1. Chronic Kidney Disease Modifies The Relationship Between Body Fat Distribution and Blood Pressure: A Cross-Sectional Analysis
- Author
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Tandi E. Matsha, Cindy George, Andre Pascal Kengne, Rajiv T Erasmus, Florence E. Davidson, and Julia H. Goedecke
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Cross-sectional study ,business.industry ,030232 urology & nephrology ,Renal function ,Disease ,030204 cardiovascular system & hematology ,Anthropometry ,urologic and male genital diseases ,medicine.disease ,Gastroenterology ,female genital diseases and pregnancy complications ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Nephrology ,Internal medicine ,medicine ,business ,Dual-energy X-ray absorptiometry ,Body fat distribution ,Kidney disease - Abstract
Introduction Measures of adiposity are related to cardiovascular disease risk , but this relationship is inconsistent in disease states, such as chronic kidney disease (CKD). This study investigated the relationship between adiposity and blood pressure (BP) by CKD status. Materials and Methods South Africans of mixed-ancestry (n=1,621) were included. Estimated glomerular filtration rate (eGFR) was based on the modification of diet in renal disease (MDRD) equation, and CKD defined as eGFR 0.100 for all). Contrary, in prevalent CKD (6%, n=96), only BMI was inversely associated with PP (p=0.0349). In multivariable analysis, only BMI and WC remained independently associated with SBP, DBP and MAP in the overall sample. Notably, the association between BMI, WC and LFM with SBP and PP, differed by CKD status (interaction: p
- Published
- 2020
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