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Your search keyword '"van Leeuwen, Flora E."' showing total 13 results
Start Over Author "van Leeuwen, Flora E." Journal international journal of radiation oncology, biology, physics
13 results on '"van Leeuwen, Flora E."'

2. Breast Cancer Risk After Radiation Therapy for Hodgkin Lymphoma: Influence of Gonadal Hormone Exposure

Author

Krul, Inge M., Opstal–van Winden, Annemieke W.J., Aleman, Berthe M.P., Janus, Cécile P.M., van Eggermond, Anna M., De Bruin, Marie L., Hauptmann, Michael, Krol, Augustinus D.G., Schaapveld, Michael, Broeks, Annegien, Kooijman, Karen R., Fase, Sandra, Lybeert, Marnix L., Zijlstra, Josée M., van der Maazen, Richard W.M., Kesminiene, Ausrele, Diallo, Ibrahima, de Vathaire, Florent, Russell, Nicola S., and van Leeuwen, Flora E.

Published
2017
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12. Cardiotoxic Effects of Tangential Breast Irradiation in Early Breast Cancer Patients: The Role of Irradiated Heart Volume

Author

Borger, Jacques H., Hooning, Maartje J., Boersma, Liesbeth J., Snijders-Keilholz, Antonia, Aleman, Berthe M.P., Lintzen, Eelke, van Brussel, Sara, van der Toorn, Peter-Paul, Alwhouhayb, Maitham, and van Leeuwen, Flora E.

Subjects
*BREAST cancer, *IRRADIATION, *CARDIOVASCULAR diseases, *CANCER radiotherapy
Abstract

Purpose: To assess the risk of cardiovascular disease (CVD) after postlumpectomy irradiation restricted to tangential fields. Methods and Materials: We assessed the incidence of CVD in 1601 patients with T1–2N0 breast cancer (BC) treated with breast tangentials in five different hospitals between 1980 and 1993. Patients treated with radiation fields other than breast tangentials and those treated with adjuvant chemotherapy were excluded. For patients with left-sided BC, maximum heart distance (MHD) was measured on the simulator films as a proxy for irradiated heart volume. Risk of CVD by laterality and MHD categories was evaluated by Cox proportional hazards regression analysis. Results: Follow-up was complete for 94% of the patients, and median follow-up was 16 years. The incidence of CVD overall was 14.1%, of ischemic heart disease 7.3%, and for other types of heart disease 9.2%, with a median time to event of 10 to 11 years. The incidence of CVD was 11.6% in patients with right-sided BC, compared with 16.0% in left-sided cases. The hazard ratio associated with left-sided vs. right-sided BC was 1.38 (95% confidence interval [CI], 1.05–1.81) for CVD overall, 1.35 (95% CI, 0.93–1.98) for ischemic heart disease , and 1.53 (95% CI, 1.09–2.15) for other heart disease, adjusted for age, diabetes, and history of CVD. The risk of CVD did not significantly increase with increasing MHD. Conclusions: Patients irradiated for left-sided BC with tangential fields have a higher incidence of CVD compared with those with right-sided cancer. However, the risk does not seem to increase with larger irradiated heart volumes. [Copyright &y& Elsevier]

Published
2007
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13. Cause-specific mortality in long-term survivors of breast cancer: A 25-year follow-up study

Author

Hooning, Maartje J., Aleman, Berthe M.P., van Rosmalen, Agnes J.M., Kuenen, Marianne A., Klijn, Jan G.M., and van Leeuwen, Flora E.

Subjects
*LUMPECTOMY, *CANCER patients, *CANCER-related mortality, *BREAST cancer surgery, *MEDICAL radiology, *CARDIOVASCULAR diseases
Abstract

Purpose: To assess long-term cause-specific mortality in breast cancer patients. Patients and Methods: We studied mortality in 7425 patients treated for early breast cancer between 1970 and 1986. Follow-up was 94% complete until January 2000. Treatment-specific mortality was evaluated by calculating standardized mortality ratios (SMRs) based on comparison with general population rates and by using Cox proportional hazards regression. Results: After a median follow-up of 13.8 years, 4160 deaths were observed, of which 76% were due to breast cancer. Second malignancies showed a slightly increased SMR of 1.2 (95% confidence interval [CI], 1.0–1.3). Radiotherapy (RT) as compared with surgery was associated with a 1.7-fold (95% CI, 1.2–2.5) increased mortality from cardiovascular disease (CVD). After postlumpectomy RT, no increased mortality from CVD was observed (hazard ratio, 1.0; 95% CI, 0.5–1.9). Postmastectomy RT administered before 1979 and between 1979 and 1986 was associated with a 2-fold (95% CI, 1.2–3.4) and 1.5-fold (95% CI, 0.9–2.7) increase, respectively. Patients treated before age 45 experienced a higher SMR (2.0) for both solid tumors (95% CI, 1.6–2.7) and CVD (95% CI, 1.3–3.1). Conclusion: Currently, a large population of breast cancer survivors is at increased risk of death from CVDs and second cancers, especially when treated with RT at a young age. Patients irradiated after 1979 experience low (postmastectomy RT) or no (postlumpectomy RT) excess mortality from CVD. [Copyright &y& Elsevier]

Published
2006
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