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�Ct method. Paired t-tests were used to compare baseline and post-exposure samples. Results : Expression profiling of 88 human miRNAs extracted from baseline and paired post-exposure blood samples identified 6 miRNAs which showed significant differential expression between the two samples. Among the most notable changes were miR-302c and miR-128 which were up-regulated by 13.9- and 5.6-fold respectively (p

Background and Aims: asbestos fibers naturally present in rocks and soils can be released into the atmosphere by occupational and other human activities, as well as by meteorological agents. The ai...

Background and Aims. Shortened leukocyte telomere length (LTL) is a marker of cardiovascular risk that has been recently associated w ith long-term exposure to ambient particulate matter (PM). How ...

Background and Aims: Epidemiological findings suggest an association between particulate matter (PM) exposure and hypercoagulability and thrombosis. The underlying mechanism for PM-related procoagu...

Objectives The Seveso accident caused the contamination of a large inhabited area by 2,3,7,8-tetrachlorodibenzodioxin. Three zones with decreasing soil TCDD levels were delimited: A, B and R. Persons ever living in the contaminated zones and in a surrounding non-contaminated area were followed-up to evaluate long-term effects. The main finding of the mortality (1976–2001) and cancer incidence studies (1977–1991) was an increase in lymphohemopoietic cancers in zones A and B. We report preliminary results of the extension of the follow-up to 30 years after the accident for lymphoemopietic cancers. Methods Incident cases were ascertained through the hospital discharge registration system of the Lombardy region and medical records were reviewed. RR and 95% CI were estimated with Poisson regression techniques controlling for age, gender and calendar period using the non-contaminated area as reference. Results The incidence of all lymphohemopietic cancers was increased in zone A (6 cases, RR =1.2; 95% CI 0.5 to 2.7) and B (47 cases; RR=1.5; 95% CI 1.1 to 2.0). Non-Hodgkin9s lymphomas were modestly increased in zone B, whereas the RR for all leukaemias was 2.0 (95% CI 1.2 to 3.4). 5 cases were lymphatic leukaemia (RR =1.6 95% CI 0.6 to 4.1); 10 myeloid leukaemias showed a RR of 2.1 (95% CI 1.04 to 4.15). All lymphatic leukaemias occurred after 20 years since the accident (RR=4.0; 95% CI 1.4 to 11.6). Myeloid leukaemia did not show a consistent pattern across different categories of time since the accident. Conclusions The extension of the follow-up confirms an increased risk for lymphatic and haemopoietic cancers, particularly leukemia, in the Seveso population.

Background: Particulate Matter (PM) air pollution is critical in Beijing, China, due to very high population density, rapid increase in the number of vehicles, and limited control of industrial emi...

Background and Aims: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undeter...