1. Role of ethanolic extract ofMorus albaleaves on some biochemical and hematological alterations in irradiated male rats
- Author
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Saleh E. Ashour and Naglaa E. Mohamed
- Subjects
Male ,0301 basic medicine ,medicine.medical_treatment ,Whole body irradiation ,L-Lactate dehydrogenase ,Pharmacology ,Antioxidants ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Male rats ,medicine ,Animals ,Radiology, Nuclear Medicine and imaging ,Irradiation ,Creatine Kinase ,L-Lactate Dehydrogenase ,Radiological and Ultrasound Technology ,biology ,Plant Extracts ,Chemistry ,Insulin ,Glutathione ,Moraceae ,biology.organism_classification ,Lipids ,Rats ,Plant Leaves ,030104 developmental biology ,Gamma Rays ,030220 oncology & carcinogenesis ,biology.protein ,Creatine kinase ,Morus ,Whole-Body Irradiation - Abstract
The present study aimed to evaluate the protective role of "Morus alba Linn (Family: Moraceae) commonly known as mulberry" leaves extract against hazardous effects of gamma rays in male rats.Thirty six male albino rats were divided into six groups (six rats/group); (1) control group received 1 ml distilled water, (2) low dose of extract (100 mg/kg) group treated daily with low oral dose of ethanolic extract of mulberry leaves (100 mg/kg body weight (b.wt.)) for 21 consecutive days, (3) high dose of extract (200 mg/kg) group treated daily with high oral dose of ethanolic extract of mulberry leaves (200 mg/kg b.wt.) for the same period, (4) irradiated group rats were subjected to whole body gamma irradiation at a shot dose of 7 Gy, (5) low dose of extract + irradiated group treated daily with low oral dose of ethanolic extract of mulberry leaves (100 mg/kg b.wt.) for 21 consecutive days then rats were exposed to gamma irradiation at a single dose of 7 Gy, (6) high dose of extract + irradiation group treated daily with high oral dose of ethanolic extract of mulberry leaves (200 mg/kg b.wt.) for 21 consecutive days then rats were exposed to gamma irradiation at a single dose of 7 Gy. Rats were sacrificed 1, 7, 15 days post gamma irradiation in all groups. Blood samples were taken at three intervals time in the six groups.The results showed that whole body irradiation of rats induced significant decrease (p 0.05) in red blood cells (RBCs), hemoglobin (Hb), hematocrit percentage (HCT%), platelet, white blood cells (WBCs), lymphocytes, neutrophils, serum glucose-6-phosphate dehydrogenase (G-6-PD) and insulin. The data also showed significant increase (p 0.05) in serum total lipids, phospholipids, cholesterol, triglycerides, lactate dehydrogenase (LDH), creatine kinase (CK), and plasma glucose. Administration of mulberry leaves extract, either low or high concentrations to rats prior to irradiation caused significant improvement in the studied parameters.Mulberry leaves extract prior to exposure to gamma irradiation has radio protector against hazardous effect of irradiation in male rats.
- Published
- 2018
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