1. Prostatic acid phosphatase by radioimmunoassay. Sensitivity compared with enzymatic assay.
- Author
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Lindholm GR, Stirton S, Liedtke RJ, and Batjer JD
- Subjects
- Humans, Male, Neoplasm Staging, Prostatic Hyperplasia diagnosis, Prostatic Neoplasms pathology, Acid Phosphatase metabolism, Clinical Enzyme Tests, Prostate enzymology, Prostatic Neoplasms diagnosis, Radioimmunoassay
- Abstract
Prostatic acid phosphatase values in 98 patients with prostatic carcinoma were measured by a commercial radioimmunoassay (RIA) and by enzymatic assay. Forty-three carcinomas were staged by rigorous pathological criteria. Patients (N = 129) with benign prostatic hyperplasia were the control group. At 94% specificity, sensitivities of the RIA vs the enzymatic assay for clinically staged patients were as follows: stage A, 22% vs 6%; B, 29% vs 10%; C, 52% vs 38%; and D, 87% vs 80%. However, none of the seven patients with pathological stage A and B disease had a positive test result, and we suggest that variability in staging criteria accounts for the discrepant sensitivity claims reported. Prostatic acid phosphatase RIA should not be used for screening but as an adjunct for staging known prostatic carcinoma.
- Published
- 1980