1. Memory problems and weight loss: A case report
- Author
-
Karavadra B and Gunawardena I
- Subjects
Thorax ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Limbic encephalitis ,Cancer ,medicine.disease ,Gastroenterology ,medicine.anatomical_structure ,Internal medicine ,Biopsy ,medicine ,Dementia ,Lung cancer ,Liver function tests ,business ,Lymph node - Abstract
This interesting case report illustrates a paraneoplastic syndrome presenting as dementia. A 75-year-old Malaysian lady with a 45-pack year smoking history presented with unintentional weight loss of three stone in three months with generalised aches and pains and short-term memory problems. Her inflammatory markers were raised, liver function tests were deranged, and her thyroid stimulating hormone was low. Cerebrospinal fluid examination revealed a mild increase in protein. On the Addenbrookes Cognitive Scale her score was 39/100 and she also had clinical features to suggest mild depression. A Computed Tomography of the thorax showed a 34mm mass anterior to the trachea and an enlarged right para-tracheal lymph node. Subsequent endo-bronchial ultrasound biopsy confirmed metastatic small-cell lung cancer. She had positive autoantibodies for anti-Hu and anti-Sox 1; indicating a paraneoplastic syndrome or limbic encephalitis. Paraneoplastic syndromes are rare and difficult to diagnose. In this case, the paraneoplastic manifestations mimicked a dementia illness.
- Published
- 2020
- Full Text
- View/download PDF