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Sclerosing rhabdomyosarcoma (RMS) is a rare subtype of RMS with unique prominent stromal hyalinization and a pseudovascular architecture. It overlaps morphologically with spindle cell RMS and poses both diagnostic and therapeutic challenges because of its rarity and aggressive clinical course. In this article, we report a case of sclerosing RMS arising from a prior craniotomy site, which demonstrated both sclerosing and spindle cell components. A literature review of RMS with sclerosing morphology identified 122 cases. Our review documents the following: sclerosing RMS occurs in both childhood and adult populations, has a predilection for the head and neck areas, and has a worse prognosis in adults. Sclerosing RMS harbors a high frequency of MYOD1 mutations, conferring a poor clinical outcome. Sclerosing RMS and spindle RMS likely represent a morphologic spectrum of one entity. [ABSTRACT FROM AUTHOR]

The article presents information on the "International Journal of Surgical Pathology." The reasons why the perception that there are already too many journals soliciting too few manuscripts in the field may not be completely accurate are cited. There has been an increase in the total number of abstracts received by the U.S.-Canadian Division of the International Academy of Pathology. An explanation for this unambiguous rise is provided.