1. Brief Report: Context Matters: PrEP Adherence is Associated With Sexual Behavior Among HIV Serodiscordant Couples in East Africa
- Author
-
David R. Bangsberg, Jessica E. Haberer, Timothy R Muwonge, Renee Heffron, Connie Celum, Jared M. Baeten, Nicholas Musinguzi, Nelly Mugo, Elly Katabira, Kenneth Ngure, and Partners Mobile Adherence to PrEP (Pmap) Team
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Short Message Service ,Anti-HIV Agents ,Sexual Behavior ,Human immunodeficiency virus (HIV) ,HIV Infections ,Context (language use) ,medicine.disease_cause ,Article ,Young Adult ,03 medical and health sciences ,Pre-exposure prophylaxis ,0302 clinical medicine ,East africa ,Humans ,Medicine ,Pharmacology (medical) ,030212 general & internal medicine ,Young adult ,business.industry ,Africa, Eastern ,030112 virology ,Infectious Diseases ,Sexual behavior ,Family medicine ,Serodiscordant ,Patient Compliance ,Female ,Pre-Exposure Prophylaxis ,business - Abstract
BACKGROUND Short message service (SMS) surveys are a promising tool for understanding whether preexposure prophylaxis (PrEP) adherence aligns with risk for HIV acquisition-a concept known as prevention-effective adherence. METHODS The Partners Demonstration Project was an open-label study of integrated PrEP and antiretroviral therapy (ART) delivery among high-risk HIV serodiscordant couples in East Africa. HIV-uninfected partners were offered PrEP until their HIV-infected partner had taken ART for ≥6 months. At 2 study sites, HIV-uninfected partners were offered enrollment into the Partners Mobile Adherence to PrEP (PMAP) substudy based on ongoing PrEP use, personal cell phone ownership, and ability to use SMS. SMS surveys asked about PrEP adherence and sexual activity in the previous 24 hours; these surveys were sent daily for the 7 days before and 7 days after routine study visits in the Partners Demonstration Project. RESULTS The PMAP substudy enrolled 373 HIV-uninfected partners; 69% were men and mean age was 31 years. Participants completed 17,030 of 23,056 SMS surveys sent (74%) with a mean of 47 surveys per participant over 9.8 months of follow-up. While HIV-infected partner use of ART was
- Published
- 2017