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Your search keyword '"Camila Freze Baez"' showing total 2 results
Start Over Author "Camila Freze Baez" Journal intervirology
2 results on '"Camila Freze Baez"'

1. Contents Vol. 57, 2014

Author

Tongjie Chai, Somayeh Jalilvand, Maryam Yousefi, Yoshitake Hayashi, Shohreh Shahmahmoodi, Reza Boroumand, Toshihito Tanahashi, Yuhao Shao, Isolde C. Dapat, Talat Mokhtari-Azad, Carla Maísa Camelini, Kousuke Saito, Laurenza Paradiso, Hiroshi Suzuki, Vincenzo Iervolino, Margherita Giordano, Ali Shoeibi, Abed-Ali Ziaee, Hee-Sup Kim, Satz Mengensatzproduktion, Rosario Ferro, Mahmoud Reza Azarpazhooh, Paulo César Leal, Mireille Lteif, Takako Utsumi, Ali Ghabeli Juibary, Soetjipto, Huijie Ma, Rafael Brandão Varella, Mahin Ahangar Oskouee, Giovanna Loquercio, Seong Min Chung, Arnolfo Petruzziello, Mahmood Mahmoodi, Reiko Saito, Theodor Milidis, Gaetano Di Costanzo, Subarna Roy, Maria Inge Lusida, Anna Maria Diodato, Sahar Darbarpanah, Purushottaman Sugunan Attayur, Yan Yang, Samantha Marigliano, Hassan Zaraket, Hiroki Kondo, Katerina Tsergouli, Zongxi Han, Parvaneh Layegh, Giuseppe Pasquale, Eun Sun Jang, Rosa Azzaro, Silvia Maria Baeta Cavalcanti, Fani Markou, Catia Addolorata Di Macchia, Soha Ghanem, Ageliki Poulou, Nuria Cirauqui Diaz, Francielle Tramontini Gomes de Sousa Cardozo, Xiangang Kong, Young-Sang Byoun, Jadel Müller Kratz, Jing Lv, Rina Okada, Hanggoro Tri Rinonce, Meiling Yao, Pasquale Giuliano, Tingting Zhang, Widya Wasityastuti, Dewiyani Indah Widasari, Tommaso Di Meo, Fei Zhao, Muruganandam Nagarajan, Yaghoob Mollaei-Kandelous, Shengwang Liu, Heidar Ali Esmaeili, Druckerei Stückle, Haimanti Bhattacharya, Ghassan Dbaibo, Jin Wook Kim, Takeshi Azuma, Rong Huang, Rakhshandeh Nategh, Anna Papa, Ricardo José Nunes, Yoshiki Murakami, Karim Nikkhah, Margarida Matos de Mendonça, Clyde Dapat, Sook-Hyang Jeong, John Mallias, Laura Navika Yamani, Ferdinando Russo, Carmela Cacciapuoti, Camila Freze Baez, Rajesh Reesu, Zainab Ali, Samaheh Raftari, Debdutta Bhattacharya, Yoshihiko Yano, Ghazi Kayali, Nicola Coppola, Cláudia Maria Oliveira Simões, and Didik Setyo Heriyanto

Subjects
Infectious Diseases, Virology
Published
2014
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2. Genetic and structural analysis of Merkel cell polyomavirus large T antigen from diverse biological samples

Author

Rafael Brandão Varella, Silvia Maria Baeta Cavalcanti, Nuria Cirauqui Diaz, and Camila Freze Baez

Subjects
Nonsynonymous substitution, Skin Neoplasms, In silico, Antigens, Polyomavirus Transforming, Merkel cell polyomavirus, Single-nucleotide polymorphism, Biology, Molecular Dynamics Simulation, medicine.disease_cause, Pathogenesis, Exon, Virology, medicine, Humans, Computer Simulation, Saliva, Skin, Genetics, Mutation, Base Sequence, Exons, Sequence Analysis, DNA, biology.organism_classification, Protein Structure, Tertiary, Carcinoma, Merkel Cell, Infectious Diseases, medicine.anatomical_structure, Mutant Proteins, Merkel cell
Abstract

Merkel cell polyomavirus (MCPyV) large T antigen (LT-ag) is frequently found truncated in Merkel cell carcinomas (MCC) and it is considered a major tumor-specific signature. Nonetheless, the biological role of LT-ag nontruncated mutations is largely unknown. In this study, MCPyV LT-ag second exon from 11 non-MCC oral samples and NCBI sequences derived from different anatomical sites were studied from the genetic and structural standpoint. As expected, the LT-ag mutation profile was influenced by the geographical origin of the sample, although nonsynonymous mutations were more frequent in lesional tissues. Our in silico study suggests that the mutations found would not significantly affect protein functions, regardless of sample category. This work presents a thorough investigation of the structural and functional properties of LT-ag nontruncated mutations in MCPyV. Our results sustain the geographical influence of the MCPyV genetic profile, but do not discard genetic tissue specificities. Further investigation involving other genetic segments in healthy and lesional tissues are necessary to improve our knowledge on MCPyV pathogenesis.

Published
2013

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