Search

Your search keyword '"Qin, Ning"' showing total 2 results
Start Over Author "Qin, Ning" Search Limiters Peer Reviewed Topic apoptosis Journal international journal of pediatric endocrinology
2 results on '"Qin, Ning"'

1. Chronic treatment with valproate protects INS1 cell from palmitate-induced ER stress and apoptosis by inhibiting GSK3β

Author

Shan Huang, Y Liang, Wei Wu, Xiaoping Luo, and Qin Ning

Subjects
chemistry.chemical_classification, business.industry, Endoplasmic reticulum, medicine.medical_treatment, Cell, Fatty acid, Type 2 diabetes, Pharmacology, Bioinformatics, medicine.disease, Pathogenesis, medicine.anatomical_structure, Anticonvulsant, chemistry, Apoptosis, medicine, Unfolded protein response, Oral Presentation, business
Abstract

Objective Reduction of b-cell mass is increasingly recognized as one of the main contributing factors to the pathogenesis of type 2 diabetes. Chronic free fatty acid (FFA) exposure has been shown to induce endoplasmic reticulum (ER) stress that may contribute to promoting pancreatic b-cell apoptosis. In the present study, we first investigated whether anticonvulsant sodium valproate (VPA), at clinically relevant doses, protects pancreatic b-cell from palmitate-induced apoptosis and the mechanism underlying anti-apoptosis.

Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results