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1. What GDPR and the Health Research Regulations (HRRs) mean for Ireland: 'explicit consent'—a legal analysis

Author

Ann Cullen, Una Gibbons, Elisabeth M Connolly, Emma Halpin, Eoin F. Gaffney, Kathleen Bennett, Ciaran Flanagan, Laura Tier, Aoife Tanaka, Noel G. McElvaney, Lino Manaloto, Blanaid Mee, Sarah A. McGarrigle, Richard Flavin, Niamh Clarke, and Mary Kirwan

Subjects
Male, Biomedical Research, Common law, Legislation, Irish health regulations, 0603 philosophy, ethics and religion, Explicit consent, Health research, 03 medical and health sciences, 0302 clinical medicine, Irish, Informed consent, Health care, Medicine, Data Protection Act 1998, Humans, 030212 general & internal medicine, GDPR, Computer Security, Informed Consent, business.industry, Research, 06 humanities and the arts, General Medicine, language.human_language, Consent declaration, Research Design, Law, General Data Protection Regulation, Legal opinion, language, Government Regulation, Original Article, Female, 060301 applied ethics, business, Ireland
Abstract

Background Irish Health Research Regulations (HRRs) were introduced following the commencement of the General Data Protection Regulation (GDPR) in 2018. The HRRs set out supplementary regulatory requirements for research. A legal analysis presented under the auspices of the Irish Academy of Medical Sciences (IAMS) on April 8 and November 25, 2019 at the Royal College of Surgeons in Ireland welcomed the introduction of GDPR and the HRRs. The analysis found the GDPR “explicit consent” introduced by the HRRs is problematic. A call was made to regulate informed consent in line with the common law as an achievable alternative safeguard, bringing Ireland in line with other EU Member States. Aims This article aims to review academic papers, legal opinion, EU opinion and advice and data protection law in relation to research and explicit consent, in order to examine the legal burden of GDPR and the HRRs on health research in Ireland and to determine whether the analysis presented at the IAMS meetings is reflected more widely in legal text. Methods Legal literature review of academic papers, legal opinion, EU opinion and advice and data protection legislation. Results The legal literature review overwhelmingly supports the concerns raised. Conclusions Our results confirm the GDPR explicit consent requirement of the HRRs is having had a significantly negative and far-reaching impact on the conduct of health research in Ireland. Urgent review of the HRRs and meaningful engagement between the health research community and legislators in healthcare is required.

Published
2020

2. What GDPR and the Health Research Regulations (HRRs) mean for Ireland: a research perspective

Author

Emma Halpin, Aoife Tanaka, Mary Kirwan, Ann Cullen, Lino Manaloto, Eoin F. Gaffney, Kathleen Bennett, Ciaran Flanagan, Laura Tier, Blanaid Mee, Noel G. McElvaney, Sarah A. McGarrigle, Una Gibbons, Elisabeth M Connolly, Richard Flavin, and Niamh Clarke

Subjects
Male, Biomedical Research, Hospital setting, Irish Health Research Regulation, Consent, Irish, media_common.cataloged_instance, Data Protection Act 1998, Medicine, Humans, European union, GDPR, Computer Security, media_common, Retrospective Studies, Data protection, Medical education, business.industry, Corporate governance, Perspective (graphical), General Medicine, language.human_language, Patient recruitment, Research Design, General Data Protection Regulation, Patients & Data protection, language, Government Regulation, Female, Original Article, business, Ireland
Abstract

Background Irish Health Research Regulations (HRRs) were introduced following the European Union (EU) General Data Protection Regulation (GDPR) in 2018. The HRRs described specific supplementary regulatory requirements for research regarding governance, processes and procedure that impact on several facets of research. The numerous problems that the HRRs and particularly “explicit consent” inadvertently created were presented under the auspices of the Irish Academy of Medical Sciences (IAMS) on November 25, 2019, at the Royal College of Surgeons in Ireland. Aims The objective of this review was to obtain feedback and to examine the impact of GDPR and the HRRs on health research in Ireland in order to determine whether the preliminary feedback, presented at the IAMS meetings, was reflected at a national level. Methods Individuals from the research community were invited to provide feedback on the impact, if any, of the HRRs on health research. Retrospective patient recruitment and consent outside a hospital setting for a multi-institutional Breast Predict study (funded by the Irish Cancer Society) were also analysed. Results Feedback replicated the issues presented at the IAMS with additional concerns identified. Only 20% of the original target population (n = 1987) could be included in the Breast Predict study. Conclusions Our results confirm that the HRRs have had a significantly negative impact on health research in Ireland. Urgent meaningful engagement between patient advocate groups, the research community and legislators would help ameliorate these impacts.

Published
2020

4. Irish association for cancer research: Proceedings of Annual Scientific Meeting, University College, Cork, 30th–31st March, 1990.

Author

Moriarty, M., Maher, M., Morton, G., Flavin, A., Mooney, E., Neilan, J., Nestor, P., Horgan, P. G., Kerin, M., Waldron, D., Gannon, F., Given, H., McCann, A. H., Dervan, P. A., Codd, M. B., Guillick, W. J., Carney, D. N., Horgan, P. G., O’Brien, D. P., Waldron, D. J., Mooney, E., McGuire, M., Given, H. F., Dolan, Jane, O’Hora, A., Droogan, Olivia, Curran, Bernadette, Henry, K., Leader, Mary, Meehan, S., Magee, H., Carney, D., Dervan, P., Lawler, M., McCann, S. R., Humphries, P., Barrett, J., O’Sullivan, G., Collins, J. K., Williams, N., Daly, J., Herlyn, M., Corbally, N., Sweeney, E., Dervan, P., Carney, D. N., Sheppard, M. N., Hamid, Q., Corrin, B., Weedle, Roisin M., Cotter, T. G., Wilkinson, Y. A., McKenna, P. G., Hahnvajanawong, C., O’Sullivan, G., McCarthy, M., Collins, J. K., Atkinson, R. J., Pedlow, P., McQuaid, S., Johnson, P., Stuart, J., O’Meara, A., Russell, S. E. H., White, P. M., Atkinson, R. J., Hickey, G. I., Pomeroy, M., Prosser, E., Barker, F., Casey, M., Carroll, K., O’Kennedy, R., Duffy, G., Fennelly, J. J., Duffy, M. J., Reilly, D., Fennelly, J. J., O’Higgins, N., Rochfort, H., O’Neal, K. L., Hoper, M., Odling-Smee, G. W., Abram, W. P., McKenna, P. G., Mooney, E., Brougham, C., Horgan, P., Waldron, D., O’Brien, D., Kerin, M., Heyden, D. R., Given, H. F., Lanigan, D., McLean, P., Murphy, D., Donovan, M. G., Curran, B., Leader, M., Martin, Angela, Clynes, M., Graham, D., Curran, B., McQuaid, S., Dorman, T., Breathnach, F., Fitzgerald, R. J., Leader, M., O’Meara, A., Lennon, S. V., Martin, S. J., Cotter, T. G., Ryan, L., Kilfeather, S. A., O’Malley, K., Nolan, K. B., Croke, D. T., Helene, C., Browne, P. V., Lawler, M., McCann, S. R., Clarke, E., McCann, S. R., Glynn, J., Cotter, K., Shine, M., Cotter, T., Sweeney, E., Dervan, P., Carney, D. N., McKelvey, V. J., Stefani, L. A. J., McKenna, P. G., Ranjbar, S., Cromie, E., Eason, S., Hannigan, B. M., Corbett, A., O’Sullivan, G., Collins, J. K., O’Brien, F., O’Sullivan, G., Collins, J. K., Carney, D. N., Grogan, L., Leonard, N., Morton, G., Flavin, A., Moriarty, M., Foley-Nolan, D., McCann, A., Carney, D. N., Fennelly, J. J., Jones, Mary, Garrett, C., Pomeroy, Maeve, Brennan, D. P., and Powell, D.

Published
1991
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6. Sylvester o’halloran surgical scientific meeting: Proceedings of meeting held 6th & 7th March 1998 in the Foundation Building, University of Limerick

Author

Relihan, N., McGreal, G., Murray, M., McDermott, E. W., O’Higgins, N. J., Duffy, M. J., McNamara, D. A., Harmey, J., Wang, J. H., Donovan, D., Walsh, T. N., Bouchier-Hayes, D. J., Kay, E., Kelly, J. D., Weir, H. P., Keane, P. F., Johnston, S. R., Williamson, K. E., Hamilton, P. W., McManus, D., Morrin, M., Delaney, P. V., Winter, D. C., Harvey, B. J., Geibel, J. P., O’Sullivan, G. C., Delaney, C. P., Coffey, R., Gorey, T. F., Fitzpatrick, J. M., Fanning, N. F., Kirwan, W., Cotter, T., Bouchier-Hayes, D., Redmond, H. P., McNamara, D. A., Pidgeon, G., Harmey, J., Walsh, T. N., Bouchier-Hayes, D. J., Redmond, H. P., Fennessy, F., Wang, J. H., Kelly, C., Bouchier-Hayes, D., Delaney, C. P., Flavin, R., Coffey, R., Gorey, T. F., Fitzpatrick, J. M., Rasheed, A. M., Wang, J. H., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Lang, E. E., Caldwell, M. T. P., Tanner, W. A., Kiely, P. D., O’Reilly, M., Tierney, S., Barry, M., Delaney, P. V., Drumm, J., Grace, P. A., Gallagher, C. M., Grant, D. C., Connell, P., Barry, M. K., Traynor, O., Hyland, J. M. P., O’Sullivan, M. J., Evoy, D., Redmond, H. P., Kirwan, W. O., Cannon, B., Kenny-Walshe, L., Whelton, M. J., O’Grady, H., O’Neill, S., Grant, D. C., Barry, M. K., Traynor, O., Hyland, J. M., Teh, S. H., O’Ceallaigh, S., O’Donohoe, M. K., Tanner, W. A., Keane, F. B., O’Toole, G. C., Grant, D. C., Barry, M. K., Hyland, J. M. P., Calleary, J., Basso, L., Amjad, S. B., Khan, Z., McMullin, L., Joyce, W. P., Balfe, P. J., Caldwell, M. T., Keane, F. B., Tanner, W. A., Teahan, S., Al-Brekeit, K., Tierney, S., Rasheed, A., Bouchier-Hayes, D., Leahy, A., O’Neill, S., Delaney, C. P., Gorey, T. F., Fitzpatrick, J. M., Cullen, A., O’Keane, C., Fennessy, F., Kelly, C., Bouchier-Hayes, D., Fennessy, F., Wang, J. H., Kelly, C., Bouchier-Hayes, D. J., Winter, D. C., MacFarlane, J., Harvey, B. J., O’Sullivan, G. C., Walsh, M., McGloughlin, T., Grace, P., Colgan, D., Madhavan, P., Sultan, S., Colgan, M. P., Moore, D., Shanik, G., McEniff, N., Molloy, M., Eguare, E., Fiuza, C., Grace, P., Burke, P., Maher, R., Creamer, M., Cronin, C. J., Sigurdsso, H. H., Kim, W., Linklater, G., Cross, K. S., Simpson, W. G., Shaw, J. A. M., Pearson, D. W. M., Fitzgerald, P., Quinn, P., Tierney, S., Bouchier-Hayes, D., Brady, C. M., Shah, S. M. A., Ehtisham, M., Khan, M. S., Flood, H. D., Loubani, M., Sweeney, K., Lenehan, B., Lynch, V., Joy, A., McGreal, G., Reidy, D., Mahalingam, K., Cashman, W., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., O’Halloran, D., McGreal, G., McDermott, E. W., O’Higgins, N. J., Neary, P., Hamilton, D., Haider, N., Aherne, N., Watson, R. G. K., Walsh, D., Murphy, M., Joyce, M., Johnston, S., Clinton, O., Given, H. F., Brannigan, A., O’Donohoe, M., Donohoe, J., Corrigan, T., Bresnihan, M., O’Donohoe, M. K., Feeley, T. M., Sultan, S., Madhavan, P., Colgan, M. P., Moore, D., Shanik, G., McMonagle, M. P., Quinlan, D., Kelly, D., Hegarty, P. K., Tan, B., Cronin, C., Brady, M. P., Zeeshan, M., McAvinchey, D. J., Aherne, N., Mooney, C., Coyle, D., Haider, N., Hamilton, D., Neary, P., Watson, R. G. K., Khayyat, G., Masterson, E., Thambi-Pillai, T., Farah, K., Delaney, C. P., Codd, M. B., Fitzpatrick, J. M., Gorey, T. F., Barry, M. K., Tsiotos, G. G., Johnson, C. D., Sarr, M. G., Kell, M. R., Lynch, M., Ryan, D., O’Donovan, A., Winter, D. C., Redmond, H. P., Delaney, C. P., Cassidy, M., Doyle, M., Fulton, G., O’Connell, P. R., Kingston, R., Dillon, M., Barry, M., Tierney, S., Grace, P. A., McGreal, G., Lenehan, B., Murray, M., McDermott, E., O’Higgins, N., Kell, M. R., O’Sullivan, R. G., Tan, B., and O’Donnell, J. A.

Published
1998
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7. Royal Academy of Medicine in Ireland Section of Biomedical Sciences

Author

Ruddock, W., Burns, D. M., Brown, J. C. W., Allen, J. M., Hirst, D. G., Love, G. P., Keenan, A. K., Lally, C., Bird, A., Ryan, M. P., O’Connor, N., O’Boyle, K. M., McGeown, J. G., McCarron, J. G., Drummond, R. M., Fay, F. S., Connor, T. J., Kelly, J. P., Leonard, B. E., Gilmartin, L., O’Cuinn, G., MacDonncha, C., Watson, A. W. S., McGrath, S., Brady, K. J., McKillen, H-C., Taylor, C. W., Smith, S. K., Thornton, S., Martin, A. D., Bailie, J. R., McKeown, S. R., Higgins, C. A., Hatton, W. J., McKerr, G., Harvey, D., Carson, J., Hannigan, B. M., Morrow, D. M. P., McGlynn, H., Thompson, C. M. G., Higgins, C., Galligan, E. S., Murray, M. M., Leckey, J. L., Nevin, G. B., Soppitt, D. S., Esfandiary, M. H., Gilmore, W. S., Robson, T., Dineen, T., Greer, A., Houghton, J. A., O’Halloran, K. D., Bradford, A., McGuire, M., MacDermott, M., Coogan, A., O’Connor, J. J., Regan, C. S., Redmond, A. M., Harkin, A., Lowe, A. S., Baxter, G. D., Kennovin, G. D., Leek, M., Friery, O. P., Hejmadi, M. V., Patterson, L. H., Robinson, J., Hill, I., Kilbride, J., Cotton, K. D., Hollywood, M. A., McHale, N. G., Thornbury, K. D., Halligan, C. P., O’Connell, D. P., Harvey, B. J., Fanning, P., O’Farrell, A., Cantillon, D., Cryan, J. F., O’Leary, D., O’Malley, D. T., Nolan, A., Moran, A. P., Fitzgerald, K. A., O’Neill, L. A. J., McElligott, A., Baker, A. H., Joyce, K. M., Ruane, T., Hall, W. J., Markos, F., Carey, M. F., Galvin, C., Perl, E. R., Curran, A. K., Connolly, C., Abdullah, K., Docherty, J. R., Gavin, K. T., Browne, M., Frazer, C-A., Walsh, D. M., Atkinson, S., Brown, D., O’Connor, J. M., Wasson, G. R., Bonham, M. P., McKelvey-Martin, V. J., Strain, J. J., Downes, C. S., Dineen, T. M., Powell, R., Van Hemelrijk, B., Abujaffom, T. Mubarak, Caulfield, B., Garrett, M., Brennan, L., Griffin, M. J., McShane, A. J., Convery, P. N., Milligan, K. R., Quinn, P., Scott, K., Fee, J. P. H., Cashman, M., Dunne, A., Healy, E., Walsh, J., Watson, A. J., Walsh, D. M., Noble, G., Baxter, G. D., Allen, J. M., Campion, D. P., Leek, B. F., Ryan, J. P., Quinn, T., Dumbleton, M., Smith, K. M., McGrath, J. C., Macmillan, J. B., Doherty, L., Lynch, F., Sweeney, M., O’Regan, R. G., McLoughlin, P., Padua, R. A., Dudeney, S., O’Byrne, J., Moran, R., O’Kelly, K. U., McCormack, B. A. O., Lyons, C. G., Brady, C. L., Simms, C., Maher, S., Schreiber, B., Taylor, D., Carr, A. J., Higgins, B., Dempsey, G. J., Imam, S. Z., Harbinson, M., Adgey, A. A. J., Anderson, J., Aodha, S. Ní, Wilcox, D., Rice, J., Jenkinson, A., O’Rourke, K., O’Brien, T., Devitt, A., McCormack, D., Ikadi, Y., Quinlan, W., Noelke, L., McMahon, G. T., Mulville, J. P., Lee, T. C., Rizvi, A., Fitzpatrick, D., McCarthy, M. A., McGloughlin, T., Monaghan, J., Shine, J., Arendt, E., Lew, B., Lewis, J., Kelly, P. A., Lennon, A. B., Hill, R. G., Dunne, N. J., Thompson, C., Orr, J. F., Beverland, D. E., Prenderville, T., Prendergast, P. J., Huiskes, R., Søballe, K., Mukunda, M. C., Kelly, C. J., Cregg, N., Leahy, A., Dwyer, R., Watson, R. G. K., Bouchier-Hayes, D. J., O’Boyle, C. J., Murchan, P., Mitchell, C. J., Macfie, J., Delicata, R. J., Davies, E. V., Lloyds, D., Petitt, E. J., Carey, P. D., Buckley, D. J., Riordain, M. G. O., Barry, T., Gorey, T. F., Fitzpatrick, J. M., Rothwell, J., Flaherty, J., Wilson, G., Walsh, T. N., Hennessy, T. P. J., O’Donoghue, J., Panchal, J., Mehdi, S., O’Sullivan, S. T., O’Shaughnessy, M., O’Connor, T. P. F., Cox, M. A., Dingle, J. T., Flavin, B. M., Regan, M. C., and O’Connell, P. R.

Published
1997
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8. Biclonal lymphoproliferative disorders: another association with NOTCH1-mutated chronic lymphocytic leukaemias

Author

Helen, Fogarty, Anita, Dowling, David, O'Brien, Steve, Langabeer, Christopher Laurence, Bacon, Richard, Flavin, Michael, O'Dwyer, Brian, Hennessy, Hilary, O'Leary, Gerard, Crotty, Robert, Henderson, James, Nolan, Patrick, Thornton, Elisabeth, Vandenberghe, and Fiona, Quinn

Subjects
Cohort Studies, Mutation, Humans, Lymphoma, Large B-Cell, Diffuse, Receptor, Notch1, Leukemia, Lymphocytic, Chronic, B-Cell
Abstract

Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short disease-free interval and increased risk of Richter's transformation. We hypothesised that the incidence of NOTCH1 mutations in CLL with a second LPD may be increased, because the mutation occurs early in leukaemogenesis, permitting clonal divergence.We identified 19 patients with biclonal LPD at diagnosis: 11 with CLL and a second LPD (group A) and 8 with a second distinct CLL (group B). NOTCH1 mutation analysis was performed and clinical outcome investigated.Ten of 19 (52%) were NOTCH1 mutated: 5 in group A (45%) and 5 in group B (62.5%) with a favourable clinical outcome observed among this cohort with 28.7 (range 1-99) months of follow-up.In conclusion, we identified a significant (52%) incidence of NOTCH1 mutations in CLL in the context of biclonal LPD, associated with an indolent clinical course.

Published
2019

9. Biclonal lymphoproliferative disorders: another association with NOTCH1-mutated chronic lymphocytic leukaemias.

Author

Fogarty, Helen, Dowling, Anita, O'Brien, David, Langabeer, Steve, Bacon, Christopher Laurence, Flavin, Richard, O'Dwyer, Michael, Hennessy, Brian, O'Leary, Hilary, Crotty, Gerard, Henderson, Robert, Nolan, James, Thornton, Patrick, Vandenberghe, Elisabeth, and Quinn, Fiona

Abstract

Introduction: Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short disease-free interval and increased risk of Richter's transformation. We hypothesised that the incidence of NOTCH1 mutations in CLL with a second LPD may be increased, because the mutation occurs early in leukaemogenesis, permitting clonal divergence. Methods: We identified 19 patients with biclonal LPD at diagnosis: 11 with CLL and a second LPD (group A) and 8 with a second distinct CLL (group B). NOTCH1 mutation analysis was performed and clinical outcome investigated. Results: Ten of 19 (52%) were NOTCH1 mutated: 5 in group A (45%) and 5 in group B (62.5%) with a favourable clinical outcome observed among this cohort with 28.7 (range 1–99) months of follow-up. Conclusion: In conclusion, we identified a significant (52%) incidence of NOTCH1 mutations in CLL in the context of biclonal LPD, associated with an indolent clinical course. [ABSTRACT FROM AUTHOR]

Published
2021
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10. What GDPR and the Health Research Regulations (HRRs) mean for Ireland: "explicit consent"—a legal analysis.

Author

Kirwan, Mary, Mee, Blanaid, Clarke, Niamh, Tanaka, Aoife, Manaloto, Lino, Halpin, Emma, Gibbons, Una, Cullen, Ann, McGarrigle, Sarah, Connolly, Elisabeth M., Bennett, Kathleen, Gaffney, Eoin, Flanagan, Ciaran, Tier, Laura, Flavin, Richard, and McElvaney, Noel G.

Abstract

Background: Irish Health Research Regulations (HRRs) were introduced following the commencement of the General Data Protection Regulation (GDPR) in 2018. The HRRs set out supplementary regulatory requirements for research. A legal analysis presented under the auspices of the Irish Academy of Medical Sciences (IAMS) on April 8 and November 25, 2019 at the Royal College of Surgeons in Ireland welcomed the introduction of GDPR and the HRRs. The analysis found the GDPR "explicit consent" introduced by the HRRs is problematic. A call was made to regulate informed consent in line with the common law as an achievable alternative safeguard, bringing Ireland in line with other EU Member States. Aims: This article aims to review academic papers, legal opinion, EU opinion and advice and data protection law in relation to research and explicit consent, in order to examine the legal burden of GDPR and the HRRs on health research in Ireland and to determine whether the analysis presented at the IAMS meetings is reflected more widely in legal text. Methods: Legal literature review of academic papers, legal opinion, EU opinion and advice and data protection legislation. Results: The legal literature review overwhelmingly supports the concerns raised. Conclusions: Our results confirm the GDPR explicit consent requirement of the HRRs is having had a significantly negative and far-reaching impact on the conduct of health research in Ireland. Urgent review of the HRRs and meaningful engagement between the health research community and legislators in healthcare is required. [ABSTRACT FROM AUTHOR]

Published
2021
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11. What GDPR and the Health Research Regulations (HRRs) mean for Ireland: a research perspective.

Author

Mee, Blanaid, Kirwan, Mary, Clarke, Niamh, Tanaka, Aoife, Manaloto, Lino, Halpin, Emma, Gibbons, Una, Cullen, Ann, McGarrigle, Sarah, Connolly, Elisabeth M, Bennett, Kathleen, Gaffney, Eoin, Flanagan, Ciaran, Tier, Laura, Flavin, Richard, and McElvaney, Noel G.

Abstract

Background: Irish Health Research Regulations (HRRs) were introduced following the European Union (EU) General Data Protection Regulation (GDPR) in 2018. The HRRs described specific supplementary regulatory requirements for research regarding governance, processes and procedure that impact on several facets of research. The numerous problems that the HRRs and particularly "explicit consent" inadvertently created were presented under the auspices of the Irish Academy of Medical Sciences (IAMS) on November 25, 2019, at the Royal College of Surgeons in Ireland. Aims: The objective of this review was to obtain feedback and to examine the impact of GDPR and the HRRs on health research in Ireland in order to determine whether the preliminary feedback, presented at the IAMS meetings, was reflected at a national level. Methods: Individuals from the research community were invited to provide feedback on the impact, if any, of the HRRs on health research. Retrospective patient recruitment and consent outside a hospital setting for a multi-institutional Breast Predict study (funded by the Irish Cancer Society) were also analysed. Results: Feedback replicated the issues presented at the IAMS with additional concerns identified. Only 20% of the original target population (n = 1987) could be included in the Breast Predict study. Conclusions: Our results confirm that the HRRs have had a significantly negative impact on health research in Ireland. Urgent meaningful engagement between patient advocate groups, the research community and legislators would help ameliorate these impacts. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
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12. Sylvester o’halloran surgical scientific meeting

Author

N. Relihan, G. McGreal, M. Murray, E. W. McDermott, N. J. O’Higgins, M. J. Duffy, D. A. McNamara, J. Harmey, J. H. Wang, D. Donovan, T. N. Walsh, D. J. Bouchier-Hayes, E. Kay, J. D. Kelly, H. P. Weir, P. F. Keane, S. R. Johnston, K. E. Williamson, P. W. Hamilton, D. McManus, M. Morrin, P. V. Delaney, D. C. Winter, B. J. Harvey, J. P. Geibel, G. C. O’Sullivan, C. P. Delaney, R. Coffey, T. F. Gorey, J. M. Fitzpatrick, N. F. Fanning, W. Kirwan, T. Cotter, D. Bouchier-Hayes, H. P. Redmond, G. Pidgeon, F. Fennessy, C. Kelly, R. Flavin, A. M. Rasheed, A. Leahy, E. E. Lang, M. T. P. Caldwell, W. A. Tanner, P. D. Kiely, M. O’Reilly, S. Tierney, M. Barry, J. Drumm, P. A. Grace, C. M. Gallagher, D. C. Grant, P. Connell, M. K. Barry, O. Traynor, J. M. P. Hyland, M. J. O’Sullivan, D. Evoy, W. O. Kirwan, B. Cannon, L. Kenny-Walshe, M. J. Whelton, H. O’Grady, S. O’Neill, J. M. Hyland, S. H. Teh, S. O’Ceallaigh, M. K. O’Donohoe, F. B. Keane, G. C. O’Toole, J. Calleary, L. Basso, S. B. Amjad, Z. Khan, L. McMullin, W. P. Joyce, P. J. Balfe, M. T. Caldwell, S. Teahan, K. Al-Brekeit, A. Rasheed, A. Cullen, C. O’Keane, J. MacFarlane, M. Walsh, T. McGloughlin, P. Grace, D. Colgan, P. Madhavan, S. Sultan, M. P. Colgan, D. Moore, G. Shanik, N. McEniff, M. Molloy, E. Eguare, C. Fiuza, P. Burke, R. Maher, M. Creamer, C. J. Cronin, H. H. Sigurdsso, W. Kim, G. Linklater, K. S. Cross, W. G. Simpson, J. A. M. Shaw, D. W. M. Pearson, P. Fitzgerald, P. Quinn, C. M. Brady, S. M. A. Shah, M. Ehtisham, M. S. Khan, H. D. Flood, M. Loubani, K. Sweeney, B. Lenehan, V. Lynch, A. Joy, D. Reidy, K. Mahalingam, W. Cashman, E. D. Mulligan, T. Purcell, B. Dunne, M. Griffin, N. Noonan, D. Hollywood, N. Keeling, J. V. Reynolds, T. P. J. Hennessy, D. O’Halloran, P. Neary, D. Hamilton, N. Haider, N. Aherne, R. G. K. Watson, D. Walsh, M. Murphy, M. Joyce, S. Johnston, O. Clinton, H. F. Given, A. Brannigan, M. O’Donohoe, J. Donohoe, T. Corrigan, M. Bresnihan, T. M. Feeley, M. P. McMonagle, D. Quinlan, D. Kelly, P. K. Hegarty, B. Tan, C. Cronin, M. P. Brady, M. Zeeshan, D. J. McAvinchey, C. Mooney, D. Coyle, G. Khayyat, E. Masterson, T. Thambi-Pillai, K. Farah, M. B. Codd, G. G. Tsiotos, C. D. Johnson, M. G. Sarr, M. R. Kell, M. Lynch, D. Ryan, A. O’Donovan, M. Cassidy, M. Doyle, G. Fulton, P. R. O’Connell, R. Kingston, M. Dillon, E. McDermott, N. O’Higgins, R. G. O’Sullivan, and J. A. O’Donnell

Subjects
business.industry, Foundation (engineering), Medicine, Library science, General Medicine, business
Published
1998
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13. Royal Academy of Medicine in Ireland Section of Biomedical Sciences

Author

Kathy M. O'Boyle, Andrew Harkin, B. F. Leek, Peter McLoughlin, R. A. Padua, M. Leek, M. Garrett, A. Watson, C. G. Lyons, C. S. Downes, D. Cantillon, B. A. O. McCormack, P. Quinn, Alan Carr, Margaret Griffin, Thomas F. Gorey, T. Ruane, John J. O'Connor, D. J. Wilcox, T. M. Dineen, P. N. Convery, G. O’Cuinn, Damian P. O’Connell, C-A. Frazer, S. Thornton, Jmcc Anderson, D. M. P. Morrow, K. Scott, D. M. Walsh, O. P. Friery, W. Quinlan, D. M. Burns, J. R. Docherty, C. P. Halligan, Jacqueline M. O'Connor, R. Moran, Edward R. Perl, J. P. Ryan, D. Harvey, F. S. Fay, C. Higgins, T. J. Connor, E. Arendt, R. M. Drummond, Brian E. Leonard, D. Fitzpatrick, L. A. J. O’Neill, P. R. O'Connell, E. S. Galligan, P. M. Murchan, A. Rizvi, R. J. Delicata, K. Søballe, Momna Hejmadi, D. G. Hirst, A. S. Lowe, D. P. Campion, S. Dudeney, T. Robson, John F. Cryan, C. L. Brady, D. S. Soppitt, Brian J. Harvey, B. Schreiber, G. J. Dempsey, Valerie J. McKelvey-Martin, Deborah A. Brown, C. Lally, J. C. McGrath, I. Hill, C. M. G. Thompson, S. Mehdi, P. D. Carey, C. J. O’Boyle, A. Greer, M. H. Esfandiary, T. Quinn, J. R. Bailie, T. P. J. Hennessy, K. R. Milligan, T. Dineen, M. M. Murray, F. Lynch, M. Dumbleton, K. A. Fitzgerald, M. McCarthy, Anthony William Sharpe Watson, John P. Kelly, James Allen, J. Carson, Noel G. McHale, A. M. Redmond, A. Dunne, Austin Leahy, K. Abdullah, Timothy M. McGloughlin, M. C. Mukunda, D. E. Beverland, A. K. Keenan, A. O’Farrell, A. Nolan, G. B. Nevin, Alex Lennon, John Orr, James A. Robinson, J. B. Macmillan, T. N. Walsh, Kevin M. Joyce, J. P. Mulville, S. Maher, K. T. Gavin, Stephanie R. McKeown, R. Powell, J. O’Byrne, David Bouchier-Hayes, S. T. O’Sullivan, L. Brennan, Nicholas Dunne, S. K. Smith, M MacDermott, C. Simms, M. Cashman, K. O’Rourke, Ken D. O'Halloran, C. Thompson, B. M. Flavin, Dervla O'Malley, D. Lloyds, G. Wilson, T. P. F. O’Connor, A. Devitt, S. Ní Aodha, M. G. O. Riordain, N. O’Connor, M. O’Shaughnessy, Patrick J. Prendergast, G. R. Wasson, A. Jenkinson, Bernadette M. Hannigan, B. Higgins, J. J. Strain, E. V. Davies, K. J. Brady, R. G. O’Regan, J. T. Dingle, J. Panchal, J. Rice, J. Rothwell, Michael Carey, Michelle K. McGuire, L. Noelke, Aidan Bradford, A. J. McShane, J. M. O’Donoghue, A. K. Curran, L. Doherty, P. A. Kelly, R. Dwyer, James A. Houghton, G. D. Kennovin, Deirdre M O'Leary, William S. Gilmore, Tim O'Brien, B. Van Hemelrijk, Brian Caulfield, P. Fanning, M. Sweeney, B. Lew, T. Mubarak Abujaffom, J. G. McCarron, K. D. Cotton, S McGrath, J. G. McGeown, J. C. W. Brown, A. P. Moran, K. U. O’Kelly, E. Healy, Keith D. Thornbury, G. D. Baxter, D. McCormack, C. Galvin, L. Gilmartin, Maxine P. Bonham, M. Harbinson, C. Connolly, Y. Ikadi, C. S. Regan, G. Noble, J. Shine, C. J. Kelly, S. Z. Imam, H-C. McKillen, J. Macfie, M. C. Regan, E. J. Petitt, A. A. J. Adgey, Andrew N. Coogan, R. G. K. Watson, Mark A. Hollywood, J. L. Leckey, W. J. Hatton, T. Barry, M. Browne, C. J. Mitchell, S. Atkinson, M. P. Ryan, J. Monaghan, G. T. McMahon, M. A. Cox, G. P. Love, C. A. Higgins, A. H. Baker, N. Cregg, G. McKerr, A. McElligott, Laurence H. Patterson, Ciaran MacDonncha, F. Markos, W. Ruddock, R. Huiskes, A. Bird, J. P. H. Fee, W. J. Hall, J. Kilbride, Hugh McGlynn, C. W. Taylor, David Taylor, D. J. Buckley, J. Flaherty, T. Prenderville, Robert G. Hill, T. C. Lee, Jennifer M. Walsh, K. M. Smith, J. Lewis, A. D. Martin, and John M. Fitzpatrick

Subjects
medicine.medical_specialty, business.industry, Duchenne muscular dystrophy, Section (typography), General Medicine, medicine.disease, Transcutaneous electrical nerve stimulation, Epsp amplitude, law.invention, law, Ophthalmology, medicine, Optometry, business, Biomedical sciences
Published
1997
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14. Irish association for cancer research

Author

M. Moriarty, M. Maher, G. Morton, A. Flavin, E. Mooney, J. Neilan, P. Nestor, P. G. Horgan, M. Kerin, D. Waldron, F. Gannon, H. Given, A. H. McCann, P. A. Dervan, M. B. Codd, W. J. Guillick, D. N. Carney, D. P. O’Brien, D. J. Waldron, M. McGuire, H. F. Given, Jane Dolan, A. O’Hora, Olivia Droogan, Bernadette Curran, K. Henry, Mary Leader, S. Meehan, H. Magee, D. Carney, P. Dervan, M. Lawler, S. R. McCann, P. Humphries, J. Barrett, G. O’Sullivan, J. K. Collins, N. Williams, J. Daly, M. Herlyn, N. Corbally, E. Sweeney, M. N. Sheppard, Q. Hamid, B. Corrin, Roisin M. Weedle, T. G. Cotter, Y. A. Wilkinson, P. G. McKenna, C. Hahnvajanawong, M. McCarthy, R. J. Atkinson, P. Pedlow, S. McQuaid, P. Johnson, J. Stuart, A. O’Meara, S. E. H. Russell, P. M. White, G. I. Hickey, M. Pomeroy, E. Prosser, F. Barker, M. Casey, K. Carroll, R. O’Kennedy, G. Duffy, J. J. Fennelly, M. J. Duffy, D. Reilly, N. O’Higgins, H. Rochfort, K. L. O’Neal, M. Hoper, G. W. Odling-Smee, W. P. Abram, C. Brougham, P. Horgan, D. O’Brien, D. R. Heyden, D. Lanigan, P. McLean, D. Murphy, M. G. Donovan, B. Curran, M. Leader, Angela Martin, M. Clynes, D. Graham, T. Dorman, F. Breathnach, R. J. Fitzgerald, S. V. Lennon, S. J. Martin, L. Ryan, S. A. Kilfeather, K. O’Malley, K. B. Nolan, D. T. Croke, C. Helene, P. V. Browne, E. Clarke, J. Glynn, K. Cotter, M. Shine, T. Cotter, V. J. McKelvey, L. A. J. Stefani, S. Ranjbar, E. Cromie, S. Eason, B. M. Hannigan, A. Corbett, F. O’Brien, L. Grogan, N. Leonard, D. Foley-Nolan, A. McCann, Mary Jones, C. Garrett, Maeve Pomeroy, D. P. Brennan, and D. Powell

Subjects
Irish, business.industry, engineering, language, Library science, Medicine, General Medicine, Cork, engineering.material, business, language.human_language
Published
1991
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15. Transformed follicular lymphoma (tFL): consolidation therapy may improve survival.

Author

Elhassadi, E., Flavin, R., Browne, P., Conneally, E., Hayden, P., Quinn, F., Higgins, E., and Vandenberghe, E.

Abstract

Purpose: Retrospective study to evaluate the outcome of patients with transformed follicular lymphoma (tFL) treated with rituximab-containing chemotherapy and consolidation. Patients and methods: Patients diagnosed with tFL from 2003 to 2013 treated with consolidation therapy with last follow-up in December 2015 were identified from the institutional lymphoma database and included in this study. Data collected included age, gender, stage, interval to tFL diagnosis, R-IPI score, histological diagnosis and therapy. The treatment algorithm used was stratified for age, performance status (PS) and sibling donor availability using R-chemotherapy induction followed by consolidation with allogeneic stem cell transplant (SCT), autologous SCT, Zevalin or rituximab maintenance (RM). Patients with B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt's lymphoma (BCL-U), with FISH-proven t(14;18) and t(8;14) and their variants were excluded. Results: Four hundred patients were diagnosed with FL of whom 26 (7%) developed histologically proven tFL. The group was predominantly male (73%) with a median age at transformation of 53 (range 27-72) years and 85% presented with stage III/IV disease. Thirteen (50%) patients presented with de novo tFL and the remainder had previously diagnosed FL, with a median time to transformation of 5.7 (range 1-15) years. The median follow-up time from tFL diagnosis to December 2015 is 8 (range 4-14) years. All patients received immuno-chemotherapy achieving an overall response rate (ORR) of 100%. Fourteen (54%), patients were transplant eligible and based on donor availability, six had an auto-SCT only, five had an allo-SCT only and three had a matched unrelated allo-SCT for a post-auto-SCT relapse. The 12 patients (46%) who were not transplant eligible were consolidated with rituximab maintenance (RM) in nine (35%) and Zevalin in three (11%) cases. The overall survival (OS) and progression-free survival (PFS) for the series at 5 years were, 92 and 73%, respectively. Conclusion: This consecutively treated series of 26 patients with tFL have had a better outcome than expected which may be due to the use of rituximab-chemotherapy and a consolidation strategy based on age, PS and availability of a sibling donor. [ABSTRACT FROM AUTHOR]

Published
2017
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16. Cannonball metastases with favourable prognosis

Author

Stephen P. Finn, Paul Smyth, James F. Meaney, Eoin F. Gaffney, A. McErlean, J. Kellett, F. O’Connell, Eilis McGovern, and Richard Flavin

Subjects
Oncology, Poor prognosis, medicine.medical_specialty, Lung Neoplasms, Uterine fibroids, Sarcoma, Endometrial Stromal, Endometriosis, Malignancy, Hysterectomy, Diagnosis, Differential, chemistry.chemical_compound, Internal medicine, medicine, Humans, Neoplasm Metastasis, Aged, Lung, Leiomyoma, business.industry, Megestrol Acetate, Sarcoma, General Medicine, respiratory system, medicine.disease, Prognosis, Endometrial Neoplasms, medicine.anatomical_structure, chemistry, Megestrol, Female, business
Abstract

Secondary 'cannonball' metastases to the lung are frequent and usually associated with disseminated malignancy and poor prognosis.To report the case of a patient with metastatic pulmonary endometrial stromal sarcoma who had a previous hysterectomy for benign uterine fibroids and no past history of malignancy.A 70-year-old female presented with cannonball metastases in her lung. Four years previously she had a hysterectomy for 'fibroids'. Review of the original histology revealed endometrial stromal sarcoma, similar to the lung metastasis. She currently has a good prognosis.A patient with 'cannonball' metastases can have a favourable prognosis. A female patient with a previous hysterectomy for uterine fibroids, should be considered to have metastatic sarcoma until proven otherwise.

Published
2005

18. A defect of the urea cycle--a case report

Author

N. O’Brien, E. R. Natighten, and M. P. Flavin

Subjects
Male, Orotic acid, medicine.medical_specialty, business.industry, medicine.medical_treatment, Infant, Newborn, Exchange transfusion, General Medicine, Peritoneal dialysis, Surgery, Ornithine Carbamoyltransferase Deficiency Disease, chemistry.chemical_compound, chemistry, Ammonia, Urea cycle, Anesthesia, medicine, Sodium benzoate, Humans, Urea, business, Amino Acid Metabolism, Inborn Errors, medicine.drug
Abstract

A family is described in which 2 male infants died in the neonatal period. The second infant was found to have a defect of the urea cycle. The diagnosis, treatment and implications for the family are discussed.

Published
1984

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