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he present study deals with UV spectrophotometric method development & validation for simultaneous estimation of Hydrochlorothiazide and Propranolol in dosage form by Simultaneous Equation Method. The wavelengths selected for the method were at the λmax 271nm and 289nm for Hydrochlorothiazide and Propranolol respectively. The linearity of Hydrochlorothiazide and Propranolol was found to be in the range of 4-24 μg/ml & 8-48μg/ml respectively. The linear correlation was obtained (r²> 0.998) in the range of 4-24μg/ml for Hydrochlorothiazide at 271nm. The method was found to be linear (r²> 0.998) in the range of 8-48 μg/ml for Propranolol at 289 nm. The limit of detection was 0.052 μg/ml and 0.461 μg/ml for Hydrochlorothiazide and Propranolol respectively. The limit of quantification was 0.158 μg/ml and 1.397 μg/ml for Hydrochlorothiazide and Propranolol. The accuracy of the method was found to be 97-98%.The simple and economical method was successfully applied for simultaneous determination of Propranolol and Hydrochlorothizide in combined dosage form. The proposed method was validated as per ICH guidelines. [ABSTRACT FROM AUTHOR]