishing MS from other conditions showing brain lesions on magnetic resonance imaging (MRI). DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective, cross-sectional multicenter study, with clinical and MRI data acquired between January 2010 and May 2020. Centralized MRI analysis was conducted between July 2020 and December 2022 by 2 raters blinded to participants’ diagnosis. Participants were recruited from 14 European centers and from a multicenter pan-European cohort. Eligible participants had a diagnosis of MS, clinically isolated syndrome (CIS), or non-MS conditions; availability of a brain 3-T MRI scan with at least 1 sequence suitable for CL and CVS assessment; presence of T2-hyperintense white matter lesions (WMLs). A total of 1051 individuals were included with either MS/CIS (n = 599; 386 [64.4%] female; mean [SD] age, 41.5 [12.3] years) or non-MS conditions (including other neuroinflammatory disorders, cerebrovascular disease, migraine, and incidental WMLs in healthy control individuals; n = 452; 302 [66.8%] female; mean [SD] age, 49.2 [14.5] years). Five individuals were excluded due to missing clinical or demographic information (n = 3) or unclear diagnosis (n = 2). EXPOSURES: MS/CIS vs non-MS conditions. MAIN OUTCOMES AND MEASURES: Area under the receiver operating characteristic curves (AUCs) were used to explore the diagnostic performance of CLs and the CVS in isolation and in combination; sensitivity, specificity, and accuracy were calculated for various cutoffs. The diagnostic importance of CLs and CVS compared to conventional MRI features (ie, presence of infratentorial, periventricular, and juxtacortical WMLs) was ranked with a random forest model. RESULTS: The presence of CLs and the previously proposed 40% CVS rule had a sensitivity, specificity, and accuracy for MS of 59.0% (95% CI, 55.1-62.8), 93.6% (95% CI, 91.4-95.6), and 73.9% (95% CI, 71.6-76.3) and 78.7% (95% CI, 75.5-82.0), 86.0% (95% CI, 82.1-89.5), and 81.5% (95% CI, 78.9-83.7), respectively. The diagnostic performance of the CVS (AUC, 0.89 [95% CI, 0.86-0.91]) was superior to that of CLs (AUC, 0.77 [95% CI, 0.75-0.80]; P < .001), and was increased when combining the 2 imaging markers (AUC, 0.92 [95% CI, 0.90-0.94]; P = .04); in the random forest model, both CVS and CLs outperformed the presence of infratentorial, periventricular, and juxtacortical WMLs in supporting MS differential diagnosis. CONCLUSIONS AND RELEVANCE: The findings in this study suggest that CVS and CLs may be valuable tools to increase the accuracy of MS diagnosis.

Published
2024
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7. Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis

Author

Cagol, Alessandro, primary, Schaedelin, Sabine, additional, Barakovic, Muhamed, additional, Benkert, Pascal, additional, Todea, Ramona-Alexandra, additional, Rahmanzadeh, Reza, additional, Galbusera, Riccardo, additional, Lu, Po-Jui, additional, Weigel, Matthias, additional, Melie-Garcia, Lester, additional, Ruberte, Esther, additional, Siebenborn, Nina, additional, Battaglini, Marco, additional, Radue, Ernst-Wilhelm, additional, Yaldizli, Özgür, additional, Oechtering, Johanna, additional, Sinnecker, Tim, additional, Lorscheider, Johannes, additional, Fischer-Barnicol, Bettina, additional, Müller, Stefanie, additional, Achtnichts, Lutz, additional, Vehoff, Jochen, additional, Disanto, Giulio, additional, Findling, Oliver, additional, Chan, Andrew, additional, Salmen, Anke, additional, Pot, Caroline, additional, Bridel, Claire, additional, Zecca, Chiara, additional, Derfuss, Tobias, additional, Lieb, Johanna M., additional, Remonda, Luca, additional, Wagner, Franca, additional, Vargas, Maria I., additional, Du Pasquier, Renaud, additional, Lalive, Patrice H., additional, Pravatà, Emanuele, additional, Weber, Johannes, additional, Cattin, Philippe C., additional, Gobbi, Claudio, additional, Leppert, David, additional, Kappos, Ludwig, additional, Kuhle, Jens, additional, and Granziera, Cristina, additional

Published
2022
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