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Jude-Kennedy C Emejulu1, Igwebuike V Onyiaorah2, Cornelius O Ukah2, Titus OG Chukwuanukwu3, Nneka JF Osuigwe1, Effiong E Akang4, Adefolarin O Malomo51Neurosurgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria; 2Department of Pathology, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria; 3Plastic Surgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria; 4Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria; 5Department of Neurological Surgery, Institute of Neurological Sciences, University College Hospital, Ibadan, Oyo State, NigeriaAbstract: A 36-year-old male painter presented to our service in 2007 with an ulcerated solitary scalp swelling of 8 months’ duration. The mass was a dormant, painless, pea-sized growth, which he had had since childhood and which he bruised in a passenger motorcycle road traffic accident 8 months prior to presentation. The accident caused it to flare up and progressively increase in size, with associated pain, contact bleeding, and ulceration. A work-up for excision biopsy was proposed, but the patient defaulted and presented 2 years later with an increased number of lesions all around the scalp and face and in an obviously deteriorating clinical status with regional lymph node involvement at this stage. An incisional biopsy was then carried out and the histological reports came out with three different diagnoses of glioblastoma multiforme, poorly differentiated angiosarcoma, and squamous cell carcinoma, constituting a major diagnostic dilemma for our service.Keywords: angiosarcoma, glioblastoma multiforme, head, neck, squamous cell carcinoma