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Start Over Author "Coutinho, Jonathan" Journal international journal of stroke
13 results on '"Coutinho, Jonathan"'

1. Reducing the global burden of cerebral venous thrombosis: An international research agenda

Author

Coutinho, Jonathan M, primary, van de Munckhof, Anita, additional, Aguiar de Sousa, Diana, additional, Poli, Sven, additional, Aaron, Sanjith, additional, Arauz, Antonio, additional, Conforto, Adriana B, additional, Krzywicka, Katarzyna, additional, Hiltunen, Sini, additional, Lindgren, Erik, additional, Sánchez van Kammen, Mayte, additional, Shu, Liqi, additional, Bakchoul, Tamam, additional, Belder, Rosalie, additional, van den Berg, René, additional, Boumans, Elisheva, additional, Cannegieter, Suzanne, additional, Cano-Nigenda, Vanessa, additional, Field, Thalia S, additional, Fragata, Isabel, additional, Heldner, Mirjam R, additional, Hernández-Pérez, María, additional, Klok, Frederikus A, additional, Leker, Ronen R, additional, Lucas-Neto, Lia, additional, Molad, Jeremy, additional, Nguyen, Thanh N, additional, Saaltink, Dirk-Jan, additional, Saposnik, Gustavo, additional, Sharma, Pankaj, additional, Stam, Jan, additional, Thijs, Vincent, additional, van der Vaart, Michiel, additional, Werring, David J, additional, Wong Ramos, Diana, additional, Yaghi, Shadi, additional, Yeşilot, Nilüfer, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Jood, Katarina, additional, Arnold, Marcel, additional, and Ferro, José M, additional

Published
2024
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2. Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries

Author

van de Munckhof, Anita, primary, Borhani-Haghighi, Afshin, additional, Aaron, Sanjith, additional, Krzywicka, Katarzyna, additional, van Kammen, Mayte Sánchez, additional, Cordonnier, Charlotte, additional, Kleinig, Timothy J, additional, Field, Thalia S, additional, Poli, Sven, additional, Lemmens, Robin, additional, Scutelnic, Adrian, additional, Lindgren, Erik, additional, Duan, Jiangang, additional, Arslan, Yıldız, additional, van Gorp, Eric CM, additional, Kremer Hovinga, Johanna A, additional, Günther, Albrecht, additional, Jood, Katarina, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Heldner, Mirjam R, additional, Arnold, Marcel, additional, de Sousa, Diana Aguiar, additional, Wasay, Mohammad, additional, Arauz, Antonio, additional, Conforto, Adriana Bastos, additional, Ferro, José M, additional, Coutinho, Jonathan M, additional, Mbroh, Joshua, additional, Ciccone, Alfonso, additional, Wittstock, Matthias, additional, Zimmermann, Julian, additional, Bode, Felix J, additional, Skjelland, Mona, additional, Dizonno, Vanessa, additional, Devroye, Annemie, additional, Hiltunen, Sini, additional, Petruzzellis, Marco, additional, Bakchoul, Tamam, additional, Levi, Marcel, additional, Middeldorp, Saskia, additional, Sharma, Aarti R, additional, Ghoreishi, Abdoreza, additional, Elkady, Ahmed, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Buture, Alina, additional, Cervera, Alvaro, additional, Paiva Nunes, Ana, additional, Romina Montané Baños, Ana, additional, Tiede, Andreas, additional, Tuladhar, Anil M, additional, Mengel, Annerose, additional, Medina, Antonio, additional, Aujayeb, Avinash, additional, Ramasamy, Balakrishnan, additional, Casolla, Barbara, additional, Spratt, Neil, additional, Ziaadini, Bentolhoda, additional, Varkey Maramattom, Boby, additional, Buck, Brian, additional, Garcia-Esperon, Carlos, additional, Vayne, Caroline, additional, Jacobi, Christian, additional, Pfrepper, Christian, additional, Bal, Deepti, additional, Sergio Zimatore, Domenico, additional, Michalski, Dominik, additional, Blacquiere, Dylan, additional, Johansson, Elias, additional, Cuadrado-Godia, Elisa, additional, Sadeghi-Hokmabadi, Elyar, additional, Carrera, Emmanuel, additional, Maistre, Emmanuel De, additional, Saxhaug Kristoffersen, Espen, additional, Hooshmandi, Etrat, additional, Bonneville, Fabrice, additional, Vuillier, Fabrice, additional, Giammello, Fabrizio, additional, D’Onofrio, Florindo, additional, Tsivgoulis, Georgios, additional, Gulli, Giosue, additional, Katzberg, Hans, additional, Sibon, Igor, additional, Baharoglu, Irem, additional, Masjuan, Jaime, additional, Fernandes, João, additional, Pelz, Johann, additional, Octavio López Esparza, Jorge, additional, Schouten, Judith, additional, Ng, Karl, additional, Derex, Laurent, additional, Puy, Laurent, additional, Poorsaadat, Leila, additional, Valler, Lenise, additional, Januzi de Almeida Rocha, Letícia, additional, Murillo-Bonilla, Luis, additional, Kellermair, Lukas, additional, Morin Martin, Mar, additional, Sofia Cotelli, Maria, additional, Hernandez Perez, Maria, additional, Zedde, Marialuisa, additional, Carvalho Dias, Mariana, additional, Carvalho, Marta, additional, Ghiasian, Masoud, additional, Umaiorubahan, Meenakshisundaram, additional, Roozbeh, Mehrdad, additional, Romoli, Michele, additional, Miranda, Miguel, additional, Wronski, Miriam, additional, Saadatnia, Mohammad, additional, Bandettini di Poggio, Monica, additional, Almasi-Dooghaee, Mostafa, additional, Hoseininejad Mir, Nahid, additional, Ichaporia, Nasli R, additional, Kumar Paramasivan, Naveen, additional, Raposo, Nicolas, additional, Fadakar, Nima, additional, Kruyt, Nyika, additional, Detante, Olivier, additional, Sharma, Pankaj, additional, Candelaresi, Paolo, additional, Scoppettuolo, Pasquale, additional, Reiner, Peggy, additional, Sylaja, PN, additional, Kumar Karunakaran, Ravi, additional, Vieira, Ricardo, additional, Kern, Rolf, additional, Goh, Rudy, additional, Erat Sreedharan, Sapna, additional, Murphy, Seán, additional, Timsit, Serge, additional, Coutts, Shelagh, additional, Sharma, Shyam S, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Kaul, Subhash, additional, Karapanayiotides, Theodoros, additional, Gattringer, Thomas, additional, Mathew, Thomas, additional, Bartsch, Thorsten, additional, Palma, Vincenzo, additional, Mirzaasgari, Zahra, additional, Zamani, Zohreh, additional, Mirahmadizadeh, Alireza, additional, Gutierrez-Romero, Alonso, additional, Iván Valdes-Ferrer, Ivan, additional, Elizabeth Ceballos-Liceaga, Santa, additional, and Maria Santibañez-Copado, Ana, additional

Published
2023
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4. The association between computed tomography angiography timing and workflow times in patients with acute ischemic stroke

Author

Dessens, Femke M, primary, Groot, Adrien E, additional, van der Veen, Bas, additional, Treurniet, Kilian M, additional, Majoie, Charles BLM, additional, Driessen-Waaijer, Annet, additional, Weinstein, Henry C, additional, Roos, Yvo BWEM, additional, Van den Berg-Vos, Renske M, additional, Coutinho, Jonathan M, additional, and van Schaik, Sander M, additional

Published
2020
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5. Recanalization after cerebral venous thrombosis. A randomized controlled trial of the safety and efficacy of dabigatran etexilate versus dose-adjusted warfarin in patients with cerebral venous and dural sinus thrombosis.

Author

Ferro, José M, Bendszus, Martin, Jansen, Olav, Coutinho, Jonathan M, Dentali, Francesco, Kobayashi, Adam, Aguiar de Sousa, Diana, Neto, Lia L, Miede, Corinna, Caria, Jorge, Huisman, Holger, and Diener, Hans-Christoph

Subjects
CRANIAL sinuses, CEREBRAL embolism & thrombosis, VENOUS thrombosis, SINUS thrombosis, RANDOMIZED controlled trials
Abstract

Background: The effect of different anticoagulants on recanalization after cerebral venous thrombosis has not been studied in a randomized controlled trial. Methods: RE-SPECT CVT (ClinicalTrials.gov number: NCT02913326) was a Phase III, prospective, randomized, parallel-group, open-label, multicenter, exploratory trial with blinded endpoint adjudication. Acute cerebral venous thrombosis patients were allocated to dabigatran 150 mg twice daily, or dose-adjusted warfarin, for 24 weeks, after 5–15 days' treatment with unfractionated or low-molecular-weight heparin. A standardized magnetic resonance protocol including arterial spin labeling, three-dimensional time-of-flight venography, and three-dimensional contrast-enhanced magnetic resonance angiography was obtained at the end of the treatment period. Cerebral venous recanalization at six months was assessed by two blinded adjudicators, using the difference in a score of occluded sinuses and veins (predefined secondary efficacy endpoint) and in the modified Qureshi scale (additional endpoint), between baseline and the end of the treatment. Results: Of 120 cerebral venous thrombosis patients randomized, venous recanalization could be evaluated in 108 (55 allocated to dabigatran and 53 to warfarin, 1 patient had a missing occlusion score at baseline). No patient worsened in the score of occluded cerebral veins and sinuses, while 33 (60%) on dabigatran and 35 (67%) on warfarin improved. The mean score change from baseline in the occlusion score was similar in the two treatment groups (dabigatran −0.8, SD 0.78; warfarin −1.0, SD 0.92). In the modified Qureshi score, full recanalization was adjudicated in 24 (44%) and 19 (36%), and partial recanalization in 23 (42%) and 26 (49%) patients in the dabigatran and warfarin arms, respectively. No statistically significant treatment difference in the modified Qureshi score could be detected (p = 0.44). Conclusion: The majority of patients with cerebral venous thrombosis, anticoagulated with either dabigatran or warfarin for six months, showed partial or complete recanalization of occluded sinuses and veins at the end of the treatment. Clinical trial registration: Trial registry name: ClinicalTrials.gov URL: https://clinicaltrials.gov Registration number: NCT02913326 [ABSTRACT FROM AUTHOR]

Published
2022
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7. The association between computed tomography angiography timing and workflow times in patients with acute ischemic stroke.

Author

Dessens, Femke M, Groot, Adrien E, van der Veen, Bas, Treurniet, Kilian M, Majoie, Charles BLM, Driessen-Waaijer, Annet, Weinstein, Henry C, Roos, Yvo BWEM, Van den Berg-Vos, Renske M, Coutinho, Jonathan M, and van Schaik, Sander M

Subjects
COMPUTED tomography, STROKE patients, ANGIOGRAPHY, QUANTILE regression
Abstract

Background: In most hospitals, computed tomography angiography (CTA) is nowadays routinely performed in patients with acute ischemic stroke. However, it is unclear whether CTA is best performed before or after start of intravenous thrombolysis (IVT), since acquisition of CTA before IVT may prolong door-to-needle times, while acquisition after IVT may prolong door-to-groin times in patients undergoing endovascular treatment. Methods: We performed a before-versus-after study (CTA following IVT, period I and CTA prior to IVT, period II), consisting of two periods of one year each. This study is based on a prospective registry of consecutive patients treated with IVT in two collaborating high-volume stroke centers; one primary stroke center and one comprehensive stroke center. The primary outcome was door-to-needle times. Secondary outcomes included door-to-groin times. Quantile regression analyses were performed to evaluate the association between timing of CTA and workflow times, adjusted for prognostic factors. Results: A total of 519 patients received IVT during the study period (246 in period I, 273 in period II). In the adjusted analysis, we found a nonsignificant 1.13 min median difference in door-to-needle times (95% confidence interval: 1.03–3.29). Door-to-groin times was significantly shorter in period II in both unadjusted and adjusted analysis with the latter showing a 19.16 min median difference (95% confidence interval: 3.08–35.24). Conclusions: CTA acquisition prior to start of IVT did not adversely affect door-to-needle times. However, a significantly shorter door-to-groin times was observed in endovascular treatment eligible patients. Performing CTA prior to start of IVT seems the preferred strategy. [ABSTRACT FROM AUTHOR]

Published
2021
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8. Rationale, design, and protocol of a randomized controlled trial of the safety and efficacy of dabigatran etexilate versus dose-adjusted warfarin in patients with cerebral venous thrombosis

Author

Ferro, José M, primary, Dentali, Francesco, additional, Coutinho, Jonathan M, additional, Kobayashi, Adam, additional, Caria, Jorge, additional, Desch, Marc, additional, Fraessdorf, Mandy, additional, Huisman, Holger, additional, and Diener, Hans-Christoph, additional

Published
2018
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9. The benefit of EXtending oral antiCOAgulation treatment (EXCOA) after acute cerebral vein thrombosis (CVT): EXCOA-CVT cluster randomized trial protocol

Author

Miranda, Bruno, primary, Aaron, Sanjith, additional, Arauz, Antonio, additional, Barinagarrementeria, Fernando, additional, Borhani-Haghighi, Afshin, additional, Carvalho, Marta, additional, Conforto, Adriana B, additional, Coutinho, Jonathan M, additional, Stam, Jan, additional, Canhão, Patrícia, additional, and Ferro, José M, additional

Published
2018
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10. Thrombolysis related symptomatic intracranial hemorrhage in estimated versus measured body weight.

Author

Truc My Nguyen, T, van de Stadt, Stephanie IW, Groot, Adrien E, Wermer, Marieke JH, den Hertog, Heleen M, Droste, Hanneke M, van Zwet, Erik W, van Schaik, Sander M, Coutinho, Jonathan M, and Kruyt, Nyika D

Subjects
BODY weight, TISSUE plasminogen activator, WEIGHT measurement, THROMBOLYTIC therapy, HEMORRHAGE
Abstract

Background and aim: In acute ischemic stroke, under- or overestimation of body weight can lead to dosing errors of recombinant tissue plasminogen activator with consequent reduced efficacy or increased risk of hemorrhagic complications. Measurement of body weight is more accurate than estimation of body weight but potentially leads to longer door-to-needle times. Our aim was to assess if weight modality (estimation of body weight versus measurement of body weight) is associated with (i) symptomatic intracranial hemorrhage rate, (ii) clinical outcome, and (iii) door-to-needle times. Methods: Consecutive patients treated with intravenous thrombolysis between 2009 and 2016 from 14 hospitals were included. Baseline characteristics and outcome parameters were retrieved from medical records. We defined symptomatic intracranial hemorrhage according to the European Cooperative Acute Stroke Study (ECASS)-III definition and clinical outcome was assessed with the modified Rankin Scale. The association of weight modality and outcome parameters was estimated with regression analyses. Results: A total of 4801 patients were included. Five hospitals used measurement of body weight (n = 1753), six hospitals used estimation of body weight (n = 2325), and three hospitals (n = 723) changed from estimation of body weight to measurement of body weight during the study period. In 2048 of the patients (43%), measurement of body weight was used and in 2753 (57%), estimation of body weight. In the measurement of body weight group, an inbuilt weighing bed was used in 1094 patients (53%) and a patient lift scale in 954 patients (47%). In the estimation of body weight group, policy regarding estimation was similar. Estimation of body weight was not associated with increased symptomatic intracranial hemorrhage risk (adjusted odds ratio = 1.16; 95% confidence interval 0.83–1.62) or favorable outcome (adjusted odds ratio = 0.99; 95% confidence interval 0.82–1.21), but it was significantly associated with longer door-to-needle times compared to measurement of body weight using an inbuilt weighing bed (adjusted B = 3.57; 95% confidence interval 1.33–5.80) and shorter door-to-needle times compared to measurement of body weight using a patient lift scale (−3.96; 95% confidence interval −6.38 to −1.53). Conclusion: We did not find evidence that weight modality (estimation of body weight versus measurement of body weight) to determine recombinant tissue plasminogen activator dose in intravenous thrombolysis eligible patients is associated with symptomatic intracranial hemorrhage or clinical outcome. We did find that estimation of body weight leads to longer door-to-needle times compared to measurement of body weight using an inbuilt weighing bed and to shorter door-to-needle times compared to measurement of body weight using a patient lift scale. [ABSTRACT FROM AUTHOR]

Published
2020
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11. Embolic strokes of undetermined source: Prevalence and patient features in the ESUS Global Registry

Author

Perera, Kanjana S, primary, Vanassche, Thomas, additional, Bosch, Jackie, additional, Giruparajah, Mohana, additional, Swaminathan, Balakumar, additional, Mattina, Katie R, additional, Berkowitz, Scott D, additional, Arauz, Antonio, additional, O’Donnell, Martin J, additional, Ameriso, Sebastian F, additional, Hankey, Graeme J, additional, Yoon, Byung-Woo, additional, Lavallee, Philippa, additional, Cunha, Luis, additional, Shamalov, Nikolay, additional, Brouns, Raf, additional, Gagliardi, Rubens J, additional, Kasner, Scott E, additional, Pieroni, Alessio, additional, Vermehren, Philipp, additional, Kitagawa, Kazuo, additional, Wang, Yongjun, additional, Muir, Keith, additional, Coutinho, Jonathan, additional, Vastagh, Ildiko, additional, Connolly, Stuart J, additional, and Hart, Robert G, additional

Published
2016
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13. Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis: Rationale and Design of the TO-ACT Trial

Author

Coutinho, Jonathan M., primary, Ferro, José M., additional, Zuurbier, Susanna M., additional, Mink, Marieke S., additional, Canhão, Patrícia, additional, Crassard, Isabelle, additional, Majoie, Charles B., additional, Reekers, Jim A., additional, Houdart, Emmanuel, additional, de Haan, Rob J., additional, Bousser, Marie-Germaine, additional, and Stam, Jan, additional

Published
2012
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