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Your search keyword '"Fokdal, Lars U."' showing total 6 results
Start Over Author "Fokdal, Lars U." Journal international journal of radiation oncology, biology, physics
6 results on '"Fokdal, Lars U."'

1. Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future

Author

Spampinato, Sofia, Jensen, Nina B.K., Pötter, Richard, Fokdal, Lars U., Chargari, Cyrus, Lindegaard, Jacob C., Schmid, Maximilian P., Sturdza, Alina, Jürgenliemk-Schulz, Ina M., Mahantshetty, Umesh, Hoskin, Peter, Segedin, Barbara, Rai, Bhavana, Bruheim, Kjersti, Wiebe, Ericka, Van der Steen-Banasik, Elzbieta, Cooper, Rachel, Van Limbergen, Erik, Sundset, Marit, Pieters, Bradley R., Lutgens, Ludy C.H.W., Tan, Li Tee, Villafranca, Elena, Smet, Stéphanie, Jastaniyah, Noha, Nout, Remi A., Kirisits, Christian, Chopra, Supriya, Kirchheiner, Kathrin, Tanderup, Kari, and EMBRACE Collaborative Group

Published
2022
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2. Dose-Volume Effects and Risk Factors for Late Diarrhea in Cervix Cancer Patients After Radiochemotherapy With Image Guided Adaptive Brachytherapy in the EMBRACE I Study

Author

K. Jensen, Nina B., Pötter, Richard, Spampinato, Sofia, Fokdal, Lars U., Chargari, Cyrus, Lindegaard, Jacob C., Schmid, Maximilian P., Sturdza, Alina, Jürgenliemk-Schulz, Ina M., Mahantshetty, Umesh, Segedin, Barbara, Bruheim, Kjersti, Hoskin, Peter, Rai, Bhavana, Wiebe, Ericka, Cooper, Rachel, Van der Steen-Banasik, Elzbieta, Van Limbergen, Erik, Sundset, Marit, Pieters, Bradley R., Nout, Remi A., Kirisits, Christian, Kirchheiner, Kathrin, and Tanderup, Kari

Published
2021
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3. Persistence of Late Substantial Patient-Reported Symptoms (LAPERS) After Radiochemotherapy Including Image Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer: A Report From the EMBRACE Study

Author

Vittrup, Anders S., Tanderup, Kari, Bentzen, Søren M., Jensen, Nina B.K., Spampinato, Sofia, Fokdal, Lars U., Lindegaard, Jacob C., Sturdza, Alina, Schmid, Maximilian, Segedin, Barbara, Jürgenliemk-Schulz, Ina M., Bruheim, Kjersti, Mahantshetty, Umesh, Haie-Meder, Christine, Rai, Bhavana, Cooper, Rachel, van der Steen-Banasik, Elzbieta, Sundset, Marit, Huang, Fleur, Nout, Remi A., Villafranca, Elena, Van Limbergen, Erik, Pieters, Bradley R., Tan, Li Tee, Lutgens, Ludy C.H.W., Hoskin, Peter, Pötter, Richard, and Kirchheiner, Kathrin

Published
2021
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4. Impact of Vaginal Symptoms and Hormonal Replacement Therapy on Sexual Outcomes After Definitive Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: Results from the EMBRACE-I Study

Author

Kirchheiner, Kathrin, Smet, Stéphanie, Jürgenliemk-Schulz, Ina M., Haie-Meder, Christine, Chargari, Cyrus, Lindegaard, Jacob C., Fokdal, Lars U., Spampinato, Sofia, Schmid, Maximilian P., Sturdza, Alina, Mahantshetty, Umesh, Segedin, Barbara, Bruheim, Kjersti, Rai, Bhavana, Cooper, Rachel, Van der Steen-Banasik, Elzbieta, Wiebe, Ericka, Sundset, Marit, van Limbergen, Erik, Villafranca, Elena, Westerveld, Henrike, Tan, Li Tee, Pötter, Richard, Tanderup, Kari, and Nout, Remi A.

Published
2021
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6. Impact of Vaginal Symptoms and Hormonal Replacement Therapy on Sexual Outcomes After Definitive Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: Results from the EMBRACE-I Study.

Author

Kirchheiner, Kathrin, Smet, Stéphanie, Jürgenliemk-Schulz, Ina M., Haie-Meder, Christine, Chargari, Cyrus, Lindegaard, Jacob C., Fokdal, Lars U., Spampinato, Sofia, Schmid, Maximilian P., Sturdza, Alina, Mahantshetty, Umesh, Segedin, Barbara, Bruheim, Kjersti, Rai, Bhavana, Cooper, Rachel, Van der Steen-Banasik, Elzbieta, Wiebe, Ericka, Sundset, Marit, van Limbergen, Erik, and Villafranca, Elena

Subjects
*CERVICAL cancer, *HORMONE therapy, *SEXUAL intercourse, *SECONDARY prevention, *VULVODYNIA, *UTERINE hemorrhage, *RESEARCH, *HUMAN sexuality, *RESEARCH methodology, *EVALUATION research, *COMPARATIVE studies, *QUALITY of life, *QUESTIONNAIRES, *RADIOTHERAPY, *LONGITUDINAL method, CERVIX uteri tumors
Abstract

Purpose: To evaluate patient-reported sexual outcomes after chemoradiation therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer in the observational, prospective, multicenter EMBRACE-I study.Methods and Materials: Sexual outcomes were assessed prospectively with the European Organization for Research and Treatment of Cancer Qualify of Life Questionnaire (EORTC-QLQ-CX24) at baseline and follow-up. Crude incidence and prevalence rates of sexual activity, vaginal functioning problems (dryness, shortening, tightening, pain during intercourse), and sexual enjoyment were evaluated. Associations between pain during intercourse and vaginal functioning problems or sexual enjoyment were calculated, pooling observations over all follow-ups (Spearman correlation coefficient). In patients who were frequently sexually active (≥50% of follow-ups), the effects of regular hormonal replacement therapy (HRT) on vaginal functioning problems were evaluated (Pearson χ2).Results: The analysis involved 1045 patients with a median follow-up of 50 months. Sexual activity was reported by 22% of patients at baseline and by 40% to 47% of patients during follow-up (prevalence rates). Vaginal functioning problems in follow-up were dryness (18%-21%), shortening (15%-22%), tightening (16%-22%), pain during intercourse (9%-21%), and compromised enjoyment (37%-47%). Pain during intercourse was significantly associated with vaginal tightening (r = 0.544), shortening (r = 0.532), and dryness (r = 0.408) and negatively correlated with sexual enjoyment (r = -0.407). Regular HRT was associated with significantly less vaginal dryness (P = .015), shortening (P = .024), pain during intercourse (P = .003), and borderline higher sexual enjoyment (P = .062).Conclusions: Vaginal functioning problems are associated with pain and compromised sexual enjoyment. Further effort is required for the primary prevention of vaginal morbidity with dose optimization and adaptation. Secondary prevention strategies, including HRT for vaginal and sexual health after radiation therapy in locally advanced cervical cancer, should be considered and sexual rehabilitation programs should be developed further. [ABSTRACT FROM AUTHOR]

Published
2022
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