1. Fatal massive hepatic necrosis following acetaminophen overdose.
- Author
-
McJunkin B, Barwick KW, Little WC, and Winfield JB
- Subjects
- Adult, Autopsy, Female, Humans, Kidney pathology, Kidney Tubular Necrosis, Acute chemically induced, Liver pathology, Liver Diseases complications, Necrosis, Acetaminophen poisoning, Chemical and Drug Induced Liver Injury
- Abstract
A young woman ingested approximately 13 gm of an over-the-counter acetaminophen preparation and died seven days later in profound coma. Postmortem findings included massive centrilobular hepatic necrosis and renal tubular necrosis. Although hepatotoxicity secondary to acetaminophen overdose is well recognized in Britain, this entity has received little emphasis in the United States. Recognition of the potentially severe consequences is important because early treatment with sulfhydryl compounds may prevent serious liver injury.
- Published
- 1976