1. Comparative Evaluation of Intralesional Triamcinolone Acetonide Injection, Narrow Band Ultraviolet B, and their Combination in Alopecia Areata
- Author
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Sandeep Kaur, Raman Mahajan, and Bharat Bhushan Mahajan
- Subjects
medicine.medical_specialty ,Triamcinolone acetonide ,business.industry ,Alopecia areata ,Ultraviolet b ,Context (language use) ,Dermatology ,Terminal hair ,medicine.disease ,triamcinolone acetonide ,Comparative evaluation ,TRIAMCINOLONE ACETONIDE INJECTION ,Hair loss ,medicine ,Original Article ,narrow band ultraviolet B ,business ,medicine.drug - Abstract
Context: Alopecia areata (AA), an autoimmune disorder, can affect any hair-bearing area. No treatment so far has produced a consistent response. Narrow band ultraviolet B (NBUVB) has not been studied in its management. Aims: Comparative evaluation of intralesional triamcinolone acetonide injection, NBUVB, and their combination in AA. Materials and Methods: Forty patients (28 males and 12 females) with at least three patches of hair loss were enrolled after obtaining written informed consent. Patches were subdivided as follows: Patch 1 was injected with triamcinolone acetonide 2.5 mg/ml (total of three injections) at 3 weeks interval. Patch 2 - NBUVB was given twice a week for a total of 12 weeks. Patch 3 - combination of injection and NBUVB. Therapeutic response was recorded as regrowth of terminal hair (G0 to G4). Statistical Analysis Used: Chi-square test. P < 5% was considered significant. Results: At the end of treatment and follow-up, that is, at week 12, more than 50% of hair regrowth was evident in 27 (67.5%) patients with intralesional steroid; 7 (17.5%) with NBUVB; and 25 (62.5%) patients with their combination. This difference in the clinical response was statistically significant. Conclusions: Intralesional steroid is more effective than NBUVB and their combination is not synergistic in terms of the clinical response in AA.
- Published
- 2015