1. Weight loss increases and fat loss decreases all-cause mortality rate: results from two independent cohort studies
- Author
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Raffaella Zannolli, Moonseong Heo, S B Heymsfield, Myles S. Faith, F. X. Pi-Sunyer, Angelo Pietrobelli, David B. Allison, and Theodore B. VanItallie
- Subjects
Adult ,Male ,Michigan ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Population ,Medicine (miscellaneous) ,Body Mass Index ,Cohort Studies ,Framingham Heart Study ,Weight loss ,Cause of Death ,Internal medicine ,Weight Loss ,medicine ,Humans ,risk factors ,Longitudinal Studies ,Obesity ,Prospective Studies ,Sex Distribution ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,Nutrition and Dietetics ,Framingham Risk Score ,business.industry ,Mortality rate ,Hazard ratio ,obese people ,Middle Aged ,medicine.disease ,mortality ,Surgery ,Adipose Tissue ,Massachusetts ,Cardiovascular Diseases ,Cardiology ,Female ,medicine.symptom ,business ,Body mass index - Abstract
OBJECTIVE: In epidemiological studies, weight loss is usually associated with increased mortality rate. Contrarily, among obese people, weight loss reduces other risk factors for disease and death. We hypothesised that this paradox could exist because weight is used as an implicit adiposity index. No study has considered the independent effects of weight loss and fat loss on mortality rate. We studied mortality rate as a function of weight loss and fat loss. DESIGN: Analysis of ‘time to death’ in two prospective population-based cohort studies, the Tecumseh Community Health Study (1890 subjects; 321 deaths within 16 y of follow-up) and the Framingham Heart Study (2731 subjects; 507 deaths within 8 y of follow-up), in which weight and fat (via skinfolds) loss were assessable. RESULTS: In both studies, regardless of the statistical approach, weight loss was associated with an increased, and fat loss with a decreased, mortality rate (P
- Published
- 1999