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Start Over Author "A. d'Souza" Journal international journal of radiation oncology*biology*physics
716 results on '"A. d'Souza"'

2. Neighborhood Deprivation and Rurality Associated With Patient-Reported Outcomes and Survival in Men With Prostate Cancer in NRG Oncology RTOG 0415

Author

Bai, Jinbing, Pugh, Stephanie L., Eldridge, Ronald, Yeager, Katherine A., Zhang, Qi, Lee, W. Robert, Shah, Amit B., Dayes, Ian S., D'Souza, David P., Michalski, Jeff M., Efstathiou, Jason A., Longo, John M., Pisansky, Thomas M., Maier, Jordan M., Faria, Sergio L., Desai, Anand B., Seaward, Samantha A., Sandler, Howard M., Cooley, Mary E., and Bruner, Deborah W.

Published
2023
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3. GEC-ESTRO (ACROP)–ABS–CBG Consensus Brachytherapy Target Definition Guidelines for Recurrent Endometrial and Cervical Tumors in the Vagina

Author

Kamrava, Mitchell, Leung, Eric, Bachand, Francois, Beriwal, Sushil, Chargari, Cyrus, D'Souza, David, Erickson, Beth, Fokdal, Lars, Han, Kathy, Harkenrider, Matthew, Lin, Lilie, Mahantshetty, Umesh, Nesvacil, Nicole, Ravi, Ananth, Schmid, Max, Vigneault, Eric, Westerveld, Henrike, Yashar, Catheryn, and Nout, Remi

Published
2023
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4. Prostate-Specific Antigen After Neoadjuvant Androgen Suppression in Prostate Cancer Patients Receiving Short-Term Androgen Suppression and External Beam Radiation Therapy: Pooled Analysis of Four NRG Oncology Radiation Therapy Oncology Group Randomized Clinical Trials

Author

Hallemeier, Christopher L, Zhang, Peixin, Pisansky, Thomas M, Hanks, Gerald E, McGowan, David G, Roach, Mack, Zeitzer, Kenneth L, Firat, Selim Y, Husain, Siraj M, D'Souza, David P, Souhami, Luis, Parliament, Matthew B, Rosenthal, Seth A, Lukka, Himanshu R, Rotman, Marvin, Horwitz, Eric M, Miles, Edward F, Paulus, Rebecca, and Sandler, Howard M

Subjects
Urologic Diseases, Prostate Cancer, Clinical Research, Aging, Cancer, Good Health and Well Being, Aged, Androgen Antagonists, Cause of Death, Humans, Kallikreins, Male, Multivariate Analysis, Neoadjuvant Therapy, Neoplasm Grading, Neoplasm Staging, Prostate-Specific Antigen, Prostatic Neoplasms, Radiotherapy Dosage, Treatment Failure, Other Physical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeTo validate whether prostate-specific antigen (PSA) level after neoadjuvant androgen suppression (neoAS) is associated with long-term outcome after neoAS and external beam radiation therapy (RT) with concurrent short-term androgen suppression (AS) in patients with prostate cancer.Methods and materialsThis study included 2404 patients. The patients were treated with neoAS before RT and concurrent AS (without post-RT AS) and were pooled from NRG Oncology/RTOG trials 9202, 9408, 9413, and 9910. Multivariable models were used to test associations between the prespecified dichotomized post-neoAS, pre-RT PSA level (≤0.1 vs >0.1 ng/mL) groupings, and clinical outcomes.ResultsThe median follow-up for surviving patients was 9.4 years. The median post-neoAS, pre-RT PSA level was 0.3 ng/mL, with 32% of patients having levels ≤0.1 ng/mL. Race, Gleason score, tumor stage, node stage, pretreatment PSA level, and duration of neoAS were associated with the groups of patients with PSA levels ≤0.1 and >0.1 ng/mL. In univariate analyses, post-neoAS, pre-RT PSA level >0.1 ng/mL was associated with increased risks of biochemical failure (hazard ratio [HR], 2.04; P 0.1 ng/mL was independently associated with increased risk of biochemical failure (HR, 2.00; P 0.1 ng/mL after neoAS and before the start of RT had less favorable clinical outcomes than patients whose PSA level was ≤0.1 ng/mL. The role of post-neoAS, pre-RT PSA level relative to PSA levels obtained along the continuum of medical care is not presently defined but could be tested in future clinical trials.

Published
2019

8. Phase 2 Study of a Temozolomide-Based Chemoradiation Therapy Regimen for High-Risk, Low-Grade Gliomas: Long-Term Results of Radiation Therapy Oncology Group 0424

Author

Fisher, Barbara J., Pugh, Stephanie L., Macdonald, David R., Chakravatri, Arnab, Lesser, Glenn J., Fox, Sherry, Rogers, C. Leland, Werner-Wasik, Maria, Doyle, Thomas, Bahary, Jean-Paul, Fiveash, John B., Bovi, Joseph A., Howard, Steven P., Michael Yu, Hsiang-Hsuan, D’Souza, David, Laack, Nadia N., Barani, Igor J., Kwok, Young, Wahl, Daniel R., Strasser, Jon F., Won, Minhee, and Mehta, Minesh P.

Published
2020
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10. Is ultra-hypofractionated whole pelvis radiotherapy (WPRT) as well tolerated as conventionally fractionated WPRT in prostate cancer patients? Early results from the HOPE Trial.

Author

Mendez, Lucas C., primary, Crook, Juanita, additional, Martell, Kevin, additional, Schaly, Bryan, additional, Hoover, Douglas A., additional, Dhar, Aneesh, additional, Velker, Vikram, additional, Ahmad, Belal, additional, Lock, Michael, additional, Halperin, Ross, additional, Warner, Andrew, additional, Bauman, Glenn S., additional, and D'Souza, David P., additional

Published
2023
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15. Long-Term Follow-Up Analysis of NRG Oncology RTOG 0415: A Randomized Phase III Non-Inferiority Study Comparing Two Fractionation Schedules in Patients with Favorable-Risk Prostate Cancer

Author

Lee, W.R., primary, Dignam, J.J., additional, Amin, M., additional, Bruner, D.W., additional, Low, D., additional, Swanson, G.P., additional, Shah, A.B., additional, D'Souza, D.P., additional, Michalski, J.M., additional, Dayes, I., additional, Seaward, S.A., additional, Hall, W.A., additional, Nguyen, P.L., additional, Pisansky, T.M., additional, Faria, S.L., additional, Chen, Y., additional, Rodgers, J., additional, and Sandler, H.M., additional

Published
2023
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16. Neighborhood Deprivation and Rurality Associated With Patient-Reported Outcomes and Survival in Men With Prostate Cancer in NRG Oncology RTOG 0415

Author

Jinbing Bai, Stephanie L. Pugh, Ronald Eldridge, Katherine A. Yeager, Qi Zhang, W. Robert Lee, Amit B. Shah, Ian S. Dayes, David P. D'Souza, Jeff M. Michalski, Jason A. Efstathiou, John M. Longo, Thomas M. Pisansky, Jordan M. Maier, Sergio L. Faria, Anand B. Desai, Samantha A. Seaward, Howard M. Sandler, Mary E. Cooley, and Deborah W. Bruner

Subjects
Cancer Research, Radiation, Oncology, Radiology, Nuclear Medicine and imaging
Published
2023
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20. Is Remote Learning as Effective as In-Person Learning for Contouring Education? A Prospective Comparison of Face-to-Face versus Online Delivery of the Anatomy and Radiology Contouring Bootcamp

Author

Vikram Velker, Andrew Warner, Katherine E. Willmore, Paige Eansor, Anthony C. Nichols, Nicole Campbell, Keng Yeow Tay, Glenn Bauman, Eric Leung, Zahra Kassam, Leah A. D'Souza, Manas Sharma, Madeleine E. Norris, and David A. Palma

Subjects
Cancer Research, Contouring, medicine.medical_specialty, Radiation, Coronavirus disease 2019 (COVID-19), business.industry, MEDLINE, Remote learning, Anatomy, Knowledge acquisition, Education, Distance, Medical physicist, Face-to-face, Oncology, Radiation oncology, Radiation Oncology, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Radiology, business
Abstract

The Anatomy and Radiology Contouring (ARC) Bootcamp was a face-to-face (F2F) intervention providing integrated education for radiation oncology (RO) residents and medical physicists. To increase access, we launched an online offering in 2019. We evaluated the effect of the online course on participants' knowledge acquisition, contouring skills, and self-confidence by comparing it with the F2F course.Using modules, the online course offers content similar to that of the F2F comparator. Participants from the 2019 F2F and the 2019-2020 online course completed pre- and postevaluations assessing anatomy and radiology knowledge, contouring skills, self-confidence, and course satisfaction.There were 180 individuals enrolled (F2F: n = 40; online: n = 140); 57 participants (F2F: n = 30; online: n = 27) completed both evaluations. The online course had a wider geographic participation (19 countries) than F2F (4 countries). F2F had primarily RO resident participation (80%), compared with online (41%). Both cohorts demonstrated similar improvements in self-confidence pertaining to anatomy and radiology knowledge, contouring skills, and interpreting radiology images (all P.001). Both the online (mean ± SD improvement: 6.6 ± 6.7 on a 40-point scale; P.001) and F2F (3.7 ± 5.7; P = .002) groups showed anatomy and radiology knowledge improvement. Only the F2F group demonstrated improvement with the contouring assessment (F2F: 0.10 ± 0.17 on a 1-point Dice scale; P = .004; online: 0.07 ± 0.16; P = .076). Both cohorts perceived the course as a positive experience (F2F: 4.8 ± 0.4 on a 5-point scale; online: 4.5 ± 0.6), stated it would improve their professional practice (F2F: 4.6 ± 0.5; online: 4.2 ± 0.8), and said they would recommend it to others (F2F: 4.8 ± 0.4; online: 4.4 ± 0.6).The online ARC Bootcamp demonstrated improved self-confidence, knowledge scores, and high satisfaction levels among participants. The offering had lower completion rates but was more accessible to geographic regions, provided a flexible learning experience, and allowed for ongoing education during the COVID-19 pandemic.

Published
2022
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21. Neighborhood Deprivation and Rurality Associated With Patient-Reported Outcomes and Survival in Men With Prostate Cancer in NRG RTOG 0415

Author

Bai, Jinbing, primary, Pugh, Stephanie L., additional, Eldridge, Ronald, additional, Yeager, Katherine A., additional, Zhang, Qi, additional, Lee, W. Robert, additional, Shah, Amit B., additional, Dayes, Ian S., additional, D'Souza, David P., additional, Michalski, Jeff M., additional, Efstathiou, Jason A., additional, Longo, John M., additional, Pisansky, Thomas M., additional, Maier, Jordan M., additional, Faria, Sergio L., additional, Desai, Anand B., additional, Seaward, Samantha A., additional, Sandler, Howard M., additional, Cooley, Mary E., additional, and Bruner, Deborah W., additional

Published
2023
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23. Dosimetric Predictors of Acute and Late Gastrointestinal Toxicities in Stereotactic Online Adaptive Magnetic Resonance-Guided Radiotherapy (SMART) for Locally Advanced Pancreatic Adenocarcinoma

Author

D'Souza, A., primary, Stowe, H.B., additional, Green, O.L., additional, Hugo, G.D., additional, Ginn, J., additional, Maraghechi, B., additional, Kang, K.H., additional, Huang, Y., additional, Kim, H., additional, Badiyan, S.N., additional, Samson, P., additional, Robinson, C.G., additional, Price, A., additional, and Henke, L.E., additional

Published
2022
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24. RTOG/NRG 1115 Quality of Life of Phase III Dose Escalated Radiation Therapy (RT) and Standard Androgen Deprivation Therapy (ADT) with GnRH Agonist vs. Dose Escalated RT and ADT with GnRH Agonist and Orteronel (TAK-700) for Men with High-Risk Prostate

Author

Bruner, D.W., primary, Pugh, S., additional, Michaelson, D., additional, Hamstra, D.A., additional, Bachand, F., additional, Master, V., additional, Torres, M., additional, Kaplan, I.D., additional, Rosenthal, S.A., additional, Roach, M., additional, Raben, A., additional, Michalski, J.M., additional, Kavadi, V.S., additional, Ferguson, M., additional, Morgan, S.C., additional, D'Souza, D.P., additional, DeMora, L., additional, Sandler, H.M., additional, and Movsas, B., additional

Published
2022
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26. Comparison and Consensus Guidelines for Delineation of Clinical Target Volume for CT- and MR-Based Brachytherapy in Locally Advanced Cervical Cancer

Author

Viswanathan, Akila N., Erickson, Beth, Gaffney, David K., Beriwal, Sushil, Bhatia, Sudershan K., Lee Burnett, Omer, III, D'Souza, David P., Patil, Nikhilesh, Haddock, Michael G., Jhingran, Anuja, Jones, Ellen L., Kunos, Charles A., Lee, Larissa J., Lin, Lilie L., Mayr, Nina A., Petersen, Ivy, Petric, Primoz, Portelance, Lorraine, Small, William, Jr., Strauss, Jonathan B., Townamchai, Kanokpis, Wolfson, Aaron H., Yashar, Catheryn M., and Bosch, Walter

Published
2014
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36. Dosimetric Predictors of Acute and Late Gastrointestinal Toxicities in Stereotactic Online Adaptive Magnetic Resonance-Guided Radiotherapy (SMART) for Locally Advanced Pancreatic Adenocarcinoma

Author

A. D'Souza, H.B. Stowe, O.L. Green, G.D. Hugo, J. Ginn, B. Maraghechi, K.H. Kang, Y. Huang, H. Kim, S.N. Badiyan, P. Samson, C.G. Robinson, A. Price, and L.E. Henke

Subjects
Cancer Research, Radiation, Oncology, Radiology, Nuclear Medicine and imaging
Published
2022
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41. Phase 2 Study of a Temozolomide-Based Chemoradiation Therapy Regimen for High-Risk, Low-Grade Gliomas: Long-Term Results of Radiation Therapy Oncology Group 0424

Author

Jean Paul Bahary, John B. Fiveash, Glenn J. Lesser, Daniel R. Wahl, Young Kwok, Maria Werner-Wasik, C. Leland Rogers, Jon Strasser, Minesh P. Mehta, Minhee Won, Thomas J. Doyle, Steven P. Howard, David D'Souza, David R. Macdonald, Sherry Fox, Igor J. Barani, Stephanie L. Pugh, Hsiang Hsuan Michael Yu, Joseph Bovi, Barbara Fisher, Nadia N. Laack, and Arnab Chakravatri

Subjects
Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Population, Kaplan-Meier Estimate, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Glioma, Temozolomide, medicine, Clinical endpoint, Humans, Radiology, Nuclear Medicine and imaging, Progression-free survival, education, education.field_of_study, Radiation, Brain Neoplasms, business.industry, Chemoradiotherapy, medicine.disease, Progression-Free Survival, Radiation therapy, Regimen, 030220 oncology & carcinogenesis, Female, Neoplasm Grading, business, medicine.drug
Abstract

PURPOSE: To report the long-term outcomes of the RTOG 0424 study of a high-risk, low-grade glioma population treated with concurrent and adjuvant temozolomide (TMZ) and radiation therapy (RT). METHODS AND MATERIALS: For this single-arm, phase 2 study, patients with low-grade gliomas with ≥3 risk factors (age ≥40 years, astrocytoma, bihemispheric tumor, size ≥6 cm, or preoperative neurologic function status >1) received RT (54 Gy in 30 fractions) with TMZ and up to 12 cycles of post-RT TMZ. The initial primary endpoint P was overall survival (OS) at 3 years after registration. Secondary endpoints included progression-free survival (PFS) and the association of survival outcomes with methylation status. The initial 3-year report of this study was published in 2015. RESULTS: The study accrued 136 patients, of whom 129 were analyzable. The median follow-up for surviving patients was 9.0 years. The 3-year OS was 73.5% (95% confidence interval, 65.8%−81.1%), numerically superior to the 3-year OS historical control of 54% (P < .001). The median survival time was 8.2 years (95% confidence interval, 5.6–9.1). Five- and 10-year OS rates were 60.9% and 34.6%, respectively, and 5- and 10-year PFS rates were 46.8% and 25.5%, respectively. CONCLUSIONS: The long-term results confirmed the findings from the initial report for efficacy, suggesting OS and PFS outcomes with the RT-TMZ regimen exceeded historical control groups treated with radiation alone. Toxicity was acceptable.

Published
2020
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43. Association of Short-Term Patient-Reported Outcomes With Long-Term Oncologic Outcomes in Localized Prostate Cancer Patients Treated With Radiation Therapy and Androgen Deprivation Therapy in a Randomized Controlled Trial

Author

Robert MacRae, Christopher Gualano, Shawn Malone, Daniel E. Spratt, Scott C. Morgan, Fletcher Drogos, Scott Grimes, Michael Zhou, Dibya Mukherjee, Leah A. D'Souza, Soumyajit Roy, and Julia Malone

Subjects
Male, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Context (language use), law.invention, Prostate cancer, Randomized controlled trial, law, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Patient Reported Outcome Measures, Stage (cooking), Radiation, Performance status, Urinary symptoms, business.industry, Prostatic Neoplasms, Androgen Antagonists, Prostate-Specific Antigen, medicine.disease, Radiation therapy, Oncology, Androgens, Quality of Life, Patient-reported outcome, business
Abstract

Both oncologic outcomes and patient-reported outcomes are pivotal in prostate cancer (PCa). However, it remains unknown if there is any association between these 2 outcomes. In this secondary analysis of a randomized controlled trial, we investigated the association of short-term changes in patient-reported outcome with long-term event-free survival (EFS) and metastasis-free survival (MFS) in localized PCa.Localized PCa patients with a Gleason score ≤7, clinical stage T1b to T3a, and prostate-specific antigen (PSA)30 ng/mL were randomized to neoadjuvant and concurrent androgen deprivation therapy (ADT) for 6 months starting 4 months before prostate radiation therapy or concurrent and adjuvant ADT for 6 months starting simultaneously with radiation therapy. Patient-reported symptom burden was evaluated using the European Organisation for Research and Treatment of Cancer quality of life questionnaire (QLQ)-PR.25. Clinically meaningful deterioration (CMD) was defined as a ≥10-point worsening at any time within 10 months postrandomization regardless of subsequent improvement. Landmark analyses were performed to determine the association of CMD of urinary and bowel symptoms separately with EFS and MFS in patients who responded to the baseline questionnaire, were alive, and were event free at 10 months.Overall, 393 patients had responded to the baseline QLQ. One patient died, and 1 patient had failure within 10 months. Therefore, 391 patients were eligible for the landmark analyses. After adjusting for age, Gleason score, PSA, performance status, and treatment group, CMD of urinary symptoms was associated with worse EFS (hazard ratio [HR], 1.79; 95% confidence interval [CI], 1.21-2.65) and MFS (HR, 1.69; 95% CI, 1.11-2.57). Considering deaths as competing events, CMD of urinary symptoms was associated with a significant increase in the relative incidence of progression (subdistribution HR, 2.42; 95% CI, 1.12-5.20). However, no association was found between CMD of bowel symptoms and EFS or MFS.In this study, short-term CMD of urinary symptoms was associated with significantly inferior EFS and MFS and an increase in the relative incidence of progression. Further investigations are needed to explore the biological rationale of such association in the context of ADT and radiation therapy.

Published
2021

44. RTOG/NRG 1115 Quality of Life of Phase III Dose Escalated Radiation Therapy (RT) and Standard Androgen Deprivation Therapy (ADT) with GnRH Agonist vs. Dose Escalated RT and ADT with GnRH Agonist and Orteronel (TAK-700) for Men with High-Risk Prostate

Author

D.W. Bruner, S. Pugh, D. Michaelson, D.A. Hamstra, F. Bachand, V. Master, M. Torres, I.D. Kaplan, S.A. Rosenthal, M. Roach, A. Raben, J.M. Michalski, V.S. Kavadi, M. Ferguson, S.C. Morgan, D.P. D'Souza, L. DeMora, H.M. Sandler, and B. Movsas

Subjects
Cancer Research, Radiation, Oncology, Radiology, Nuclear Medicine and imaging
Published
2022
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47. Chemoradiation With or Without Metformin in Locally Advanced Cervical Cancer: Phase II Randomized Trial

Author

Han, K., primary, Fyles, T.W., additional, Shek, T., additional, Croke, J.M., additional, Dhani, N., additional, D'Souza, D.P., additional, Lee, T.Y., additional, Chaudary, N., additional, Cairns, R., additional, Pintilie, M., additional, Vines, D., additional, Jaffray, D.A., additional, Metser, U., additional, Milosevic, M., additional, and Koritzinsky, M., additional

Published
2021
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48. Stereotactic Pelvic Adjuvant Radiation Therapy in Cancers of the Uterus (SPARTACUS): A Multicenter Prospective Trial Evaluating Acute Toxicities and Patient Reported Outcomes

Author

Leung, E.W., primary, Gladwish, A.P., additional, Davidson, M.T.M., additional, Taggar, A., additional, Barnes, E., additional, Donovan, E., additional, Gien, L.T., additional, Covens, A., additional, Vicus, D., additional, Kupets, R., additional, Han, K., additional, Velker, V., additional, Mendez, L., additional, MacKay, H., additional, Cheung, P., additional, Loblaw, D.A., additional, and D'Souza, D.P., additional

Published
2021
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49. Is Remote Learning as Effective as In-Person Learning for Contouring Education? A Comparison of Face-to-Face vs. Online Delivery of the Anatomy and Radiology Contouring Bootcamp

Author

Eansor, P., primary, D'Souza, L.A., additional, Norris, M., additional, Willmore, K., additional, Kassam, Z., additional, Leung, E.W., additional, Nichols, A., additional, Sharma, M., additional, Tay, K.Y., additional, Velker, V., additional, Bauman, G.S., additional, Warner, A., additional, Campbell, N., additional, and Palma, D.A., additional

Published
2021
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