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The need to synthesize qualitative research in order to inform fields of study has been highlighted as a critical imperative in recent years. Since that time, there have been a number of attempts to identify methodological approaches to achieving such a goal. Despite some notable efforts in this regard, the metasynthesis research approach continues to be somewhat elusive with regard to its steps and procedures. The authors of this article describe their experience conducting a metasynthesis of qualitative research regarding transformation in chronic illness and disability. The particular emphasis of the article will be the practical strategies and procedures that assisted them in conducting the project in a rigorous and meaningful way. The authors emphasize the need for continued dialogue about strategies and procedures in metasynthesis that will aid researchers who are contemplating this complex research approach.