1. Serological evidence of acute rubella infection among under-fives in Mwanza: a threat to increasing rates of congenital rubella syndrome in Tanzania
- Author
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Said Aboud, Mtebe Majigo, Martha F. Mushi, Mariam M. Mirambo, Stephen E. Mshana, Mwanaisha Seugendo, and Uwe Groß
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,IgM ,Rubella ,Under-fives ,Mwanza ,Tanzania ,Congenital rubella syndrome ,Rubella Syndrome, Congenital ,030231 tropical medicine ,Antibodies, Viral ,medicine.disease_cause ,Risk Assessment ,Emerging and Re-emerging Infectious Diseases ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,Interquartile range ,medicine ,Humans ,Seroprevalence ,Rubella Vaccine ,Serologic Tests ,030212 general & internal medicine ,Developing Countries ,2. Zero hunger ,business.industry ,Transmission (medicine) ,Research ,Incidence ,Vaccination ,Infant ,Rubella virus ,medicine.disease ,3. Good health ,Rubella Infection ,Cross-Sectional Studies ,Logistic Models ,Child, Preschool ,Communicable Disease Control ,Multivariate Analysis ,Female ,business - Abstract
BACKGROUND: Control of rubella infection is essential for preventing congenital rubella syndrome (CRS) and one of the important steps is to define a target population for vaccination. Therefore this study was done to determine serological evidence of acute rubella infection among under-fives in order to anticipate the magnitude of rubella virus transmission in Tanzania. METHODS: A cross-sectional study involving children aged between 1 and 59 months was conducted between September and October 2014 before national rubella vaccination campaigns commenced. Rubella IgM antibodies were detected using commercial indirect enzyme-linked immunosorbent assay (ELISA). Data were analyzed using STATA version 11. RESULTS: A total of230 under-fives were enrolled, their median age was 14 (Interquartile range (IQR) 7-26) months. The overall seroprevalence of rubella IgM antibodies was 10.9 % (25/230) with two confirmed cases of CRS. Two-sample Wilcoxon rank-sum test showed that the median age of rubella IgM seropositive children was significantly higher than that of IgM seronegative children (39 IQR: 18-51months vs. 14 IQR: 7-24 months, P
- Published
- 2016