1. Cystatin C is associated with adverse COVID-19 outcomes in diverse populations
- Author
-
Sam O. Kleeman, Mattia Cordioli, Paul R.H. J. Timmers, Atlas Khan, Pinkus Tober-Lau, Florian Kurth, Vadim Demichev, Hannah V. Meyer, James F. Wilson, Markus Ralser, Krzysztof Kiryluk, Andrea Ganna, Kenneth Baillie, and Tobias Janowitz
- Subjects
Virology ,human metabolism ,Science - Abstract
Summary: COVID-19 has highly variable clinical courses. The search for prognostic host factors for COVID-19 outcome is a priority. We performed logistic regression for ICU admission against a polygenic score (PGS) for Cystatin C (CyC) production in patients with COVID-19. We analyzed the predictive value of longitudinal plasma CyC levels in an independent cohort of patients hospitalized with COVID-19. In four cohorts spanning European and African ancestry populations, we identified a significant association between CyC-production PGS and odds of critical illness (n cases=2,319), with the strongest association captured in the UKB cohort (OR 2.13, 95% CI 1.58-2.87, p=7.12e-7). Plasma proteomics from an independent cohort of hospitalized COVID-19 patients (n cases = 131) demonstrated that CyC production was associated with COVID-specific mortality (p=0.0007). Our findings suggest that CyC may be useful for stratification of patients and it has functional role in the host response to COVID-19.
- Published
- 2022
- Full Text
- View/download PDF