22 results on '"Marseglia, G."'
Search Results
2. Children with special health care needs attending emergency department in Italy: analysis of 3479 cases
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Cianci, P., D'Apolito, V., Moretti, A., Barbagallo, M., Paci, S., Carbone, M. T., Lubrano, R., Urbino, A., Dionisi Vici, C., Memo, L., Zampino, G., La Marca, G., Villani, A., Corsello, G., Selicorni, A., Campania, A., Geremia, C., Castagno, E., Masi, S., Poggi, G., Vestri, M., Fossali, E., Rocchi, A., Dadalt, L., Arrighini, A., Chiappa, S., Renna, S., Piccotti, E., Borgna, C., Govoni, M. R., Biondi, A., Fossati, C., Iughetti, L., Bertolani, P., Salvatoni, A., Agosti, M., Fuca, F., Ilardi, A., Giuffrida, S., Diguardo, V., Boni, S., D'Antiga, L., Ruggeri, M., Chiaretti, A., Amarri, S., Peduto, A., Bernardi, F., Corsini, I., Deangelis, G. L., Ruberto, C., Zuccotti, G. V., Stringhi, C., Lombardi, G., Salladini, C., Dimichele, S., Parola, L., Porta, A., Biasucci, G., Bellini, M., Ortisi, M. T., Apuril, E., Midulla, F., Tarani, L., Parlapiano, G., Lietti, D., Sforzini, C., Marseglia, G. L., Savasta, S., Falsaperla, R., Vitaliti, M. C., Chiarelli, F., Rossi, N., Banderali, G., Giacchero, R., Bernardo, L., Pinto, F., Fabiani, E., Ficcadenti, A., Pellegrini, G., Giacoma, S., Biban, P., Spada, S., Tipo, V., Ghitti, C., Bolognini, S., Mariani, G., Russo, A., Colella, M. G., Verrico, A., Bruni, P., Poddighe, D., Cagnoli, G., Morandi, F., Gadaleta, A., Barbi, E., Bruno, I. I., Graziano, R., Sgaramella, P., Catalani, M. P., Baldoni, I., Colarusso, G., Galvagno, G., Barone, A. P., Longo, A., Nardella, G., Portale, G., Garigali, G., Bona, G., Erbela, M., Agostiniani, R., Nanni, L., Schieven, E., Dona, M., Varisco, T., Russo, F., Distefano, V. A., Dipietro, F., Tarallo, L., Imperato, L., Parisi, G., Salzano, R., Raiola, G., Talarico, V., Bellu, R., Cannone, A., Ferrante, P., Cianci, P, D'Apolito, V, Moretti, A, Barbagallo, M, Paci, S, Carbone, M, Lubrano, R, Urbino, A, Dionisi Vici, C, Memo, L, Zampino, G, La Marca, G, Villani, A, Corsello, G, Selicorni, A, Campania, A, Geremia, C, Castagno, E, Masi, S, Poggi, G, Vestri, M, Fossali, E, Rocchi, A, Dadalt, L, Arrighini, A, Chiappa, S, Renna, S, Piccotti, E, Borgna, C, Govoni, M, Biondi, A, Fossati, C, Iughetti, L, Bertolani, P, Salvatoni, A, Agosti, M, Fuca, F, Ilardi, A, Giuffrida, S, Diguardo, V, Boni, S, D'Antiga, L, Ruggeri, M, Chiaretti, A, Amarri, S, Peduto, A, Bernardi, F, Corsini, I, Deangelis, G, Ruberto, C, Zuccotti, G, Stringhi, C, Lombardi, G, Salladini, C, Dimichele, S, Parola, L, Porta, A, Biasucci, G, Bellini, M, Ortisi, M, Apuril, E, Midulla, F, Tarani, L, Parlapiano, G, Lietti, D, Sforzini, C, Marseglia, G, Savasta, S, Falsaperla, R, Vitaliti, M, Chiarelli, F, Rossi, N, Banderali, G, Giacchero, R, Bernardo, L, Pinto, F, Fabiani, E, Ficcadenti, A, Pellegrini, G, Giacoma, S, Biban, P, Spada, S, Tipo, V, Ghitti, C, Bolognini, S, Mariani, G, Russo, A, Colella, M, Verrico, A, Bruni, P, Poddighe, D, Cagnoli, G, Morandi, F, Gadaleta, A, Barbi, E, Bruno, I, Graziano, R, Sgaramella, P, Catalani, M, Baldoni, I, Colarusso, G, Galvagno, G, Barone, A, Longo, A, Nardella, G, Portale, G, Garigali, G, Bona, G, Erbela, M, Agostiniani, R, Nanni, L, Schieven, E, Dona, M, Varisco, T, Russo, F, Distefano, V, Dipietro, F, Tarallo, L, Imperato, L, Parisi, G, Salzano, R, Raiola, G, Talarico, V, Bellu, R, Cannone, A, Ferrante, P, Paola Cianci, Valeria D'Apolito, Alex Moretti, Massimo Barbagallo, Sabrina Paci, Maria Teresa Carbone, Riccardo Lubrano, Antonio Urbino, Carlo Dionisi Vici, Luigi Memo, Giuseppe Zampino, Giancarlo La Marca, Alberto Villani, Giovanni Corsello, Angelo Selicorni, Cianci, P., D'Apolito, V., Moretti, A., Barbagallo, M., Paci, S., Carbone, M. T., Lubrano, R., Urbino, A., Dionisi Vici, C., Memo, L., Zampino, G., La Marca, G., Villani, A., Corsello, G., Selicorni, A., Campania, A., Geremia, C., Castagno, E., Masi, S., Poggi, G., Vestri, M., Fossali, E., Rocchi, A., Dadalt, L., Arrighini, A., Chiappa, S., Renna, S., Piccotti, E., Borgna, C., Govoni, M. R., Biondi, A., Fossati, C., Iughetti, L., Bertolani, P., Salvatoni, A., Agosti, M., Fuca, F., Ilardi, A., Giuffrida, S., Diguardo, V., Boni, S., D'Antiga, L., Ruggeri, M., Chiaretti, A., Amarri, S., Peduto, A., Bernardi, F., Corsini, I., Deangelis, G. L., Ruberto, C., Zuccotti, G. V., Stringhi, C., Lombardi, G., Salladini, C., Dimichele, S., Parola, L., Porta, A., Biasucci, G., Bellini, M., Ortisi, M. T., Apuril, E., Midulla, F., Tarani, L., Parlapiano, G., Lietti, D., Sforzini, C., Marseglia, G. L., Savasta, S., Falsaperla, R., Vitaliti, M. C., Chiarelli, F., Rossi, N., Banderali, G., Giacchero, R., Bernardo, L., Pinto, F., Fabiani, E., Ficcadenti, A., Pellegrini, G., Giacoma, S., Biban, P., Spada, S., Tipo, V., Ghitti, C., Bolognini, S., Mariani, G., Russo, A., Colella, M. G., Verrico, A., Bruni, P., Poddighe, D., Cagnoli, G., Morandi, F., Gadaleta, A., Barbi, E., Bruno, I. I., Graziano, R., Sgaramella, P., Catalani, M. P., Baldoni, I., Colarusso, G., Galvagno, G., Barone, A. P., Longo, A., Nardella, G., Portale, G., Garigali, G., Bona, G., Erbela, M., Agostiniani, R., Nanni, L., Schieven, E., Dona, M., Varisco, T., Russo, F., Distefano, V. A., Dipietro, F., Tarallo, L., Imperato, L., Parisi, G., Salzano, R., Raiola, G., Talarico, V., Bellu, R., Cannone, A., and Ferrante, P.
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Male ,Metabolic disease ,Hospitalization rate ,Congenital skeletal condition ,Children with special health care needs ,Emergency department ,Isolated CNS malformation ,Metabolic diseases ,Multiple AED therapy ,Neuromuscular diseases ,Syndromic disorders ,True isolated microcephaly ,0302 clinical medicine ,Clinical history ,Medicine ,Child ,education.field_of_study ,Neuromuscular disease ,Settore MED/38 ,Disabled Children ,Hospitalization ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Italy ,Child, Preschool ,Female ,Children with special health care need ,Emergency Service, Hospital ,medicine.medical_specialty ,Adolescent ,Population ,Triage Code ,03 medical and health sciences ,Pharmacotherapy ,030225 pediatrics ,Humans ,Medical prescription ,education ,Retrospective Studies ,Health Services Needs and Demand ,Syndromic disorder ,business.industry ,Research ,Infant, Newborn ,Infant ,030208 emergency & critical care medicine ,Children with special health care needs, Congenital skeletal conditions,Emergency department, Hospitalization rate, Isolated CNS malformation, Metabolic diseases, Multiple AED therapy, Neuromuscular diseases, Syndromic disorders, True isolated microcephaly ,Family medicine ,Chronic Disease ,business ,Facilities and Services Utilization - Abstract
Background Although children with special health care needs (CSHCN) represent a minority of the population, they go through more hospitalizations, more admissions to the Emergency Department (ED), and receive a major number of medical prescriptions, in comparison to general pediatric population. Objectives of the study were to determine the reasons for admission to the ED in Italian CSHCN, and to describe the association between patient’s demographic data, clinical history, and health services requirements. Methods Ad hoc web site was created to collect retrospective data of 3479 visits of CSHCN to the ED in 58 Italian Hospitals. Results Seventy-two percent of patients admitted to ED were affected by a previously defined medical condition. Most of the ED admissions were children with syndromic conditions (54%). 44.2% of the ED admissions were registered during the night-time and/or at the weekends. The hospitalization rate was of 45.6% among patients admitted to the ED. The most common reason for admission to the ED was the presence of respiratory symptoms (26.6%), followed by gastrointestinal problems (21.3%) and neurological disorders (18.2%). 51.4% of the access were classified as ‘urgent’, with a red/yellow triage code. Considering the type of ED, 61.9% of the visits were conducted at the Pediatric EDs (PedEDs), 33.5% at the Functional EDs (FunEDs) and 4.6% at the Dedicated EDs (DedEDs). Patients with more complex clinical presentation were more likely to be evaluated at the PedEDs. CSHCN underwent to a higher number of medical procedures at the PedEDs, more in comparison to other EDs. Children with medical devices were directed to a PedED quite exclusively when in need for medical attention. Subjects under multiple anti-epileptic drug therapy attended to PedEDs or FunEDs generally. Patients affected by metabolic diseases were more likely to look for medical attention at FunEDs. Syndromic patients mostly required medical attention at the DedEDs. Conclusions Access of CSHCN to an ED is not infrequent. For this reason, it is fundamental for pediatricians working in any kind of ED to increase their general knowledge about CHSCN and to gain expertise in the management of such patients and their related medical complexity.
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- 2020
3. Pediatric health care professionals' vaccine knowledge, awareness and attitude: a survey within the Italian Society of Pediatric Allergy and Immunology.
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Del Duca, Elisabetta, Chini, Loredana, Graziani, Simona, Sgrulletti, Mayla, Moschese, Viviana, with the Italian Pediatric Immunology and Allergology Society (SIAIP) Vaccine Committee, Moschese, V., Chini, L., Sgrulletti, M., Dellepiane, R. M., Martire, B., Sangerardi, M., Montin, D., Ottaviano, G., Rizzo, C., Duse, M., and Marseglia, G.
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VACCINATION ,INFLUENZA vaccines ,PROFESSIONS ,IMMUNIZATION ,CONFIDENCE ,ATTITUDE (Psychology) ,MEDICAL personnel ,PEDIATRICS ,PNEUMOCOCCAL vaccines ,QUESTIONNAIRES ,PEDIATRIC nursing ,DESCRIPTIVE statistics ,ROTAVIRUS vaccines ,HERPES zoster vaccines ,NURSE practitioners - Abstract
Background: Physicians play a key role in driving vaccine acceptance and their recommendations are crucial to address vaccine hesitancy. The aim of the study was to assess knowledge, awareness and attitude of Italian Pediatric Health Care Professionals (pHCPs) on vaccinations. Methods: An anonymous on-line questionnaire was developed within the Vaccine Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP) and spontaneously completed by 231 Pediatricians and Pediatric Nurses (PN). Results: An accurate vaccine education was reported by 70% of pediatricians and 13% of PN but 11% of pediatricians versus 26% of PN consult social media instead of scientific sources for their vaccine update. The investigation on the pHCPs attitudes to vaccination in a personal and family setting highlights poor adherence to vaccinations. Only 63% of pediatricians versus 16% of PN (p < 0.0001) annually received the Flu vaccine. In their family setting 93% of pediatricians versus 51% of PN recommended all vaccinations (p < 0.0001). Anti-flu, anti-rotavirus, anti-zoster and anti-pneumococcal vaccines were not regularly recommended by all pHCPs due to doubts of uselessness (55% of pediatricians versus 40% of PN) and preference for "natural immunity" (44% of pediatricians versus 40% of PN). Conclusions: Our results indicate that pHCPs' attitude and confidence in regards to vaccines remain suboptimal. Current COVID-19 pandemic and the rapid development of vaccines could increase vaccine hesitancy. Due to the documented pHCPs' influence in the parental decision, educational interventions are needed to improve their level of knowledge and counselling skills in order to address parental vaccine hesitancy and to maintain continuity of immunization services. [ABSTRACT FROM AUTHOR]
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- 2021
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4. Prevention of recurrent respiratory infections
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Katia Perruccio, Giulia Trippella, Martina Ciarcià, Paolo Becherucci, Alberto Villani, Marco Zecca, Valeria Caldarelli, Sergio Bottero, Maria Laura Panatta, Diego Peroni, Giuseppe Di Mauro, Angela Pasinato, Lorenzo Pignataro, Sofia D’Elios, Diletta Valentini, Maurizio de Martino, Guido Morbin, Fabio Cardinale, Vito Leonardo Miniello, Massimo Pifferi, Luciana Indinnimeo, Luisa Galli, Marco Antonio Motisi, Francesca Santamaria, Gian Luigi Marseglia, Francesco Macrì, Chiara Tersigni, Anna Teresa Palamara, Michele Miraglia Del Giudice, Guido Castelli Gattinara, Paolo Biasci, Emanuela Sitzia, Renato Cutrera, Elena Chiappini, Andrea Lo Vecchio, Roberto Mattina, Daniele Ciofi, Claudio Vicini, Sandro Valentini, Paola Marchisio, Attilio Varricchio, Mattia Doria, Sara Torretta, Irene Trambusti, Andrea Novelli, Barbara Bortone, Giorgio Piacentini, Maria Carmen Verga, Sara Antonini, Chiappini, E., Santamaria, F., Marseglia, G. L., Marchisio, P., Galli, L., Cutrera, R., de Martino, M., Antonini, S., Becherucci, P., Biasci, P., Bortone, B., Bottero, S., Caldarelli, V., Cardinale, F., Gattinara, G. C., Ciarcia, M., Ciofi, D., D'Elios, S., Di Mauro, G., Doria, M., Indinnimeo, L., Lo Vecchio, A., Macri, F., Mattina, R., Miniello, V. L., del Giudice, M. M., Morbin, G., Motisi, M. A., Novelli, A., Palamara, A. T., Panatta, M. L., Pasinato, A., Peroni, D., Perruccio, K., Piacentini, G., Pifferi, M., Pignataro, L., Sitzia, E., Tersigni, C., Torretta, S., Trambusti, I., Trippella, G., Valentini, D., Valentini, S., Varricchio, A., Verga, M. C., Vicini, C., Zecca, M., and Villani, A.
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Pneumococcal Vaccine ,Complementary Therapies ,medicine.medical_specialty ,Prebiotic ,Review ,Probiotic ,Recurrent respiratory infection ,Antioxidants ,Adenoidectomy ,Pneumococcal Vaccines ,Adjuvants, Immunologic ,Quality of life ,Recurrence ,medicine ,Antibiotic Prophylaxi ,Respiratory Tract Infection ,Humans ,Recurrent respiratory infections ,Thiazolidine ,Hyaluronic Acid ,Child ,Intensive care medicine ,Respiratory Tract Infections ,Children ,Administration, Intranasal ,Tonsillectomy ,Maternal and child health ,business.industry ,Probiotics ,Prevention ,Vitamins ,Antibiotic Prophylaxis ,Settore MED/38 ,Complete resolution ,Pyrrolidonecarboxylic Acid ,Algorithm ,Prebiotics ,Immune system ,Complementary Therapie ,Influenza Vaccines ,Resveratrol ,Thiazolidines ,Antioxidant ,Influenza Vaccine ,business ,Algorithms ,Human - Abstract
Recurrent respiratory infections (RRIs) are a common clinical condition in children, in fact about 25% of children under 1 year and 6% of children during the first 6 years of life have RRIs. In most cases, infections occur with mild clinical manifestations and the frequency of episodes tends to decrease over time with a complete resolution by 12 years of age. However, RRIs significantly reduce child and family quality of life and lead to significant medical and social costs. Despite the importance of this condition, there is currently no agreed definition of the term RRIs in the literature, especially concerning the frequency and type of infectious episodes to be considered. The aim of this consensus document is to propose an updated definition and provide recommendations with the intent of guiding the physician in the complex process of diagnosis, management and prevention of RRIs. Supplementary Information The online version contains supplementary material available at 10.1186/s13052-021-01150-0.
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- 2021
5. Acute pain management in children: a survey of Italian pediatricians
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Liviana Da Dalt, Maria Alessio, Gian Luigi Marseglia, Angelo Ravelli, Maria Giuliano, Paola Marchisio, Marseglia, G. L., Alessio, M., Da Dalt, L., Giuliano, M., Ravelli, A., and Marchisio, P.
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Male ,Cross-sectional study ,Ibuprofen ,Pediatrics ,0302 clinical medicine ,Pain assessment ,Surveys and Questionnaires ,Sore throat ,Surveys and Questionnaire ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Survey ,Pain Measurement ,Pediatric ,lcsh:RJ1-570 ,Acetaminophen ,Algometric scale ,Italy ,Pain ,General Medicine ,Analgesics, Non-Narcotic ,Middle Aged ,Tolerability ,Female ,medicine.symptom ,Human ,medicine.drug ,Adult ,medicine.medical_specialty ,03 medical and health sciences ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,Pain Management ,Pediatricians ,Acute pain ,Aged ,Cross-Sectional Studie ,Dose-Response Relationship, Drug ,business.industry ,organic chemicals ,Research ,lcsh:Pediatrics ,Pain management ,Cross-Sectional Studies ,business - Abstract
BackgroundCurrent guidelines recommend assessing and relieving pain in all children and in all instances; yet, in clinical practice, management is frequently suboptimal. We investigated the attitude of Italian family pediatricians towards the evaluation and treatment of different types of acute pain in children aged 7–12 years.MethodsThis is a cross-sectional study based on a 17-question survey accessible online from October 2017 to October 2018. Responders had to describe cases of children suffering from any type of acute pain among headache, sore throat, musculoskeletal/post-traumatic pain, and earache. Children’s characteristics, pain assessment modalities and therapeutic approaches were queried. The following tests were used: Z-proportion to evaluate the distribution of categorical data; chi-squared and Kruskall-Wallis to explore data heterogeneity across groups; Mann-Whitney for head-to-head comparisons.ResultsOverall, 929 pediatricians presented 6335 cases uniformly distributed across the types examined. Pain was more frequently of moderate intensity (42.2%,P P N = 4438), the most commonly used first-line non-opioids were ibuprofen (53.3%) and acetaminophen (44.4%). Importantly, a non-recommended dosage was prescribed in only 5.3% of acetaminophen-treated cases (overdosing). Among the misconceptions emerged, there were the following: i) ibuprofen and acetaminophen have different efficacy and safety profiles (when choosing the non-opioid, effectiveness weighted more for ibuprofen [79.7% vs 74.3%,P P ConclusionsSeveral gaps exist between the current practice of pain assessment and treatment and recommendations. Further efforts are needed to raise awareness and improve education on the possible exposure of the child to short- and long-term consequences in case of suboptimal pain management.
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- 2019
6. Hexavalent vaccines in preterm infants: an update by Italian Society of Pediatric Allergy and Immunology jointly with the Italian Society of Neonatology
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Fabio Mosca, Mauro Calvani, Domenico Minasi, Chiara Petrolini, Carlo Caffarelli, Carlo Pietrasanta, Elena Chiappini, Arabella Martelli, Lorenza Pugni, Marzia Duse, G B Pajno, Mariangela Tosca, Sara Manti, Gian Luigi Marseglia, Fabio Cardinale, M. Miraglia Del Giudice, Amelia Licari, Chiappini, E., Petrolini, C., Caffarelli, C., Calvani, M., Cardinale, F., Duse, M., Licari, A., Manti, S., Martelli, A., Minasi, D., Miraglia Del Giudice, M., Pajno, G. B., Pietrasanta, C., Pugni, L., Tosca, M. A., Mosca, F., and Marseglia, G. L.
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Pediatrics ,medicine.medical_specialty ,Vaccination schedule ,Hexavalent vaccines ,Preterm infants ,Vaccines ,Review ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Humans ,Medicine ,Age Factor ,Hexavalent vaccine ,Vaccines, Combined ,030212 general & internal medicine ,Neonatology ,Adverse effect ,Immunization Schedule ,Age Factors ,Infant ,Infant, Newborn ,Infant, Premature ,Italy ,Practice Guidelines as Topic ,business.industry ,Tetanus ,Diphtheria ,lcsh:RJ1-570 ,lcsh:Pediatrics ,medicine.disease ,Vaccination ,Immunization ,Preterm infant ,Vaccine-preventable diseases ,business ,Vaccine ,Human - Abstract
Hexavalent vaccines, protecting against six diseases (diphtheria, tetanus, pertussis [DTaP], poliovirus, hepatitis B virus [HBV], and Haemophilus influenzae type b [Hib], are routinely the standard of care in Europe. The use of combined vaccines allows the reduction of number of injections and side effects, the reduction of costs, and the increase in adherence of the family to the vaccination schedule both in terms of the number of doses and timing. The safety profile, efficacy and effectiveness of hexavalent vaccines have been extensively documented in infants and children born at term, and data are accumulating in preterm infants. Hexavalent vaccines are particularly important for preterm infants, who are at increased risk for severe forms of vaccine preventable diseases. However, immunization delay has been commonly reported in this age group. All the three hexavalent vaccines currently marketed in Italy can be used in preterm infants, and recent data confirm that hexavalent vaccines have a similar or lower incidence of adverse events in preterm compared to full-term infants; this is likely due to a weaker immune system response and reduced ability to induce an inflammatory response in preterm infants. Apnoea episodes are the adverse events that can occur in the most severe preterm infants and / or with history of respiratory distress. The risk of apnoea after vaccination seems to be related to a lower gestational age and a lower birth weight, supporting the hypothesis that it represents an unspecific response of the preterm infant to different procedures. High seroprotection rates have been reported in preterm infants vaccinated with hexavalent vaccine. However, a lower gestational age seems to be associated with lower antibody titres against some vaccine antigens (e.g. HBV, Hib, poliovirus serotype 1, and pertussis), regardless of the type of hexavalent vaccine used. Waiting for large effectiveness studies, hexavalent vaccines should be administered in preterm infants according to the same schedule recommended for infants born at term, considering their chronological age and providing an adequate monitoring for cardio-respiratory events in the 48–72 h after vaccination, especially for infants at risk of recurrence of apnoea.
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- 2019
7. Consensus communication strategies to improve doctor-patient relationship in paediatric severe asthma
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Antonietta Cappuccio, on behalf of Paediatric Sound Group, Filomena Bugliaro, Silvia Maria Elena Caimmi, Valeria Caldarelli, Lucia Caminiti, Enza D’Auria, Emanuela di Palmo, Marzia Duse, Alessandro Giovanni Fiocchi, Francesco Gesualdo, Ahmad Kantar, Enrico Lombardi, Anna Lucania, Margherita Marchiani, Maria Giulia Marini, Gianluigi Marseglia, Maria Carmela Montera, Elio Massimo Novembre, Guido Pellegrini, Giorgio Piacentini, Alessandro Policreti, Francesca Santamaria, Cappuccio, A., Bugliaro, F., Caimmi, S. M. E., Caldarelli, V., Caminiti, L., D'Auria, E., Di Palmo, E., Duse, M., Fiocchi, A. G., Gesualdo, F., Kantar, A., Lombardi, E., Lucania, A., Marchiani, M., Marini, M. G., Marseglia, G., Montera, M. C., Novembre, E. M., Pellegrini, G., Piacentini, G., Policreti, A., and Santamaria, F.
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Male ,Severe asthma ,medicine.medical_specialty ,Consensus ,Quality management ,Adolescent ,Attitude of Health Personnel ,Consensu ,Context (language use) ,Pediatrics ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Severity of illness ,medicine ,Humans ,030212 general & internal medicine ,Parent-Child Relations ,Preschool ,Child ,education ,Asthma ,Pediatric ,Narrative medicine ,Physician-Patient Relations ,education.field_of_study ,Physician-Patient Relation ,business.industry ,Research ,Communication ,lcsh:RJ1-570 ,communication ,consensus ,doctor-patient relationship ,paediatric ,severe asthma ,adolescent ,asthma ,child ,child, preschool ,female ,humans ,male ,parent-child relations ,pediatrics ,severity of illness index ,attitude of health personnel ,physician-patient relations ,quality improvement ,lcsh:Pediatrics ,Doctor-patient relationship ,medicine.disease ,Quality Improvement ,Comprehension ,Paediatric ,Child, Preschool ,Family medicine ,Doctor–patient relationship ,Female ,Working group ,business ,Human ,Parent-Child Relation - Abstract
Background Asthma is a chronic inflammatory disease that is very common among youth worldwide. The burden of this illness is very high not only considering financial costs but also on emotional and social functioning. Guidelines and many researches recommend to develop a good communication between physicians and children/caregiver and their parents. Nevertheless, a previous Italian project showed some criticalities in paediatric severe asthma management. The consensus gathered together experts in paediatric asthma management, experts in narrative medicine and patient associations with the aim of identify simple recommendation to improve communication strategies. Methods Participants to the consensus received the results of the project and a selection of narratives two weeks before the meeting. The meeting was structured in plenary session and in three working groups discussing respectively about communication strategies with children, adolescents and parents. The task of each working group was to identify the most effective (DO) and least effective practices (DON’ T) for 5 phases of the visit: welcome, comprehension of the context, emotions management, duration and end of the visit and endurance of the relationship. Results Participants agreed that good relationships translate into positive outcomes and reached consensus on communication strategies to implement in the different phase of relationships. Conclusions The future challenges identified by the participants are the dissemination of this Consensus document and the implementation of effective communication strategies to improve the management of pediatric asthma.
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- 2019
8. Probiotics and food allergy
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Davide Caimmi, Amelia Licari, Gian Luigi Marseglia, Salvatore Leonardi, Alessia Marseglia, Anna Maria Castellazzi, Silvia Caimmi, Mario La Rosa, Maria Chiara Leoni, Chiara Valsecchi, Michele Miraglia Del Giudice, Castellazzi, Am, Valsecchi, C, Caimmi, S, Licari, A, Marseglia, A, Leoni, Mc, Caimmi, D, MIRAGLIA DEL GIUDICE, Michele, Leonardi, S, La Rosa, M, and Marseglia, G. L.
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Allergy ,Intestinal microbiota ,Population ,Review ,Immunoglobulin E ,Immune tolerance ,Immune system ,Antigen ,Hygiene hypothesis ,Food allergy ,Allergic disease ,medicine ,Humans ,Immunologic Factors ,Child ,education ,Children ,education.field_of_study ,Evidence-Based Medicine ,biology ,business.industry ,Probiotics ,medicine.disease ,Gastrointestinal Tract ,Treatment Outcome ,Immunology ,biology.protein ,business ,Biomarkers ,Food Hypersensitivity - Abstract
The exact prevalence of food allergy in the general population is unknown, but almost 12% of pediatric population refers a suspicion of food allergy. IgE mediated reactions to food are actually the best-characterized types of allergy, and they might be particularly harmful especially in children. According to the “hygiene hypothesis” low or no exposure to exogenous antigens in early life may increase the risk of allergic diseases by both delaying the development of the immune tolerance and limiting the Th2/Th1 switch. The critical role of intestinal microbiota in the development of immune tolerance improved recently the interest on probiotics, prebiotics, antioxidants, polyunsaturated fatty acid, folate and vitamins, which seem to have positive effects on the immune functions. Probiotics consist in bacteria or yeast, able to re-colonize and restore microflora symbiosis in intestinal tract. One of the most important characteristics of probiotics is their safety for human health. Thanks to their ability to adhere to intestinal epithelial cells and to modulate and stabilize the composition of gut microflora, probiotics bacteria may play an important role in the regulation of intestinal and systemic immunity. They actually seem capable of restoring the intestinal microbic equilibrium and modulating the activation of immune cells. Several studies have been recently conducted on the role of probiotics in preventing and/or treating allergic disorders, but the results are often quite contradictory, probably because of the heterogeneity of strains, the duration of therapy and the doses administered to patients. Therefore, new studies are needed in order to clarify the functions and the utility of probiotics in food allergies and ion other types of allergic disorders.
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9. Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry.
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Calcaterra V, Tornese G, Zuccotti G, Staiano A, Cherubini V, Gaudino R, Fazzi EM, Barbi E, Chiarelli F, Corsello G, Esposito SMR, Ferrara P, Iughetti L, Laforgia N, Maghnie M, Marseglia G, Perilongo G, Pettoello-Mantovani M, Ruggieri M, Russo G, Salerno M, Striano P, Valerio G, and Wasniewska M
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- Humans, Child, Adolescent, Male, Female, Gender Identity, Italy, Adolescent Medicine, Gender Dysphoria therapy, Neuropsychiatry, Diabetes Mellitus
- Abstract
Background: In response to the imperative need for standardized support for adolescent Gender Dysphoria (GD), the Italian Academy of Pediatrics, in collaboration with the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, Italian Society of Adolescent Medicine and Italian Society of Child and Adolescent Neuropsychiatry is drafting a position paper. The purpose of this paper is to convey the author's opinion on the topic, offering foundational information on potential aspects of gender-affirming care and emphasizing the care and protection of children and adolescents with GD., Main Body: Recognizing that adolescents may choose interventions based on their unique needs and goals and understanding that every individual within this group has a distinct trajectory, it is crucial to ensure that each one is welcomed and supported. The approach to managing individuals with GD is a multi-stage process involving a multidisciplinary team throughout all phases. Decisions regarding treatment should be reached collaboratively by healthcare professionals and the family, while considering the unique needs and circumstances of the individual and be guided by scientific evidence rather than biases or ideologies. Politicians and high court judges should address discrimination based on gender identity in legislation and support service development that aligns with the needs of young people. It is essential to establish accredited multidisciplinary centers equipped with the requisite skills and experience to effectively manage adolescents with GD, thereby ensuring the delivery of high-quality care., Conclusion: Maintaining an evidence-based approach is essential to safeguard the well-being of transgender and gender diverse adolescents., (© 2024. The Author(s).)
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- 2024
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10. Present and future are getting confused: are we equipped to face the technological revolution?
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Perilongo G, Agostiniani R, Corsello G, Marseglia G, Muraca M, Staiano AM, Zuccotti G, and Baraldi E
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- Humans, Italy, Forecasting, Technology
- Abstract
Background: This is a commentary reporting the outcome of a workshop promoted by the Department of Woman's and Child's Health of the University of Padua (Italy) focused on the emerging issue of what seems to be the increasing agemone role of technology., Main Body: Over the centuries, technology has always been at the service of science, with theoretical insights anticipating experimental proofs. Over the last decades, however, the situation has radically changed, due to several factors. Technology seems to be playing an agemone role. The present and notably the future generation of scientists have major challenges to face. They have to deal with the forces generated by the infosphera; to dominate the technology and to maintain the capacity of generating inquisitive, creative, ethical and spiritual thoughts capable of addressing new scientific hypotheses and projects directed to the individual and collective good. However, in this scenario, what seems more relevant is to focus all our efforts in preparing ourselves, first, and then the new generations to face these challenges. From this point of view, the academic institutions and the scientific societies, have a major responsibility to deal with., Conclusions: The academic ecosystem traditionally used to educate the new generation of professionals as well as, and most importantly, the cultural, the professional pathways presently used to form them need to be extensively revised. The time is running short and the stakes are high. The debate is open., (© 2023. The Author(s).)
- Published
- 2023
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11. Correction: Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases.
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Duse M, Santamaria F, Verga MC, Bergamini M, Simeone G, Leonardi L, Tezza G, Bianchi A, Capuano A, Cardinale F, Cerimoniale G, Landi M, Malventano M, Tosca M, Varricchio A, Zicari AM, Alfaro C, Barberi S, Becherucci P, Bernardini R, Biasci P, Caffarelli C, Caldarelli V, Capristo C, Castronuovo S, Chiappini E, Cutrera R, De Castro G, De Franciscis L, Decimo F, Iacono ID, Diaferio L, Di Cicco ME, Di Mauro C, Di Mauro C, Di Mauro D, Di Mauro F, Di Mauro G, Doria M, Falsaperla R, Ferraro V, Fanos V, Galli E, Ghiglioni DG, Indinnimeo L, Kantar A, Lamborghini A, Licari A, Lubrano R, Luciani S, Macrì F, Marseglia G, Martelli AG, Masini L, Midulla F, Minasi D, Miniello VL, Del Giudice MM, Morandini SR, Nardini G, Nocerino A, Novembre E, Pajno GB, Paravati F, Piacentini G, Piersantelli C, Pozzobon G, Ricci G, Spanevello V, Turra R, Zanconato S, Borrelli M, Villani A, Corsello G, Di Mauro G, and Peroni D
- Published
- 2022
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12. Eligibility criteria for pediatric patients who may benefit from anti SARS-CoV-2 monoclonal antibody therapy administration: an Italian inter-society consensus statement.
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Lanari M, Venturini E, Pierantoni L, Stera G, Castelli Gattinara G, Esposito SMR, Favilli S, Franzoni E, Fusco E, Lionetti P, Maffeis C, Marseglia G, Massella L, Midulla F, Zanobini A, Zecca M, Villani A, Staiano A, and Galli L
- Subjects
- Adolescent, Age Factors, COVID-19 complications, Child, Consensus, Drug Combinations, Humans, Italy, Risk Factors, Societies, Medical, Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Antibodies, Neutralizing therapeutic use, Antiviral Agents therapeutic use, Patient Selection, COVID-19 Drug Treatment
- Abstract
The fast diffusion of the SARS-CoV-2 pandemic have called for an equally rapid evolution of the therapeutic options.The Human recombinant monoclonal antibodies (mAbs) have recently been approved by the Food and Drug Administration (FDA) and by the Italian Medicines Agency (AIFA) in subjects aged ≥12 with SARS-CoV-2 infection and specific risk factors.Currently the indications are specific for the use of two different mAbs combination: Bamlanivimab+Etesevimab (produced by Eli Lilly) and Casirivimab+Imdevimab (produced by Regeneron).These drugs have shown favorable effects in adult patients in the initial phase of infection, whereas to date few data are available on their use in children.AIFA criteria derived from the existing literature which reports an increased risk of severe COVID-19 in children with comorbidities. However, the studies analyzing the determinants for progression to severe disease are mainly monocentric, with limited numbers and reporting mostly generic risk categories.Thus, the Italian Society of Pediatrics invited its affiliated Scientific Societies to produce a Consensus document based on the revision of the criteria proposed by AIFA in light of the most recent literature and experts' agreement.This Consensus tries to detail which patients actually have the risk to develop severe disease, analyzing the most common comorbidities in children, in order to detail the indications for mAbs administration and to guide the clinicians in identifying eligible patients., (© 2022. The Author(s).)
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- 2022
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13. Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases.
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Duse M, Santamaria F, Verga MC, Bergamini M, Simeone G, Leonardi L, Tezza G, Bianchi A, Capuano A, Cardinale F, Cerimoniale G, Landi M, Malventano M, Tosca M, Varricchio A, Zicari AM, Alfaro C, Barberi S, Becherucci P, Bernardini R, Biasci P, Caffarelli C, Caldarelli V, Capristo C, Castronuovo S, Chiappini E, Cutrera R, De Castro G, De Franciscis L, Decimo F, Iacono ID, Diaferio L, Di Cicco ME, Di Mauro C, Di Mauro C, Di Mauro D, Di Mauro F, Di Mauro G, Doria M, Falsaperla R, Ferraro V, Fanos V, Galli E, Ghiglioni DG, Indinnimeo L, Kantar A, Lamborghini A, Licari A, Lubrano R, Luciani S, Macrì F, Marseglia G, Martelli AG, Masini L, Midulla F, Minasi D, Miniello VL, Del Giudice MM, Morandini SR, Nardini G, Nocerino A, Novembre E, Pajno GB, Paravati F, Piacentini G, Piersantelli C, Pozzobon G, Ricci G, Spanevello V, Turra R, Zanconato S, Borrelli M, Villani A, Corsello G, Di Mauro G, and Peroni D
- Subjects
- Administration, Inhalation, Adolescent, Child, Child, Preschool, Consensus, Delphi Technique, Female, Humans, Infant, Italy, Male, Societies, Medical, Adrenal Cortex Hormones administration & dosage, Respiratory Tract Diseases drug therapy
- Abstract
Background: In 2019, a multidisciplinary panel of experts from eight Italian scientific paediatric societies developed a consensus document for the use of inhaled corticosteroids in the management and prevention of the most common paediatric airways disorders. The aim is to provide healthcare providers with a multidisciplinary document including indications useful in the clinical practice. The consensus document was intended to be addressed to paediatricians who work in the Paediatric Divisions, the Primary Care Services and the Emergency Departments, as well as to Residents or PhD students, paediatric nurses and specialists or consultants in paediatric pulmonology, allergy, infectious diseases, and ear, nose, and throat medicine., Methods: Clinical questions identifying Population, Intervention(s), Comparison and Outcome(s) were addressed by methodologists and a general agreement on the topics and the strength of the recommendations (according to the GRADE system) was obtained following the Delphi method. The literature selection included secondary sources such as evidence-based guidelines and systematic reviews and was integrated with primary studies subsequently published., Results: The expert panel provided a number of recommendations on the use of inhaled corticosteroids in preschool wheezing, bronchial asthma, allergic and non-allergic rhinitis, acute and chronic rhinosinusitis, adenoid hypertrophy, laryngitis and laryngospasm., Conclusions: We provided a multidisciplinary update on the current recommendations for the management and prevention of the most common paediatric airways disorders requiring inhaled corticosteroids, in order to share useful indications, identify gaps in knowledge and drive future research.
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- 2021
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14. Abdominal pain as first manifestation of lyme neuroborreliosis in children, case report and review of literature.
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Savasta S, Fiorito I, Foiadelli T, Pichiecchio A, Cambieri P, Mariani B, Marone P, and Marseglia G
- Subjects
- Child, Humans, Lyme Neuroborreliosis therapy, Male, Abdominal Pain virology, Lyme Neuroborreliosis complications, Lyme Neuroborreliosis diagnosis
- Abstract
Background: Lyme neuroborreliosis can cause a variety of neurological manifestations. European children usually present facial nerve palsy, other cranial nerve palsies and aseptic meningitis., Case Presentation: We hereby report a case of Lyme neuroborreliosis in a 9-year-old boy with abdominal pain as first symptom and subsequent onset of attention deficit and ataxia. Diagnosis was made by detection of specific antibody in both serum and cerebrospinal fluid with neuro-radiological images suggestive for this infectious disease. A 12-months follow-up was performed during which no relevant neurological sequelae were revealed., Conclusion: This case report shows that abdominal radiculitis, although extremely rare, could be the first manifestation of early Lyme neuroborreliosis in pediatric patients. Pediatricians must consider Lyme disease in the differential diagnosis of abdominal pain of unknown origin in children, especially in countries where the infection is endemic.
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- 2020
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15. Hexavalent vaccines in preterm infants: an update by Italian Society of Pediatric Allergy and Immunology jointly with the Italian Society of Neonatology.
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Chiappini E, Petrolini C, Caffarelli C, Calvani M, Cardinale F, Duse M, Licari A, Manti S, Martelli A, Minasi D, Miraglia Del Giudice M, Pajno GB, Pietrasanta C, Pugni L, Tosca MA, Mosca F, and Marseglia GL
- Subjects
- Age Factors, Humans, Infant, Infant, Newborn, Infant, Premature, Italy, Practice Guidelines as Topic, Immunization Schedule, Vaccines, Combined administration & dosage, Vaccines, Combined adverse effects
- Abstract
Hexavalent vaccines, protecting against six diseases (diphtheria, tetanus, pertussis [DTaP], poliovirus, hepatitis B virus [HBV], and Haemophilus influenzae type b [Hib], are routinely the standard of care in Europe. The use of combined vaccines allows the reduction of number of injections and side effects, the reduction of costs, and the increase in adherence of the family to the vaccination schedule both in terms of the number of doses and timing. The safety profile, efficacy and effectiveness of hexavalent vaccines have been extensively documented in infants and children born at term, and data are accumulating in preterm infants. Hexavalent vaccines are particularly important for preterm infants, who are at increased risk for severe forms of vaccine preventable diseases. However, immunization delay has been commonly reported in this age group. All the three hexavalent vaccines currently marketed in Italy can be used in preterm infants, and recent data confirm that hexavalent vaccines have a similar or lower incidence of adverse events in preterm compared to full-term infants; this is likely due to a weaker immune system response and reduced ability to induce an inflammatory response in preterm infants. Apnoea episodes are the adverse events that can occur in the most severe preterm infants and / or with history of respiratory distress. The risk of apnoea after vaccination seems to be related to a lower gestational age and a lower birth weight, supporting the hypothesis that it represents an unspecific response of the preterm infant to different procedures. High seroprotection rates have been reported in preterm infants vaccinated with hexavalent vaccine. However, a lower gestational age seems to be associated with lower antibody titres against some vaccine antigens (e.g. HBV, Hib, poliovirus serotype 1, and pertussis), regardless of the type of hexavalent vaccine used. Waiting for large effectiveness studies, hexavalent vaccines should be administered in preterm infants according to the same schedule recommended for infants born at term, considering their chronological age and providing an adequate monitoring for cardio-respiratory events in the 48-72 h after vaccination, especially for infants at risk of recurrence of apnoea.
- Published
- 2019
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16. Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice.
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Licari A, Fuchs D, Marseglia G, and Ciprandi G
- Subjects
- Adolescent, Case-Control Studies, Child, Cross-Sectional Studies, Female, Humans, Male, Metabolic Networks and Pathways, Asthma metabolism, Neopterin metabolism, Tryptophan metabolism
- Abstract
Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 years) and well-matched healthy controls (63, 32 males, 31 females, mean age 10.7 + 2.6 years). Tryptophan, kynurenine, and neopterin levels were significantly higher in asthmatic children than in healthy controls (p < 0.01; p < 0.01; p = 0.0015 respectively). Tryptophan metabolites and neopterin are increased in asthmatic children; these mediators underline the complex mechanisms involved in the immune response in asthma.
- Published
- 2019
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17. A polycentric, randomized, parallel-group, study on Lertal®, a multicomponent nutraceutical, as preventive treatment in children with allergic rhinoconjunctivitis: phase II.
- Author
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Marseglia G, Licari A, Leonardi S, Papale M, Zicari AM, Schiavi L, and Ciprandi G
- Subjects
- Child, Cholecalciferol, Double-Blind Method, Female, Humans, Male, Perilla, Quercetin, Tablets, Conjunctivitis, Allergic drug therapy, Dietary Supplements
- Abstract
Background: Lertal®, an oral nutraceutical, contains extract of Perilla, quercetin, and Vitamin D3. The current polycentric, randomized, parallel-group, controlled study aimed in the Phase II to evaluate the efficacy and safety of Lertal® in preventing allergic rhinitis (AR) exacerbations in children after the end of the pharmacological treatment phase., Materials and Methods: One hundred twenty-eight children completed Phase II. Sixty-four children continued Lertal® treatment (Lertal® Group: LG) and 64 ones did not assume any medication (Observation Group: OG) for 4-12 weeks. The study endpoints were the number, intensity, and duration of AR exacerbations, and the length of symptom-free time., Results: Children of LG halved the risk (HR = 0.54) of having AR exacerbation. Children of LG had significantly (p = 0.039) less AR exacerbations than OG children. In children with AR exacerbations, the total number of days in which each patient took at least one rescue medication was significantly (p = 0.018) lesser in LG children than OG ones. In the global population, the cumulative days treated with rescue medication was significantly (p < 0.0001) higher in OG than in LG. There was no clinically relevant adverse event., Conclusions: The present study documented that prolonged Lertal® assumption was safe and able to significantly reduce, such as halving, the risk of AR exacerbation, their duration and the use of rescue medications, after the suspension of the one-month antihistamine treatment. Therefore, Lertal® could be envisaged as an effective preventive treatment in AR children able to guarantee long symptom-free time., Trial Registration: Clinical trial registration: ClinicalTrials gov ID NCT03365648 .
- Published
- 2019
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18. Consensus communication strategies to improve doctor-patient relationship in paediatric severe asthma.
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Cappuccio A, Bugliaro F, Caimmi SME, Caldarelli V, Caminiti L, D'Auria E, di Palmo E, Duse M, Fiocchi AG, Gesualdo F, Kantar A, Lombardi E, Lucania A, Marchiani M, Marini MG, Marseglia G, Montera MC, Novembre EM, Pellegrini G, Piacentini G, Policreti A, and Santamaria F
- Subjects
- Adolescent, Asthma diagnosis, Child, Child, Preschool, Communication, Female, Humans, Male, Parent-Child Relations, Pediatrics education, Severity of Illness Index, Asthma therapy, Attitude of Health Personnel, Consensus, Physician-Patient Relations, Quality Improvement
- Abstract
Background: Asthma is a chronic inflammatory disease that is very common among youth worldwide. The burden of this illness is very high not only considering financial costs but also on emotional and social functioning. Guidelines and many researches recommend to develop a good communication between physicians and children/caregiver and their parents. Nevertheless, a previous Italian project showed some criticalities in paediatric severe asthma management. The consensus gathered together experts in paediatric asthma management, experts in narrative medicine and patient associations with the aim of identify simple recommendation to improve communication strategies., Methods: Participants to the consensus received the results of the project and a selection of narratives two weeks before the meeting. The meeting was structured in plenary session and in three working groups discussing respectively about communication strategies with children, adolescents and parents. The task of each working group was to identify the most effective (DO) and least effective practices (DON' T) for 5 phases of the visit: welcome, comprehension of the context, emotions management, duration and end of the visit and endurance of the relationship., Results: Participants agreed that good relationships translate into positive outcomes and reached consensus on communication strategies to implement in the different phase of relationships., Conclusions: The future challenges identified by the participants are the dissemination of this Consensus document and the implementation of effective communication strategies to improve the management of pediatric asthma.
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- 2019
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19. SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.
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Caffarelli C, Franceschini F, Caimmi D, Mori F, Diaferio L, Di Mauro D, Mastrorilli C, Arasi S, Barni S, Bottau P, Caimmi S, Cardinale F, Comberiati P, Crisafulli G, Liotti L, Pelosi U, Saretta F, Marseglia G, Duse M, and Paravati F
- Subjects
- Child, Humans, Anti-Bacterial Agents adverse effects, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Drug Hypersensitivity diagnosis
- Abstract
Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), that aims of ascertaining the causative role of an allergen and evaluating the tolerance to the suspected drug. Different protocols through the administration of divided increasing doses have been postulated according to the type of drug and the onset of the reaction (immediate or non immediate reactions). DPT protocols differ in doses and time interval between doses. In this position paper, the Italian Pediatric Society for Allergy and Immunology provides a practical guide for provocation test to antibiotics and NSAIDs in children and adolescents.
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- 2018
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20. Kawasaki disease: guidelines of Italian Society of Pediatrics, part II - treatment of resistant forms and cardiovascular complications, follow-up, lifestyle and prevention of cardiovascular risks.
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Marchesi A, Tarissi de Jacobis I, Rigante D, Rimini A, Malorni W, Corsello G, Bossi G, Buonuomo S, Cardinale F, Cortis E, De Benedetti F, De Zorzi A, Duse M, Del Principe D, Dellepiane RM, D'Isanto L, El Hachem M, Esposito S, Falcini F, Giordano U, Maggio MC, Mannarino S, Marseglia G, Martino S, Marucci G, Massaro R, Pescosolido C, Pietraforte D, Pietrogrande MC, Salice P, Secinaro A, Straface E, and Villani A
- Subjects
- Cardiovascular Diseases diagnosis, Cardiovascular Diseases epidemiology, Child, Child, Preschool, Coronary Artery Disease diagnosis, Coronary Artery Disease drug therapy, Coronary Artery Disease epidemiology, Female, Follow-Up Studies, Humans, Male, Mucocutaneous Lymph Node Syndrome diagnosis, Mucocutaneous Lymph Node Syndrome epidemiology, Pediatrics, Risk Assessment, Severity of Illness Index, Societies, Medical, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Cardiovascular Diseases drug therapy, Drug Resistance, Immunoglobulins, Intravenous therapeutic use, Mucocutaneous Lymph Node Syndrome drug therapy, Practice Guidelines as Topic
- Abstract
This second part of practical Guidelines related to Kawasaki disease (KD) has the goal of contributing to prompt diagnosis and most appropriate treatment of KD resistant forms and cardiovascular complications, including non-pharmacologic treatments, follow-up, lifestyle and prevention of cardiovascular risks in the long-term through a set of 17 recommendations.Guidelines, however, should not be considered a norm that limits the treatment options of pediatricians and practitioners, as treatment modalities other than those recommended may be required as a result of peculiar medical circumstances, patient's condition, and disease severity or individual complications.
- Published
- 2018
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21. Kawasaki disease: guidelines of the Italian Society of Pediatrics, part I - definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase.
- Author
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Marchesi A, Tarissi de Jacobis I, Rigante D, Rimini A, Malorni W, Corsello G, Bossi G, Buonuomo S, Cardinale F, Cortis E, De Benedetti F, De Zorzi A, Duse M, Del Principe D, Dellepiane RM, D'Isanto L, El Hachem M, Esposito S, Falcini F, Giordano U, Maggio MC, Mannarino S, Marseglia G, Martino S, Marucci G, Massaro R, Pescosolido C, Pietraforte D, Pietrogrande MC, Salice P, Secinaro A, Straface E, and Villani A
- Subjects
- Acute Disease, Disease Management, Disease Progression, Female, Humans, Italy, Male, Mucocutaneous Lymph Node Syndrome epidemiology, Pediatrics standards, Prognosis, Randomized Controlled Trials as Topic, Retrospective Studies, Risk Assessment, Severity of Illness Index, Societies, Medical, Treatment Outcome, Immunoglobulins, Intravenous administration & dosage, Mucocutaneous Lymph Node Syndrome diagnosis, Mucocutaneous Lymph Node Syndrome therapy, Practice Guidelines as Topic
- Abstract
The primary purpose of these practical guidelines related to Kawasaki disease (KD) is to contribute to prompt diagnosis and appropriate treatment on the basis of different specialists' contributions in the field. A set of 40 recommendations is provided, divided in two parts: the first describes the definition of KD, its epidemiology, etiopathogenetic hints, presentation, clinical course and general management, including treatment of the acute phase, through specific 23 recommendations.Their application is aimed at improving the rate of treatment with intravenous immunoglobulin and the overall potential development of coronary artery abnormalities in KD. Guidelines, however, should not be considered a norm that limits treatment options of pediatricians and practitioners, as treatment modalities other than those recommended may be required as a result of peculiar medical circumstances, patient's condition, and disease severity or complications.
- Published
- 2018
- Full Text
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22. Nasal cytology in children: recent advances.
- Author
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Gelardi M, Luigi Marseglia G, Licari A, Landi M, Dell'Albani I, Incorvaia C, Frati F, and Quaranta N
- Subjects
- Child, Humans, Immunotherapy methods, Nose Diseases immunology, Nose Diseases physiopathology, Nose Diseases therapy, Rhinitis immunology, Rhinitis pathology, Rhinitis physiopathology, Rhinitis therapy, Cytodiagnosis methods, Nasal Mucosa cytology, Nose Diseases pathology
- Abstract
Nasal cytology is a very useful diagnostic tool in nasal disorders, being able to detect both the cellular modifications of the nasal epithelium caused by either allergen exposure or irritative stimuli (that may be physical or chemical, acute or chronic), or inflammation. Over these past few years, nasal cytology has allowed to identify new disorders, such as the non-allergic rhinitis with eosinophils (NARES), the non-allergic rhinitis with mast cells (NARMA), the non-allergic rhinitis with neutrophils (NARNE), and the non-allergic rhinitis with eosinophils and mast cells (NARESMA). The rhinocytogram is actually able to distinguish the different forms of allergic rhinitis and to suggest the appropriate treatment, such as antinflammatory drugs or allergen immunotherapy. The technique is easy to perform and nasal cytology is therefore particularly suitable even for children. Such a consideration suggests the utility of a systematic use of nasal cytology in the diagnostic work-up of nasal disorders in children, in order to reach a proper defined diagnosis and to set a rational therapeutic approach: in facts, these two elements are fundamental in order to prevent from complications and to improve the patient's quality of life.
- Published
- 2012
- Full Text
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