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Your search keyword '"Chavarro, Jorge E."' showing total 17 results
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17 results on '"Chavarro, Jorge E."'

3. Menstrual Cycle Regularity and Length Across the Reproductive Lifespan and Risk of Cardiovascular Disease

Author

Wang, Yi-Xin, primary, Stuart, Jennifer J., additional, Rich-Edwards, Janet W., additional, Missmer, Stacey A., additional, Rexrode, Kathryn M., additional, Farland, Leslie V., additional, Mukamal, Kenneth J., additional, Nelson, Scott M., additional, Solomon, Caren G., additional, Fraser, Abigail, additional, and Chavarro, Jorge E., additional

Published
2022
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6. Association of Habitual Alcohol Consumption With Long-term Risk of Type 2 Diabetes Among Women With a History of Gestational Diabetes

Author

Hinkle, Stefanie N., primary, Bao, Wei, additional, Wu, Jing, additional, Sun, Yangbo, additional, Ley, Sylvia H., additional, Tobias, Deirdre K., additional, Qian, Frank, additional, Rawal, Shristi, additional, Zhu, Yeyi, additional, Chavarro, Jorge E., additional, Hu, Frank B., additional, and Zhang, Cuilin, additional

Published
2021
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16. Association of Birth Weight With Type 2 Diabetes and Glycemic Traits

Author

Huang, Tao, Wang, Tiange, Zheng, Yan, Ellervik, Christina, Li, Xiang, Gao, Meng, Fang, Zhe, Chai, Jin-Fang, Ahluwalia, Tarun veer S., Wang, Yujie, Voortman, Trudy, Noordam, Raymond, Frazier-Wood, Alexis, Scholz, Markus, Sonestedt, Emily, Akiyama, Masato, Dorajoo, Rajkumar, Zhou, Ang, Kilpeläinen, Tuomas O., Kleber, Marcus E., Crozier, Sarah R., Godfrey, Keith M., Lemaitre, Rozenn, Felix, Janine F., Shi, Yuan, Gupta, Preeti, Khor, Chiea-Chuen, Lehtimäki, Terho, Wang, Carol A., Tiesler, Carla M. T., Thiering, Elisabeth, Standl, Marie, Rzehak, Peter, Marouli, Eirini, He, Meian, Lecoeur, Cécile, Corella, Dolores, Lai, Chao-Qiang, Moreno, Luis A., Pitkänen, Niina, Boreham, Colin A., Zhang, Tao, Saw, Seang Mei, Ridker, Paul M., Graff, Mariaelisa, van Rooij, Frank J. A., Uitterlinden, Andre G., Hofman, Albert, van Heemst, Diana, Rosendaal, Frits R., de Mutsert, Renée, Burkhardt, Ralph, Schulz, Christina-Alexandra, Ericson, Ulrika, Kamatani, Yoichiro, Yuan, Jian-Min, Power, Chris, Hansen, Torben, Sørensen, Thorkild I. A., Tjønneland, Anne, Overvad, Kim, Delgado, Graciela, Cooper, Cyrus, Djousse, Luc, Rivadeneira, Fernando, Jameson, Karen, Zhao, Wanting, Liu, Jianjun, Lee, Nanette R., Raitakari, Olli, Kähönen, Mika, Viikari, Jorma, Grote, Veit, Langhendries, Jean-Paul, Koletzko, Berthold, Escribano, Joaquin, Verduci, Elvira, Dedoussis, George, Yu, Caizheng, Tham, Yih Chung, Lim, Blanche, Lim, Sing Hui, Froguel, Philippe, Balkau, Beverley, Fink, Nadia R., Vinding, Rebecca K., Sevelsted, Astrid, Bisgaard, Hans, Coltell, Oscar, Dallongeville, Jean, Gottrand, Frédéric, Pahkala, Katja, Niinikoski, Harri, Hyppönen, Elina, Pedersen, Oluf, März, Winfried, Inskip, Hazel, Jaddoe, Vincent W. V., Dennison, Elaine, Wong, Tien Yin, Sabanayagam, Charumathi, Tai, E-Shyong, Mohlke, Karen L., Mackey, David A., Gruszfeld, Dariusz, Deloukas, Panagiotis, Tucker, Katherine L., Fumeron, Frédéric, Bønnelykke, Klaus, Rossing, Peter, Estruch, Ramon, Ordovas, Jose M., Arnett, Donna K., Meirhaeghe, Aline, Amouyel, Philippe, Cheng, Ching-Yu, Sim, Xueling, Teo, Yik Ying, van Dam, Rob M., Koh, Woon-Puay, Orho-Melander, Marju, Loeffler, Markus, Kubo, Michiaki, Thiery, Joachim, Mook-Kanamori, Dennis O., Mozaffarian, Dariush, Psaty, Bruce M., Franco, Oscar H., Wu, Tangchun, North, Kari E., Davey Smith, George, Chavarro, Jorge E., Chasman, Daniel I., and Qi, Lu

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17. Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.

Author

Huang T, Wang T, Zheng Y, Ellervik C, Li X, Gao M, Fang Z, Chai JF, Ahluwalia TVS, Wang Y, Voortman T, Noordam R, Frazier-Wood A, Scholz M, Sonestedt E, Akiyama M, Dorajoo R, Zhou A, Kilpeläinen TO, Kleber ME, Crozier SR, Godfrey KM, Lemaitre R, Felix JF, Shi Y, Gupta P, Khor CC, Lehtimäki T, Wang CA, Tiesler CMT, Thiering E, Standl M, Rzehak P, Marouli E, He M, Lecoeur C, Corella D, Lai CQ, Moreno LA, Pitkänen N, Boreham CA, Zhang T, Saw SM, Ridker PM, Graff M, van Rooij FJA, Uitterlinden AG, Hofman A, van Heemst D, Rosendaal FR, de Mutsert R, Burkhardt R, Schulz CA, Ericson U, Kamatani Y, Yuan JM, Power C, Hansen T, Sørensen TIA, Tjønneland A, Overvad K, Delgado G, Cooper C, Djousse L, Rivadeneira F, Jameson K, Zhao W, Liu J, Lee NR, Raitakari O, Kähönen M, Viikari J, Grote V, Langhendries JP, Koletzko B, Escribano J, Verduci E, Dedoussis G, Yu C, Tham YC, Lim B, Lim SH, Froguel P, Balkau B, Fink NR, Vinding RK, Sevelsted A, Bisgaard H, Coltell O, Dallongeville J, Gottrand F, Pahkala K, Niinikoski H, Hyppönen E, Pedersen O, März W, Inskip H, Jaddoe VWV, Dennison E, Wong TY, Sabanayagam C, Tai ES, Mohlke KL, Mackey DA, Gruszfeld D, Deloukas P, Tucker KL, Fumeron F, Bønnelykke K, Rossing P, Estruch R, Ordovas JM, Arnett DK, Meirhaeghe A, Amouyel P, Cheng CY, Sim X, Teo YY, van Dam RM, Koh WP, Orho-Melander M, Loeffler M, Kubo M, Thiery J, Mook-Kanamori DO, Mozaffarian D, Psaty BM, Franco OH, Wu T, North KE, Davey Smith G, Chavarro JE, Chasman DI, and Qi L

Subjects
Adolescent, Adult, Aged, Asian People genetics, Blood Glucose metabolism, Diabetes Mellitus, Type 2 genetics, Asia, Eastern, Female, Genetic Variation, Glycated Hemoglobin metabolism, Humans, Infant, Newborn, Insulin metabolism, Male, Mendelian Randomization Analysis, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, White People genetics, Young Adult, Birth Weight genetics, Diabetes Mellitus, Type 2 epidemiology
Abstract

Importance: Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations., Objective: To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis., Design, Setting, and Participants: This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleotide polymorphisms. The associations of this score with birth weight and T2D were tested in a mendelian randomization analysis using study-level data. The association of birth weight with T2D was tested using both study-level data (7 single-nucleotide polymorphisms were used as an instrumental variable) and summary-level data from the consortia (43 single-nucleotide polymorphisms were used as an instrumental variable). Data from 180 056 participants from 49 studies were included., Main Outcomes and Measures: Type 2 diabetes and glycemic traits., Results: This mendelian randomization analysis included 49 studies with 41 155 patients with T2D and 80 008 control participants from study-level data and 34 840 patients with T2D and 114 981 control participants from summary-level data. Study-level data showed that a 1-SD decrease in birth weight due to the genetic risk score was associated with higher risk of T2D among all participants (odds ratio [OR], 2.10; 95% CI, 1.69-2.61; P = 4.03 × 10-5), among European participants (OR, 1.96; 95% CI, 1.42-2.71; P = .04), and among East Asian participants (OR, 1.39; 95% CI, 1.18-1.62; P = .04). Similar results were observed from summary-level analyses. In addition, each 1-SD lower birth weight was associated with 0.189 SD higher fasting glucose concentration (β = 0.189; SE = 0.060; P = .002), but not with fasting insulin, 2-hour glucose, or hemoglobin A1c concentration., Conclusions and Relevance: In this study, a genetic predisposition to lower birth weight was associated with increased risk of T2D and higher fasting glucose concentration, suggesting genetic effects on retarded fetal growth and increased diabetes risk that either are independent of each other or operate through alterations of integrated biological mechanisms.

Published
2019
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