1. The effect of duodenumpreserving resection of the head of the pancreas on basal and stimulated insulin, glucagon, pancreatic polypeptide, and cholecystokinin levels in dogs
- Author
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Cornelis B.H.W. Lamers, Marijke Frölich, Jan B.M.J. Jansen, Hein G. Gooszen, O. R. Guicherit, and Michael P. M. van der Burg
- Subjects
medicine.medical_specialty ,Pancreatic disease ,business.industry ,Insulin ,medicine.medical_treatment ,digestive, oral, and skin physiology ,Gastroenterology ,medicine.disease ,Glucagon ,Endocrinology ,medicine.anatomical_structure ,Oncology ,Basal (medicine) ,Internal medicine ,medicine ,Pancreatic polypeptide ,Pancreas ,business ,Pancreatic hormone ,Cholecystokinin - Abstract
Several major pancreatic resections have been proven effective for the relief of pain caused by chronic pancreatitis. Distinct morbidity, however, and interference with gastrointestinal hormone response patterns have been documented. We have tested the effect of the duodenumpreserving resection of the head of the pancreas on basal and meal-stimulated (TMA) blood glucose and plasma insulin, glucagon, pancreatic polypeptide (PP), and cholecystokinin levels (CCK) in dogs(n =9). Intravenous glucose tolerance tests (IVGTT) were performed in addition. Tests were performed before and at six and 12 wk after operation. Results of TMA were expressed in basal and integrated levels for glucose, insulin and glucagon. PP and CCK responses were expressed in incremental levels, results of IVGTT as K-values and integrated insulin response. Basal glucagon, insulin, and PP levels (mean ± SEM) decreased from 86 ± 23 to 44 ± 10 pg/mL, from 14 ± 3 to 8±1 μU/mL, and from 75 ±11 to 24±3 pM, respectively (p
- Published
- 1990
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