1. Association of Time Between Left Ventricular and Aortic Systolic Pressure Peaks With Severity of Aortic Stenosis and Calcification of Aortic Valve
- Author
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Robin George, Yash Jobanputra, Amar Krishnaswamy, Wael A. Jaber, Jorge Betancor, E. Murat Tuzcu, Mohamed Halane, Samir R. Kapadia, Serge C. Harb, Vivek Menon, Kimi Sato, Stephanie Mick, Lars G. Svensson, and Arnav Kumar
- Subjects
Aortic valve ,Male ,medicine.medical_specialty ,Cardiac Catheterization ,medicine.medical_treatment ,Heart Ventricles ,Blood Pressure ,030204 cardiovascular system & hematology ,Severity of Illness Index ,Ventricular Function, Left ,Transcatheter Aortic Valve Replacement ,03 medical and health sciences ,0302 clinical medicine ,Valve replacement ,medicine.artery ,Internal medicine ,Multidetector Computed Tomography ,medicine ,Humans ,Arterial Pressure ,030212 general & internal medicine ,Cardiac catheterization ,Aged ,Aged, 80 and over ,Aorta ,business.industry ,Hemodynamics ,Calcinosis ,Aortic Valve Stenosis ,medicine.disease ,Stenosis ,Blood pressure ,medicine.anatomical_structure ,Logistic Models ,Echocardiography ,Aortic valve stenosis ,Aortic Valve ,Multivariate Analysis ,Cardiology ,Female ,Aortic valve calcification ,Cardiology and Cardiovascular Medicine ,business - Abstract
Diagnosis of low-gradient severe aortic stenosis (AS) is challenging. We hypothesized that the time between left ventricular (LV) and aortic systolic pressure peaks (TLV-Ao) is associated with aortic stenosis (AS) severity and may have additive value in diagnosing severe AS, especially in patients with low-gradient AS.To investigate the diagnostic utility of measuring catheter-based TLV-Ao in patients with severe AS.We studied 123 patients with severe AS at the Cleveland Clinic Foundation, a tertiary referral center, who underwent transcatheter aortic valve replacement (TAVR) via femoral access and had pre-TAVR cardiac computed tomography assessment and hemodynamic measurements recorded during a TAVR procedure. All patients received hemodynamic evaluation, echocardiographic assessment, and quantification of aortic valve calcification (AVC) by multidetector computed tomography. Hemodynamic data were collected via left heart catheterization done just before TAVR, and TLV-Ao was calculated offline. Data were analyzed between October 5, 2015, and July 20, 2016.The association between TLV-Ao and AVC or other conventional imaging parameters was analyzed.Of the included patients, the mean (SD) age was 81 (9) years, and 65 (54%) were men (54%). Among 123 patients, 48 patients (39%) had low-gradient AS (40 mm Hg) and mean (SD) TLV-Ao was 69 (39) milliseconds. In multivariable logistic regression analyses, higher TLV-Ao (odds ratio [OR], 1.02; 95% CI, 1.01-1.04; P = .002) and higher peak aortic valve (AV) velocity (OR, 1.01; 95% CI, 1.00-1.02; P = .008) were independently associated with severe AVC (AVC1000 AU). Adding TLV-Ao to the peak AV velocity and AV area showed significant incremental value to be associated with AVC, with a net reclassification improvement of 0.61 (95% CI, 0.23-0.99; P = .002) and integrated discriminatory improvement of 0.09 (95% CI, 0.03-0.16; P = .003). In a subgroup of patients with low-grade AS, higher TLV-Ao was the only parameter associated with severe AVC (OR, 1.02; 95% CI, 1.001-1.04; P = .03).Prolonged TLV-Ao was associated with severe AVC. This catheter-based hemodynamic index may be an additional surrogate to differentiate low-gradient true severe AS. Larger, prospective studies investigating the role of TLV-Ao as a marker of clinical outcomes in patients undergoing TAVR are required.
- Published
- 2019