1. Correction: Prevention of obesity in toddlers (PROBIT): a randomised clinical trial of responsive feeding promotion from birth to 24 months
- Author
-
Flavia Grando, Nicoletta Ferrarese, Elsa Alberti, Giuliana Matticchio, Massimo Pasqualini, Sabrina Vinco, Maria Iuliano, Laura Baraldi, Graziana Frignani, Carmelo Bucolo, Francesco Raimo, Valeria Rossi, Cinzia Siciliano, Anna Maria Zuccolo, Valeria Vettori, Francesco Soffiati, Daniela Danieli, Emanuela Trevisan, Stefania Sirpresi, Mara Tommasi, Claudio Maffeis, Antonietta Chiriacò, Giustina Simonetti, Loretta Guarda, Florinda Destro, Anita Morandi, and Laura Fontana
- Subjects
Percentile ,Pediatrics ,medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,Overweight ,medicine.disease ,Obesity ,law.invention ,Clinical trial ,Randomized controlled trial ,law ,Sample size determination ,medicine ,Weaning ,medicine.symptom ,business ,Body mass index - Abstract
INTRODUCTION The aims of the PROBIT trial (clinicaltrials.gov: NCT03131284) were to prevent overweight or obesity occurring at two years of life, and improve feeding patterns during infancy. METHODS The trial compared 252 northern Italian newborns whose paediatricians offered their parents an educational programme from the child's birth to the age of two years (intervention arm) with 216 newborns whose parents did not undergo the programme (control arm). This sample size was 80% powerful to detect, with a 0.05 α error, a 40% lower prevalence of overweight/obesity and a 57% lower prevalence of obesity in the intervention arm. At each well visit, the parents of the children in the intervention arm were given oral and written information about protective behaviours, with particular emphasis on responsive feeding. Overweight and obesity at two years of age were, respectively, defined as a body mass index of more than the 85th and the 95th percentile in accordance with the WHO growth charts. The sample size had 80% power to detect a 40% lower prevalence of overweight/obesity and a 57% lower prevalence of obesity in the intervention arm. RESULTS At the age of two years, the prevalence of obesity in the intervention arm was 35% lower than among the controls, but the difference was not statistically significant (8.7% vs. 13.4%; p = 0.10) There was no difference in the prevalence of overweight/obesity between the groups (26.8% vs. 28.3%; p = 0.49). At the age of three months, a higher proportion of the infants in the intervention group were fed on demand (93% vs. 80%, p
- Published
- 2020