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Your search keyword '"Bordoni, Veronica"' showing total 4 results
Start Over Author "Bordoni, Veronica" Journal jaids: journal of acquired immune deficiency syndromes
4 results on '"Bordoni, Veronica"'

4. Chronic HIV-Infected Patients Show an Impaired Dendritic Cells Differentiation of Bone Marrow CD34+ Cells.

Author

Bordoni, Veronica, Bibas, Michele, Viola, Domenico, Sacchi, Alessandra, Agrati, Chiara, Castelli, Germana, Ammassari, Adriana, Amendola, Alessandra, Abbate, Isabella, and Martini, Federico

Abstract

HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34+ HPCs to produce an adequate number of DCs. [ABSTRACT FROM AUTHOR]

Published
2013
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