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3. Guardian of the Furnace: Mitochondria, TRAP1, ROS and stem cell maintenance.

Author

Kadye, Rose, Kramer, Adam H., Joos‐Vandewalle, Julia, Parsons, Michelle, Njengele, Zikhona, Hoppe, Heinrich, and Prinsloo, Earl

Subjects
*MITOCHONDRIA, *OXYGEN in the body, *EUKARYOTIC cells, *TUMOR necrosis factors, *CELLULAR aging, *APOPTOSIS, *CELL differentiation
Abstract

Mitochondria are key to eukaryotic cell survival and their activity is linked to generation of reactive oxygen species (ROS) which in turn acts as both an intracellular signal and an effective executioner of cells with regards to cellular senescence. The mitochondrial molecular chaperone tumor necrosis factor receptor associated protein 1 (TRAP1) is often termed the cytoprotective chaperone for its role in cancer cell survival and protection from apoptosis. Here, we hypothesize that TRAP1 serves to modulate mitochondrial activity in stem cell maintenance, survival and differentiation. © 2013 IUBMB Life, 66(1):42-45, 2014 [ABSTRACT FROM AUTHOR]

Published
2014
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