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Start Over Author "Hyo Sin Kim" Journal international urogynecology journal
3 results on '"Hyo Sin Kim"'

1. Changes in urinary nerve growth factor and prostaglandin E2 in women with overactive bladder after anticholinergics

Author

Hyo Sin Kim, Kang Jun Cho, Joon Chul Kim, and Jun Sung Koh

Subjects
Adult, medicine.medical_specialty, medicine.drug_class, Urology, Urinary system, Urinary Bladder, Urination, urologic and male genital diseases, Severity of Illness Index, Cholinergic Antagonists, Dinoprostone, Nerve Growth Factor, Anticholinergic, medicine, Humans, Prostaglandin E2, Aged, Urinary Bladder, Overactive, business.industry, Obstetrics and Gynecology, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Urodynamics, Treatment Outcome, Nerve growth factor, Overactive bladder, Case-Control Studies, Female, lipids (amino acids, peptides, and proteins), sense organs, business, medicine.drug
Abstract

The aim of this study is to investigate changes in urinary nerve growth factor (NGF) and prostaglandin E(2) (PGE(2)) in women with overactive bladder (OAB) following anticholinergic treatment.A total of 30 female patients with OAB were enrolled and the control group included 15 healthy women who did not present any bladder symptoms. All subjects with OAB recorded voiding diaries, underwent urodynamic study, and were evaluated for urgency grade. They received anticholinergic treatment for 4 weeks, after which they were again evaluated for urinary urgency grade and voiding diaries. OAB patients were classified into three groups according to the change on the 5-point Urinary Sensation Scale after the treatment: group 1 (no change in urgency grade), group 2 (1 point of improvement), and, group 3 (more than 2 points of improvement). Urinary NGF and PGE(2) levels between controls and OAB patients (before and after treatment in groups 1, 2, and 3) were compared.Urinary NGF and PGE(2) levels were significantly higher in OAB patients than in the controls. NGF levels were not significantly different between pre- and post-treatment in groups 1 and 2. However, in group 3, NGF levels were significantly decreased after treatment. PGE(2) levels were not significantly different between pre- and post-treatment in either group.NGF and PGE(2) have important roles in the development of OAB symptoms in women. Initial reduction of urgency severity after anticholinergic treatment in women with OAB could be associated with decreasing urinary NGF levels.

Published
2012

2. Comparison of alpha-blocker, extracorporeal magnetic stimulation alone and in combination in the management of female bladder outlet obstruction

Author

Jun Sung Koh, Su Jin Kim, Joon Chul Kim, and Hyo Sin Kim

Subjects
Adult, medicine.medical_specialty, Magnetic Field Therapy, Urology, Treatment outcome, Stimulation, urologic and male genital diseases, Extracorporeal, Bladder outlet obstruction, Combined treatment, Surveys and Questionnaires, Humans, Medicine, Prospective Studies, Adrenergic alpha-Antagonists, business.industry, Obstetrics and Gynecology, Middle Aged, equipment and supplies, Combined Modality Therapy, Urinary Bladder Neck Obstruction, Urodynamics, Treatment Outcome, Quality of Life, Quinazolines, Female, Alpha blocker, business, human activities
Abstract

To determine the effects of alpha-blocker, extracorporeal magnetic innervations (ExMI) alone and combination treatment on female bladder outlet obstruction (BOO).Sixty women with BOO were divided into three groups according to the treatment. After 3 months, the clinical outcomes were evaluated by clinical examination, international prostatic symptom score (IPSS), quality of life (QOL), 3-day voiding diary, uroflowmetry and post-void residual.At 3 months, symptom improvement was 52.6% in alpha-blocker monotherapy (group I), 50.0% in ExMI monotherapy (group II), and 57.1% in combination therapy (group III). Maximum flow rate increased and total IPSS decreased significantly in all groups (p0.05). Storage symptom subscore was more reduced in groups II and III and QOL improved significantly in group III (p0.05)This study demonstrates that both alpha-blocker and ExMI were effective in female BOO, and ExMI may be more effective for improving storage symptoms.

Published
2010

3. Comparison of alpha-blocker, extracorporeal magnetic stimulation alone and in combination in the management of female bladder outlet obstruction.

Author

Jun Sung Koh, Su Jin Kim, Hyo Sin Kim, and Joon Chul Kim

Subjects
MEDICAL research, ADRENERGIC alpha blockers, DRUG efficacy, BLADDER obstruction, DISEASES in women, THERAPEUTICS
Abstract

Introduction and hypothesis: To determine the effects of alpha-blocker, extracorporeal magnetic innervations (ExMI) alone and combination treatment on female bladder outlet obstruction (BOO). Methods: Sixty women with BOO were divided into three groups according to the treatment. After 3 months, the clinical outcomes were evaluated by clinical examination, international prostatic symptom score (IPSS), quality of life (QOL), 3-day voiding diary, uroflowmetry and post-void residual. Results: At 3 months, symptom improvement was 52.6% in alpha-blocker monotherapy (group I), 50.0% in ExMI monotherapy (group II), and 57.1% in combination therapy (group III). Maximum flow rate increased and total IPSS decreased significantly in all groups ( p < 0.05). Storage symptom subscore was more reduced in groups II and III and QOL improved significantly in group III ( p < 0.05) Conclusions: This study demonstrates that both alpha-blocker and ExMI were effective in female BOO, and ExMI may be more effective for improving storage symptoms. [ABSTRACT FROM AUTHOR]

Published
2011
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