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This document is an editorial from the International Journal of Molecular Sciences that discusses the regulatory roles of inflammation and inflammasomes in liver diseases. It explains that while inflammation is a natural immune response that protects the body, chronic inflammation can lead to various diseases, including liver diseases. The article highlights the importance of the priming and triggering steps in the inflammatory response and the role of inflammasomes in activating inflammation. It also presents several studies that explore the regulatory roles of flavonoids, chemokines, reactive nitrogen species, and neutrophil infiltration in liver diseases. Additionally, the editorial discusses the impact of SARS-CoV-2 infection on patients with advanced chronic liver disease. The authors hope that this special issue provides insights into the role of inflammation in liver diseases and contributes to the development of novel therapeutics. [Extracted from the article]