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Your search keyword '"González Barcia, Miguel"' showing total 8 results
Start Over Author "González Barcia, Miguel" Journal international journal of pharmaceutics
8 results on '"González Barcia, Miguel"'

1. Design and biopharmaceutical preclinical characterisation of a new thermosensitive hydrogel for the removal of gastric polyps

Author

Varela-Rey, Iria, de la Iglesia, Daniel, San Bruno-Ruz, Alba, Mejuto-Fernández, Rafael, Monteserín-Ron, Luzdivina, López-Diaz, Javier, García-Salom, Pedro, González-Cantalapiedra, Antonio, Manuel Brea, Jose, Piña-Márquez, Rocío, Díaz-Tomé, Victoria, González-Barcia, Miguel, Zarra-Ferro, Irene, Mondelo-García, Cristina, Dominguez-Muñoz, J Enrique, Otero-Espinar, Francisco J, and Fernández-Ferreiro, Anxo more...

Published
2023
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2. PET study of intravitreal adalimumab pharmacokinetics in a uveitis rat model

Author

García-Otero, Xurxo, primary, Mondelo-García, Cristina, additional, Bandín-Vilar, Enrique, additional, Gómez-Lado, Noemí, additional, Silva-Rodríguez, Jesús, additional, Rey-Bretal, David, additional, Victoria Otero-Espinar, M., additional, Adan, Alfredo, additional, González-Barcia, Miguel, additional, Aguiar, Pablo, additional, Otero-Espinar, Francisco J., additional, and Fernández-Ferreiro, Anxo, additional more...

Published
2022
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5. In situ forming and mucoadhesive ophthalmic voriconazole/HPβCD hydrogels for the treatment of fungal keratitis

Author

Díaz-Tomé, Victoria, primary, García-Otero, Xurxo, additional, Varela-Fernández, Rubén, additional, Martín-Pastor, Manuel, additional, Conde-Penedo, Andrea, additional, Aguiar, Pablo, additional, González-Barcia, Miguel, additional, Fernández-Ferreiro, Anxo, additional, and Otero-Espinar, Francisco J, additional more...

Published
2021
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7. Cysteamine polysaccharide hydrogels: Study of extended ocular delivery and biopermanence time by PET imaging

Author

Luaces-Rodríguez, Andrea, primary, Díaz-Tomé, Victoria, additional, González-Barcia, Miguel, additional, Silva-Rodríguez, Jesús, additional, Herranz, Michel, additional, Gil-Martínez, María, additional, Rodríguez-Ares, María Teresa, additional, García-Mazás, Carla, additional, Blanco-Mendez, José, additional, Lamas, María Jesús, additional, Otero-Espinar, Francisco Javier, additional, and Fernández-Ferreiro, Anxo, additional more...

Published
2017
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8. Preclinical characterization of endotoxin-induced uveitis models using OCT, PET/CT and proteomics.

Author

Cuartero-Martínez, Andrea, García-Otero, Xurxo, Codesido, Jessica, Gómez-Lado, Noemí, Mateos, Jesús, Bravo, Susana B., Rodríguez-Fernández, Carmen Antía, González-Barcia, Miguel, Aguiar, Pablo, Ortega-Hortas, Marcos, Otero-Espinar, Francisco J., and Fernández-Ferreiro, Anxo more...

Subjects
*POSITRON emission tomography computed tomography, *EYE inflammation, *OPTICAL coherence tomography, *COMPUTED tomography, *INTRAOCULAR pressure
Abstract

[Display omitted] Uveitis is a group of inflammatory ocular pathologies. Endotoxin-Induced Uveitis (EIU) model represent a well-known model induced by administration of Lipopolysaccharide (LPS). The aim is to characterize two models of EIU through two routes of administration with novel noninvasive imaging techniques. 29 rats underwent Intraocular Pressure (IOP) measurements, Optical Coherence Tomography (OCT), proteomic analysis, and Positron Emission Tomography and Computed Tomography (PET/CT). Groups included healthy controls (C), BSS administered controls (Ci), systemically induced EIU with LPS (LPSs), and intravitreally induced EIU with LPS (LPSi) for IOP, OCT, and proteomic studies. For 18F-FDG PET/CT study, animals were divided into FDG-C, FDG-LPSs and FDG-LPSi groups and scanned using a preclinical PET/CT system. LPSi animals exhibited higher IOP post-induction compared to C and LPSs groups. LPSi showed increased cellular infiltrate, fibrotic membranes, and iris inflammation. Proinflammatory proteins were more expressed in EIU models, especially LPSi. PET/CT indicated higher eye uptake in induced models compared to FDG-C. FDG-LPSi showed higher eye uptake than FDG-LPSs but systemic uptake was higher in FDG-LPSs due to generalized inflammation. OCT is valuable for anterior segment assessment in experimental models. 18F-FDG PET/CT shows promise as a noninvasive biomarker for ocular inflammatory diseases. Intravitreal induction leads to higher ocular inflammation. These findings offer insights for future inflammatory disease research and drug studies. [ABSTRACT FROM AUTHOR] more...

Published
2024
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