Search

Your search keyword '"Di Giosia M"' showing total 2 results
Start Over Author "Di Giosia M" Journal j. mater. chem. b
2 results on '"Di Giosia M"'

2. C60@lysozyme: a new photosensitizing agent for photodynamic therapy

Author

Matteo Calvaresi, Stefania Rapino, Marco Montalti, Alice Soldà, Andrea Cantelli, Francesco Zerbetto, M. Di Giosia, Soldã , A., Cantelli, A., Di Giosia, M., Montalti, M., Zerbetto, F., Rapino, S., and Calvaresi, M.

Subjects
medicine.medical_treatment, Biomedical Engineering, Photodynamic therapy, 02 engineering and technology, 010402 general chemistry, Photochemistry, 01 natural sciences, HeLa, chemistry.chemical_compound, medicine, General Materials Science, Viability assay, Irradiation, Hydrogen peroxide, chemistry.chemical_classification, Reactive oxygen species, biology, Singlet oxygen, Medicine (all), Chemistry (all), General Chemistry, General Medicine, Photosensitizing Agent, 021001 nanoscience & nanotechnology, biology.organism_classification, 0104 chemical sciences, chemistry, Materials Science (all), 0210 nano-technology
Abstract

C60@lysozyme showed significant visible light-induced singlet oxygen generation in water, indicating the potential of this hybrid as an agent for photodynamic therapy. The reactive oxygen species (ROS) concentration generated by C60@lysozyme during irradiation depends on the light source, the irradiation time and the concentration of the hybrid. C60@lysozyme significantly reduced the HeLa cell viability in response to visible light irradiation. The generation of H2O2, due to the photoactivity of C60@lysozyme, causes cell death via easy permeation of hydrogen peroxide through the cell membrane and activation of endogenous ROS production.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results