1. Anesthesia in Parturients Presenting with Marfan Syndrome.
- Author
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Weinstein J, Shinfeld A, Simchen M, Cahan T, Frogel J, Arad M, Berkenstadt H, and Kuperstein R
- Subjects
- Adult, Female, Humans, Interdisciplinary Communication, Israel epidemiology, Monitoring, Physiologic methods, Outcome and Process Assessment, Health Care, Pregnancy, Pregnancy Outcome epidemiology, Pregnancy, High-Risk, Anesthesia, Obstetrical adverse effects, Anesthesia, Obstetrical methods, Anesthesia, Obstetrical statistics & numerical data, Aortic Dissection diagnosis, Aortic Dissection prevention & control, Aortic Diseases complications, Aortic Diseases diagnosis, Aortic Diseases etiology, Delivery, Obstetric adverse effects, Delivery, Obstetric methods, Delivery, Obstetric statistics & numerical data, Marfan Syndrome complications, Marfan Syndrome epidemiology, Marfan Syndrome physiopathology, Obstetric Labor Complications diagnosis, Obstetric Labor Complications etiology, Obstetric Labor Complications prevention & control, Pregnancy Complications diagnosis, Pregnancy Complications physiopathology, Pregnancy Complications therapy
- Abstract
Background: Pregnant women with Marfan syndrome (MS) have a high risk of aortic dissection around delivery and their optimal management requires a multi-disciplinary approach, including proper cardio-obstetric care and adequate pain management during labor, which may be difficult due to the high prevalence of dural ectasia (DE) in these patients., Objectives: To evaluate the multidisciplinary management of MS patients during labor., Methods: Nineteen pregnant women (31 pregnancies) with MS were followed by a multi-disciplinary team (cardiologist, obstetrician, anesthesiologist) prior to delivery., Results: Two patients had kyphoscoliosis; none had previous spine surgery nor complaints compatible with DE. In eight pregnancies (7 patients), aortic root diameter (ARd) before pregnancy was 40 to 46 mm. In this high-risk group, one patient underwent elective termination, two underwent an urgent cesarean section (CS) under general anesthesia, and five had elective CS; two under general anesthesia (GA), and three under spinal anesthesia. In 23 pregnancies (12 patients), ARd was < 40 mm. In this non-high-risk group three pregnancies (1 patient) were electively terminated. Of the remaining 20 deliveries (11 patients), 14 were vaginal deliveries, 9 with epidural analgesia and 5 without. Six patients had a CS; four under GA and two2 under spinal anesthesia. There were no epidural placement failures and no failed responses. There were 2 cases of aortic dissection, unrelated to the anesthetic management., Conclusions: The optimal anesthetic strategy during labor in MS patients should be decided by a multi-disciplinary team. Anesthetic complications due to DE were not encountered during neuraxial block.
- Published
- 2021