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In permafrost regions, the soil settlement disaster owing to permafrost degradation has become one of the important reasons for buried warm-oil pipelines failure. In this paper, the 3D sequential thermo-mechanical coupled model is carried out to investigate the interaction between buried warm-oil pipeline and surrounding permafrost. The effects of parameters, including thaw-settlement coefficient, length of transition zone, diameter-thickness ratio and internal pressure, on the pipeline mechanical behavior are numerically investigated. Among them, the thaw-settlement coefficient and length of transition zone present more significant effects on the peak strain of the pipeline. In addition, the effects of insulation layer and two-phase closed thermosyphon (TPCT) on pipeline–soil interaction are investigated in thermal and mechanical fields. With no protective measure, the permafrost layer under pipeline will completely degrade in about 20 years with 0.33m/a. The pipeline is considered to reach failure limitation even within 10 years. However, under the influence of combined measure, the permafrost degradation rate is only about 1/10 of that without protective measure. The peak compressive strain is significantly lower than the critical compressive strain, and the pipeline remains safe for 50 years. Therefore, the combined measure is an ideal method for ensuring pipeline safety in permafrost regions. • Permafrost layer is well protected by the combined measure. • The TSC and the LTZ show significant effects on the peak strain of pipeline. • Pipeline remains safe for 50 years under the influence of combined measure. [ABSTRACT FROM AUTHOR]