1. Circulating omega-3 Fatty acids and neovascular age-related macular degeneration
- Author
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Bénédicte M J, Merle, Pascale, Benlian, Nathalie, Puche, Ana, Bassols, Cécile, Delcourt, Eric H, Souied, and Isabelle, Turquois
- Subjects
Male ,medicine.medical_specialty ,Chromatography, Gas ,genetic structures ,Retinal Neovascularization ,Lower risk ,Gastroenterology ,Macular Degeneration ,Fish Oils ,Double-Blind Method ,Internal medicine ,Surveys and Questionnaires ,Fatty Acids, Omega-3 ,medicine ,Oily fish ,Humans ,Aged ,Retrospective Studies ,chemistry.chemical_classification ,business.industry ,Case-control study ,Odds ratio ,Macular degeneration ,medicine.disease ,Eicosapentaenoic acid ,eye diseases ,Treatment Outcome ,chemistry ,Docosahexaenoic acid ,lipids (amino acids, peptides, and proteins) ,Female ,sense organs ,business ,Polyunsaturated fatty acid ,Follow-Up Studies - Abstract
PURPOSE We assessed the associations of serum, red blood cell membranes (RBCM) and dietary long-chain n-3 polyunsaturated fatty acids (LC-PUFAs) with neovascular age-related macular degeneration (AMD). METHODS We included 290 patients of the Nutritional AMD Treatment 2 Study (NAT2) with neovascular AMD in one eye and early AMD lesions in the other eye, and 144 normal vision controls without AMD. Dietary intake of seafood was estimated by food frequency questionnaire. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) composition in serum and RBCM were determined by gas chromatography from 12-hour fasting blood samples and was expressed as percentages of total fatty acids profile. Logistic regressions estimated associations of neovascular AMD with dietary intake of seafood and circulating n-3 LC-PUFAs. RESULTS Dietary oily fish and seafood intake were significantly lower in AMD patients than in controls. After adjustment for all potential confounders (age, sex, CFH Y402H, ARMS2 A69S, and ApoE4 polymorphisms, plasma triglycerides, hypertension, hypercholesterolemia, and family history of AMD), serum EPA was associated significantly with a lower risk for neovascular AMD (odds ratio [OR] = 0.41; 95% confidence interval [CI], 0.22-0.77; P = 0.005). Analysis of RBCM revealed that EPA and EPA+DHA were associated significantly with a lower risk for neovascular AMD (OR = 0.25; 95% CI, 0.13-0.47; P < 0.0001 and OR = 0.52; 95% CI, 0.29-0.94; P = 0.03, respectively). CONCLUSIONS The RBCM EPA and EPA+DHA, as long-term biomarkers of n-3 dietary PUFA status, were associated strongly with neovascular AMD and may represent an objective marker identifying subjects at high risk for neovascular AMD, who may most benefit from nutritional interventions. (http://www.controlled-trials.com/isrctn number, ISRCTN98246501).
- Published
- 2014