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Summary: Objective:: The study aims to determine the prevalence of eczema among Lebanese adolescents and identify demographic, nutritional and environmental characteristics associated with eczema. Methods:: A cross-sectional study conducted on a convenient sample of 3153 students (13-14 years) selected from five different provinces in Lebanon. Significant unadjusted demographic, nutritional and environmental variables were considered in a stepwise regression model. Results:: Ever having an itchy rash that lasted for a period more than six months was reported by 788 (25.0%) adolescents, while 404 (12.8%) reported ever having eczema. Females and passive smokers were at 1.5 increased risk of having eczema than their counterparts. Exercising regularly, living near a busy area, and frequent eating of eggs were positively associated with eczema. Finally, adolescents who suffered from allergic diseases, asthma (Odds ratio (OR): 1.64, 95% CI: 1.16–2.32), rhinitis (OR: 1.35, 95% CI: 1.07–1.70) and hay fever (OR: 2.77; 95% CI: 2.12–3.62) also reported having had eczema. Conclusion:: Environmental factors were found to play an important role in the prevalence of eczema among adolescents.