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Stem cells are unique cells which possess the ability to grow rapidly and have the potential to develop into specialized cell types in the body. Stem cell-based therapies in dentistry could help in new advances in treating damaged teeth, inducing bone regeneration, and even making a biological tooth a possibility. Whole tooth regeneration to replace the traditional dental implants is also in pipeline. Tissue-engineering applications using dental stem cells may promote more rapid healing of oral wounds and ulcers as well as the use of gene transfer methods to manipulate salivary proteins, and oral microbial colonization patterns are promising and possible. Stem cells of dental origin have multiple applications; nevertheless, there are certain limitations as well. The oncogenic potential of these cells is still to be determined in long-term clinical studies if we are to realize the benefits, meet the challenges, and avoid the risks. This review is an attempt to highlight the pros and cons of stem cells in dentistry.