1. Effect of Sustained Smoking Cessation Counseling and Provision of Medication vs Shorter-term Counseling and Medication Advice on Smoking Abstinence in Patients Recently Diagnosed With Cancer
- Author
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Irina Gonzalez, Colin Ponzani, Kelly A. Hyland, Nancy A. Rigotti, Alona Muzikansky, Mary E. Cooley, Giselle K. Perez, Douglas E. Levy, Kim Sprunck, Jamie S. Ostroff, Kelly E. Irwin, Emily Friedman, Diana Kwon, Jacob Miller-Sobel, Sarah P. Borderud, Suhana de León-Sanchez, Lisa Peterson, C. Will Whitlock, Julia Rabin, Maureen O'Brien, Laura Malloy, Susan Regan, Ann H. Partridge, Elyse R. Park, Jennifer S. Temel, Susan Holland, and William F. Pirl
- Subjects
Counseling ,Male ,Temperance ,medicine.medical_treatment ,Health Behavior ,Motivational interviewing ,01 natural sciences ,law.invention ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Neoplasms ,030212 general & internal medicine ,Cotinine ,Varenicline ,Original Investigation ,media_common ,Smoking Cessation Agents ,Standard treatment ,Smoking ,General Medicine ,Middle Aged ,Tobacco Use Cessation Devices ,Patient Satisfaction ,Female ,medicine.medical_specialty ,media_common.quotation_subject ,Motivational Interviewing ,Decision Support Techniques ,03 medical and health sciences ,Telephone counseling ,Internal medicine ,medicine ,Humans ,0101 mathematics ,Saliva ,Bupropion ,Aged ,business.industry ,Patient Selection ,010102 general mathematics ,Abstinence ,Nicotine replacement therapy ,Telephone ,chemistry ,Smoking cessation ,Smoking Cessation ,business - Abstract
IMPORTANCE: Persistent smoking may cause adverse outcomes among patients with cancer. Many cancer centers have not fully implemented evidence-based tobacco treatment into routine care. OBJECTIVE: To determine the effectiveness of sustained telephone counseling and medication (intensive treatment) compared with shorter-term telephone counseling and medication advice (standard treatment) to assist patients recently diagnosed with cancer to quit smoking. DESIGN, SETTING, AND PARTICIPANTS: This unblinded randomized clinical trial was conducted at Massachusetts General Hospital/Dana-Farber/Harvard Cancer Center and Memorial Sloan Kettering Cancer Center. Adults who had smoked 1 cigarette or more within 30 days, spoke English or Spanish, and had recently diagnosed breast, gastrointestinal, genitourinary, gynecological, head and neck, lung, lymphoma, or melanoma cancers were eligible. Enrollment occurred between November 2013 and July 2017; assessments were completed by the end of February 2018. INTERVENTIONS: Participants randomized to the intensive treatment (n = 153) and the standard treatment (n = 150) received 4 weekly telephone counseling sessions and medication advice. The intensive treatment group also received 4 biweekly and 3 monthly telephone counseling sessions and choice of Food and Drug Administration–approved cessation medication (nicotine replacement therapy, bupropion, or varenicline). MAIN OUTCOME AND MEASURES: The primary outcome was biochemically confirmed 7-day point prevalence tobacco abstinence at 6-month follow-up. Secondary outcomes were treatment utilization rates. RESULTS: Among 303 patients who were randomized (mean age, 58.3 years; 170 women [56.1%]), 221 (78.1%) completed the trial. Six-month biochemically confirmed quit rates were 34.5% (n = 51 in the intensive treatment group) vs 21.5% (n = 29 in the standard treatment group) (difference, 13.0% [95% CI, 3.0%-23.3%]; odds ratio, 1.92 [95% CI, 1.13-3.27]; P
- Published
- 2020