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• Method to scale the scroll compressor for different cooling capacities and refrigerants. • Validation of scroll compressor model in PDSim. • Performance evaluation of low-GWP refrigerants in scroll compressor. Performance evaluation of low-GWP refrigerants in scroll compressor is carried out to aid the selection of suitable refrigerant for different applications. The open-source modeling platform PDSim, used for this study, is based on the mechanistic chamber model that has the accuracy comparable to the heuristic methods. A scaling model is developed to design and select the scroll geometry for 1–100 ton range of cooling capacity and seven refrigerants. This method is based on manufacturing constraints and minimization of leakage. Additionally, the ports and the bearings are scaled to make their effect fair for a range of capacities and refrigerants. The simulation model is validated using two example scroll compressors. The predicted mass flow rate and power are within 3% MAE while the isentropic efficiency is within 4% mean absolute error. A validated model and standard AHRI conditions are used for the performance evaluation of the refrigerants over a range of 1 to 100 tons of refrigeration capacity. Seven refrigerants are studied including low-pressure refrigerants, R1234ze(E) and R1234yf, medium-pressure refrigerants, R410A, R32, R454B, and R452B and high-pressure R744. The results suggest that an optimum range exists for each refrigerant to achieve good compressor performance. The leakage area is the primary contributor to the scroll compressor performance. [ABSTRACT FROM AUTHOR]