1. Effect of 12-wk Training in Ovariectomised Rats on PGC-1α, NRF-1 and Energy Substrates
- Author
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Taciane Maria Melges Pejon, Vinicius Silva Faria, Claudio Alexandre Gobatto, Fúlvia Barros Manchado-Gobatto, Pedro Paulo Menezes Scariot, Anabelle Silva Cornachione, and Wladimir Rafael Beck
- Subjects
Blood Glucose ,Ovariectomy ,Physical Conditioning, Animal ,NF-E2-Related Factor 1 ,Animals ,Female ,Orthopedics and Sports Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Muscle, Skeletal ,Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ,Glycogen ,Triglycerides ,Rats - Abstract
Metabolic diseases are associated with hypoestrogenism owing to their lower energy expenditure and consequent imbalance. Physical training promotes energy expenditure through PGC-1α and NRF-1, which are muscle proteins of the oxidative metabolism. However, the influence of physical training on protein expression in individuals with hypoestrogenism remains uncertain. Thus, the aim of this study is to determine the effect of 12 weeks of moderate-intensity swimming training on the muscle expression of PGC-1α, NRF-1, glycogen and triglyceride in ovariectomised rats. OVX and OVX+TR rats were subjected to ovariectomy. The trained animals swam for 30 minutes, 5 days/week, at 80% of the critical load intensity. Soleus was collected to quantify PGC-1α and NRF-1 expressions, while gastrocnemius and gluteus maximus were collected to measure glycogen and triglyceride. Blood glucose was also evaluated. Whereas ovariectomy decreased PGC-1α expression (p
- Published
- 2022