1. A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years.
- Author
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Volz, Martin, Schaumburger, Jens, Frick, Hubert, Grifka, Joachim, and Anders, Sven
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CHONDROGENESIS , *CLINICAL trials , *CARTILAGE , *CLINICAL medicine research , *EXTRACELLULAR matrix proteins , *KNEE surgery , *ARTHROPLASTY , *ARTICULAR cartilage , *AUTOGRAFTS , *CARTILAGE diseases , *COMPARATIVE studies , *KNEE , *KNEE diseases , *LONGITUDINAL method , *MAGNETIC resonance imaging , *RESEARCH methodology , *MEDICAL cooperation , *OSTEOARTHRITIS , *RESEARCH , *STATISTICAL sampling , *EVALUATION research , *RANDOMIZED controlled trials , *TREATMENT effectiveness , *REHABILITATION , *SURGERY - Abstract
Purpose: Autologous Matrix-Induced Chondrogenesis (AMIC®) utilizing a type I/III collagen membrane was compared with microfracture (MFx) alone in focal cartilage lesions of the knee at one, two and five years.Methods: Forty-seven patients (aged 37 ± 10 years, mean defect size 3.6 ± 1.6 cm2) were randomized and treated either with MFx, with sutured or glued AMIC® in a prospective multicentre clinical trial.Results: After improvement for the first two years in all subgroups, a progressive and significant score degradation was observed in the MFx group, while all functional parameters remained stable for least five years in the AMIC® groups. At two and five years, MRI defect filling was more complete in the AMIC® groups. No treatment-related adverse events were reported.Conclusions: AMIC® is an effective cartilage repair procedure in the knee resulting in stable clinical results significantly better than the MFx group at five years. [ABSTRACT FROM AUTHOR]- Published
- 2017
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